COtab: Expedient and Safe Setup for Pd-Catalyzed Carbonylation Chemistry

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  • Hugo Collin, Universidade Federal de São Jõao Del-Rei
  • ,
  • Wallace Reis, UFMG
  • ,
  • Dennis Ulsøe Nielsen
  • ,
  • Anders Thyboe Lindhardt, Danish Technological Institute, Aarhus C
  • ,
  • Marcelo Valle, Universidade Federal de São Jõao Del-Rei, Brazil
  • Rossimiriam Freitas, UFMG, Brazil
  • Troels Skrydstrup
Bench-stable tablets (COtabs) have been developed for the rapid and safe production of carbon monoxide. The tablets can be made in less than 5 min without the use of a glovebox and only require a stock solution of an amine base to liberate a specific quantity of CO in a two-chamber system. The COtabs were tested in five different carbonylation reactions and provided similar yields compared to literature procedures. Finally, a gram-scale reaction was conducted, as well as 13C-isotope labeling of the anticancer drug, olaparib.
Original languageEnglish
JournalOrganic Letters
Volume21
Issue15
Pages (from-to)5775-5778
Number of pages4
ISSN1523-7060
DOIs
Publication statusPublished - May 2019

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