Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Paolo Peterlongo, none, IFOM, Fondazione Istituto FIRC di Oncologia Molecolare paolo.peterlongo@ifom.eu.
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  • Jenny Chang-Claude, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ).
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  • Kirsten B Moysich, Department of Cancer Prevention and Control, Roswell Park Cancer Institute.
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  • Anja Rudolph, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ).
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  • Rita K Schmutzler, Center for Molecular Medicine Cologne, University of Cologne.
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  • Jacques Simard, Centre Hospitalier Universitaire de Québec Research Center and Laval University.
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  • Penny Soucy, Centre Hospitalier Universitaire de Québec Research Center and Laval University.
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  • Rosalind A Eeles, Cancer Genetics, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust.
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  • Douglas F Easton, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge.
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  • Ute Hamann, Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ).
  • ,
  • Stefan Wilkening, Genomic Epidemiology, German Cancer Research Center (DKFZ).
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  • Bowang Chen, Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ)., Unknown
  • Matti A Rookus, Department of Epidemiology, The Netherlands Cancer Institute.
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  • Marjanka K Schmidt, Department of Epidemiology, The Netherlands Cancer Institute.
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  • Frederieke H van der Baan, Department of Epidemiology, The Netherlands Cancer Institute., Unknown
  • Amanda B Spurdle, Molecular Cancer Epidemiology Laboratory, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute.
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  • Logan C Walker, Department of Pathology, University of Otago., Unknown
  • Felicity Lose, Molecular Cancer Epidemiology Laboratory, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute.
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  • Ana-Teresa Maia, Department of Biomedical Sciences and Medicine, University of Algarve., Unknown
  • Marco Montagna, Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS.
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  • Laura Matricardi, Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS., Unknown
  • Jan Lubinski, Department of Genetics and Pathology, Pomeranian Medical University.
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  • Anna Jakubowska, Department of Genetics and Pathologyy, Pomeranian Medical University.
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  • Encarna B Gomez-Garcia, Department of Clinical Genetics, Maastricht University Medical Center.
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  • Olufunmilayo I Olopade, Center for Clinical Cancer Genetic, Department of Medicine, The University of Chicago.
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  • Robert L Nussbaum, Department of Medicine and Institute for Human Genetics, University of California, San Francisco., Unknown
  • Katherine L Nathanson, Department of Medicine, Abramson Cancer Center, University of Pennsylvania.
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  • Susan M Domchek, Department of Medicine, Abramson Cancer Center, University of Pennsylvania.
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  • Timothy R Rebbeck, Department of Epidemiology and Biostatistics, University of Pennsylvania.
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  • Banu K Arun, Department of Breast Medical Oncology, University of Texas M.D. Anderson Cancer Center.
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  • Beth Y Karlan, Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center.
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  • Sandra Orsulic, Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center.
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  • Jenny Lester, Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center.
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  • Wendy K Chung, Department of Pediatrics and Medicine, Columbia University.
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  • Alex Miron, Department of Genetics and Genomics, Case Western Reserve Medical School.
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  • Melissa C Southey, Genetic Epidemiology Laboratory, The University of Melbourne.
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  • David E Goldgar, Department of Dermatology, University of Utah School of Medicine.
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  • Saundra S Buys, Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah School of Medicine.
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  • Ramunas Janavicius, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics.
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  • Cecelia M Dorfling, Department of Genetics, University of Pretoria
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  • Elizabeth J van Rensburg, Department of Genetics, University of Pretoria
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  • Yuan Chun Ding, Beckman Research Institute, Department of Population Sciences, City of Hope.
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  • Susan L Neuhausen, Beckman Research Institute, Department of Population Sciences, City of Hope.
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  • Thomas V O Hansen, Center for Genomic Medicine, Copenhagen University Hospital., Denmark
  • Anne-Marie Gerdes, Department of Clinical Genetics, Copenhagen University Hospital.
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  • Bent Ejlertsen, Department of Oncology, Copenhagen University Hospital.
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  • Lars Jønson, Center for Genomic Medicine, Copenhagen University Hospital.
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  • Ana Osorio, Human Genetics Group, Spanish National Cancer Centre (CNIO).
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  • Cristina Martinez-Bouzas, Molecular Genetics Laboratory, Department of Biochemistry, Hospital de Cruces.
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  • Javier Benitez, Human Genetics Group, Spanish National Cancer Centre (CNIO).
