Mitochondrial dynamics in the hippocampus is influenced by antidepressant treatment in a genetic rat model of depression

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Post-mortem, genetic, brain imaging, and peripheral cell studies showed that mitochondria may play an important role in the pathophysiology of depression and effects of antidepressant therapy. Here we investigated whether chronic antidepressant treatment on rats induce changes of the mitochondrial number in hippocampus. All rats were injected imipramine (a classic tricyclic antidepressant) or saline (i.p) once daily for 14 days on normal rats (10 mg/kg) and for 25 days on the Flinders Sensitive Lines (FSL) rats and their controls the Flinders Resistant Line (FRL) rats (15 mg/kg), a genetic rat model of depression. The unbiased stereoloy methods were used to estimate the mitochondria numerical density, the number of mitochondria and the mean size and volume of mitochondria in CA1 stratum radiatum (CA1SR) of hippocampus. The results showed that the mitochondria numerical density and the number of mitochondria in CA1SR displayed significantly smaller in the FSL-saline group compared to FRL-saline group and SD-saline group. But the mean volume of mitochondria showed significantly bigger in the FSL-saline group compared to FRL-saline group and SD-saline group. Following treatment, the FSL-imipramine group showed a significant increase in the mitochondria numerical density and the number of mitochondria compared to the FSL-saline group.In conclusion, the mitochondria numerical density and the number of mitochondria in CA1SR were significantly smaller in the FSL-saline group compared to FRL-saline group and SD-saline group. Impramine treatment can significantly increase the mitochondria numerical density and the number of mitochondria in FSL-imipramine group. Our results support the mitochondria plasticity hypothesis that depressive disorders may be related to impairments of mitochondria plasticity in hippocampus, and antidepressant treatment may counteract the structural impairments.
Original languageEnglish
JournalActa Neuropsychiatrica
Volume25
Issue number1
Pages (from-to)19
Number of pages1
ISSN0924-2708
Publication statusPublished - 2013

    Research areas

  • antidepressant agent sodium chloride imipramine tricyclic antidepressant agent hippocampus rat animal model college psychopharmacology mitochondrial dynamics mitochondrion density plasticity imaging brain depression hypothesis therapy stratum radiatum pathophysiology

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