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  • Edye E Conway, care of City of Hope Clinical Cancer Genetics Community Research Network, Saint Alphonsus Regional Medical Center., Unknown
  • Kathleen R Blazer, Clinical Cancer Genetics, City of Hope., Unknown
  • Jeffrey N Weitzel, Clinical Cancer Genetics, City of Hope.
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  • Siranoush Manoukian, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT).
  • ,
  • Bernard Peissel, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT).
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  • Daniela Zaffaroni, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT).
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  • Giulietta Scuvera, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT).
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  • Monica Barile, Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia.
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  • Filomena Ficarazzi, IFOM, Fondazione Istituto FIRC di Oncologia Molecolare.
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  • Frederique Mariette, IFOM, Fondazione Istituto FIRC di Oncologia Molecolare.
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  • Stefano Fortuzzi, IFOM, Fondazione Istituto FIRC di Oncologia Molecolare., Unknown
  • Alessandra Viel, Experimental Oncology 1, CRO Aviano National Cancer Institute.
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  • Giuseppe Giannini, Department of Molecular Medicine, Sapienza University.
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  • Laura Papi, Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence.
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  • Aline Martayan, Unit of Genetic Counseling, Medical Oncology Department, Istituto Nazionale Tumori Regina Elena., Unknown
  • Maria Grazia Tibiletti, UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria.
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  • Paolo Radice, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT).
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  • Athanassios Vratimos, Molecular Diagnostics Laboratory IRRP, National Centre for Scientific Research., Unknown
  • Florentia Fostira, Molecular Diagnostics Laboratory IRRP, National Centre for Scientific Research.
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  • Judy E Garber, Medical Oncology, Dana-Farber Cancer Institute.
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  • Alan Donaldson, Clinical Genetics Department, St Michael's Hospital.
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  • Carole Brewer, Royal Devon & Exeter Hospital.
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  • Claire Foo, Cheshire & Merseyside Clinical Genetics Service, Liverpool Women's NHS Foundation Trust.
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  • D Gareth R Evans, Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust.
  • ,
  • Debra Frost, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge.
  • ,
  • Diana Eccles, Cancer Sciences Division, Univeristy of Southampton, Southampton University Hospitals NHS Trust.
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  • Angela Brady, Kennedy-Galton Centre, North West Thames Regional Genetics Service., Unknown
  • Jackie Cook, Sheffield Clinical Genetics Service, Sheffield Children's Hospital.
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  • Marc Tischkowitz, Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital.
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  • Julian Adlard, Yorkshire Regional Centre for Cancer Studies.
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  • Julian Barwell, Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust.
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  • Lisa Walker, Oxford Regional Genetics Service.
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  • Louise Izatt, Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust.
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  • Lucy E Side, North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust.
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  • M John Kennedy, Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St. James's Hospital.
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  • Mark T Rogers, All Wales Medical Genetics Services, University Hospital of Wales.
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  • Mary E Porteous, South East of Scotland Regional Genetics Service.
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  • Patrick J Morrison, Centre for Cancer Research and Cell Biology, Queens University of Belfast, Belfast HSC Trust.
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  • Radka Platte, Department of Public Health and Primary Care, University of Cambridge.
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  • Rosemarie Davidson, Yorkhill Hospitals, Ferguson-Smith Centre for Clinical Genetics.
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  • Shirley V Hodgson, Medical Genetics Unit, St George's, University of London.
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  • Steve Ellis, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge.
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  • Trevor Cole, West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust.
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  • Andrew K Godwin, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center.
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  • Kathleen Claes, Center for Medical Genetics, Ghent University.
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  • Tom Van Maerken, Center for Medical Genetics, Ghent University., Unknown
  • Alfons Meindl, Department of Gynaecology and Obstetrics, Technical University Munich.
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  • Andrea Gehrig, Institute of Human Genetics, University Wurzburg.
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  • Christian Sutter, Institut of Humangenetics, University of Heidelberg.
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  • Christoph Engel, Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig.
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  • Dieter Niederacher, Obstetrics & Gynecology, Heinrich Heine University Düsseldorf.
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  • Doris Steinemann, Institute of Cell and Molecular Pathology, Hannover Medical School.
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  • Hansjoerg Plendl, Institute of Human Genetics, University Hospital of Schleswig-Holstein/University Kiel.
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  • Karin Kast, Department of Obstetrics and Gynecology, Technische Universität Dresden.
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  • Kerstin Rhiem, Center for Molecular Medicine Cologne (CMMC), University of Cologne.
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  • Nina Ditsch, Department of Obstetrics and Gynecology, Ludwig Maximilians University Munich.
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  • Norbert Arnold, Clinic of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein/University Kiel.
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  • Raymonda Varon-Mateeva, Institute of Human Genetics, Charite Campus Virchow-Klinikum Humbold Universität.
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  • Barbara Wappenschmidt, Center for Molecular Medicine Cologne (CMMC), University of Cologne.
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  • Shan Wang-Gohrke, Department of Gynaecology and Obstetrics, University of Ulm.
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  • Brigitte Bressac-de Paillerets, Service de Génétique, Institut de Cancerologie Gustave Roussy.
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  • Bruno Buecher, Department of Tumour Biology, Institut Curie, Université Paris-Descartes.
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  • Capucine Delnatte, Centre René Gauducheau.
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  • Claude Houdayer, Department of Tumor Biology, Institut Curie, Université Paris-Descartes.
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  • Dominique Stoppa-Lyonnet, Service de Génétique Oncologique, Institut Curie.
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  • Francesca Damiola, Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université Lyon 1.
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  • Isabelle Coupier, Unité d'Oncogénétique, CHU Arnaud de Villeneuve Montpellier.
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  • Laure Barjhoux, Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université Lyon 1.
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  • Laurence Venat-Bouvet, Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren.
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  • Lisa Golmard, Department of Tumour Biology, Institut Curie, Université Paris-Descartes.
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  • Nadia Boutry-Kryza, Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard.
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  • Olga M Sinilnikova, Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard.
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  • Olivier Caron, Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy.
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  • Pascal Pujol, Unité d'Oncogénétique, CHU Arnaud de Villeneuve Montpellier.
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  • Sylvie Mazoyer, Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université Lyon 1.
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  • Muriel Belotti, Department of Tumour Biology, Institut Curie, Université Paris-Descartes.
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  • Marion Piedmonte, Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute.
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  • Michael L Friedlander, Australia New Zealand Gynaecological Oncology Group (ANZGOG)., Unknown
  • Gustavo C Rodriguez, Division of Gynecologic Oncology, NorthShore University HealthSystem.
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  • Larry J Copeland, Department of Obstetrics and Gynecology, Ohio State University., Unknown
  • Miguel de la Hoya, Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC.
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  • Pedro Perez Segura, Department of Oncology, Hospital Clinico San Carlos, IdISSC., Unknown
  • Heli Nevanlinna, Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital.
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  • Kristiina Aittomäki, Department of Clinical Genetics, Helsinki University Central Hospital.
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  • Theo A M van Os, Department of Clinical Genetics, Academic Medical Center.
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  • Hanne E J Meijers-Heijboer, Department of Clinical Genetics, VU University Medical Centre.
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  • Annemarie H Van der Hout, Department of Genetics, University Medical Center Groningen, University of Groningen.
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  • Maaike P G Vreeswijk, Department of Human Genetics, Leiden University Medical Center (LUMC).
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  • Nicoline Hoogerbrugge, Department of Human Genetics, Radboud University Medical Center.
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  • Margreet G E M Ausems, Department of Medical Genetics, University Medical Centre Utrecht.
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  • Helena C Van Doorn, Erasmus University Medical Center Cancer Institute, Department of Obstetrics and Gynaecology, Erasmus University Medical Center., Unknown
  • J Margriet Collée, Department of Clinical Genetics, Erasmus University Medical Center.
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  • Edith Olah, Department of Molecular Oncology, National Institute of Oncology.
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  • Orland Díez, Oncogenetics, Vall d'Hebron Institute of Oncology (VHIO).
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  • Ignacio Blanco, Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology.
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  • Conxi Lazaro, Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology.
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  • Joan Brunet, Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI-Catalan Institute of Oncology.
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  • Lídia Feliubadaló, Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology.
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  • Cezary Cybulski, Department of Genetics and Pathology, Pomeranian Medical University.
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  • Jacek Gronwald, Department of Genetics and Pathology, Pomeranian Medical University.
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  • Katarzyna Durda, Department of Genetics and Pathology, Pomeranian Medical University.
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  • Katarzyna Jaworska-Bieniek, Department of Genetics and Pathology, Pomeranian Medical University.
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  • Grzegorz Sukiennicki, Department of Genetics and Pathology, Pomeranian Medical University., Unknown
  • Adalgeir Arason, Department of Pathology, Landspitali-University Hospital.
  • ,
  • Jocelyne Chiquette, Centre des maladies du sein Deschênes-Fabia, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec.
  • ,
  • Manuel R Teixeira, Department of Genetics, Portuguese Oncology Institute-Porto.
  • ,
  • Curtis Olswold, Department of Health Sciences Research, Mayo Clinic.
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  • Fergus J Couch, Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic.
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  • Noralane M Lindor, Department of Health Science Research, Mayo Clinic.
  • ,
  • Xianshu Wang, Department of Laboratory Medicine and Pathology, Mayo Clinic.
  • ,
  • Csilla I Szabo, Building 50, Room 5312, National Human Genome Research Institute, National Institutes of Health.
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  • Kenneth Offit, Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center.
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  • Marina Corines, Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center., Unknown
  • Lauren Jacobs, Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center., Unknown
  • Mark Robson, Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center.
  • ,
  • Liying Zhang, Diagnostic Molecular Genetics Laboratory, Department of Pathology, Memorial Sloan-Kettering Cancer Center.
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  • Vijai Joseph, Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center.
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  • Andreas Berger, Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna.
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  • Christian F Singer, Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna.
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  • Christine Rappaport, Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna.
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  • Daphne Geschwantler Kaulich, Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna.
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  • Georg Pfeiler, OB/GYN, Medical University of Vienna.
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  • Muy-Kheng M Tea, Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna.
  • ,
  • Catherine M Phelan, Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute.
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  • Mark H Greene, Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health.
  • ,
  • Phuong L Mai, Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health.
  • ,
  • Gad Rennert, Clalit National Cancer Control Center Carmel Medical Center and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology.
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  • Anna Marie Mulligan, Department of Laboratory Medicine and Pathobiology, University of Toronto.
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  • Gord Glendon, Ontario Cancer Genetics Network: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital.
  • ,
  • Sandrine Tchatchou, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital., Unknown
  • Irene L Andrulis, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital.
  • ,
  • Amanda Ewart Toland, Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University.
  • ,
  • Anders Bojesen, Department of Clinical Genetics, Vejle Hospital., Denmark
  • Inge Sokilde Pedersen, Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital., Denmark
  • Mads Thomassen, Dept. of Clinical Genetics, Odense University Hospital.
  • ,
  • Uffe Birk Jensen
  • Yael Laitman, Sheba Medical Center.
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  • Johanna Rantala, Department of Clinical Genetics, Karolinska University Hospital.
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  • Anna von Wachenfeldt, Department of Oncology, Karolinska University Hospital.
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  • Hans Ehrencrona, Department of Immunology, Genetics and Pathology, Uppsala University.
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  • Marie Stenmark Askmalm, Department of Clinical and Experimental Medicine, Linköping University.
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  • Ake Borg, Department of Oncology, Lund University.
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  • Karoline B Kuchenbaecker, Centre for Cancer Epidemiology, Department of Public Health, University of Cambridge.
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  • Lesley McGuffog, Centre for Cancer Epidemiology, Department of Public Health, University of Cambridge.
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  • Daniel Barrowdale, Centre for Cancer Epidemiology, Department of Public Health, University of Cambridge.
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  • Sue Healey, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute.
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  • Andrew Lee, Centre for Cancer Epidemiology, Department of Public Health, University of Cambridge.
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  • Paul D P Pharoah, Department of Oncology, University of Cambridge.
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  • Georgia Chenevix-Trench, Cancer Division, QIMR Berghofer Medical Research Institute.
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  • Antonis C Antoniou, Centre for Cancer Epidemiology, Department of Public Health, University of Cambridge.
  • ,
  • Eitan Friedman, Oncogenetics Unit, Sheba Medical Center.

Background: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and non-genetic modifying factors. In this study we evaluated the putative role of variants in many candidate modifier genes. Methods: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n=3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach. Results: The observed p-values of association ranged between 0.005-1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments. Conclusion: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers. Impact: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies.

Original languageEnglish
JournalCancer Epidemiology, Biomarkers & Prevention
Volume24
Issue1
Pages (from-to)308-316
Number of pages9
ISSN1055-9965
DOIs
Publication statusPublished - Jan 2015

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