Aquaporin-2 membrane targeting: still a conundrum

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The targeting of the water channel aquaporin-2 (AQP2) to the apical plasma membrane of kidney collecting duct principal cells is regulated mainly by the antidiuretic peptide hormone arginine vasopressin (AVP). This process is of crucial importance for the maintenance of body water homeostasis. In this brief review we assess the role of cyclic adenosine monophosphate (cAMP) and discuss the emerging concept that type 2 AVP receptor (V2R)-mediated AQP2 trafficking is cAMP-independent.

Original languageEnglish
JournalAmerican Journal of Physiology: Renal Physiology
Volume312
Issue4
Pages (from-to)F744-F747
ISSN1931-857X
DOIs
Publication statusPublished - 1 Apr 2017

    Research areas

  • Animals, Aquaporin 2, Arginine Vasopressin, Body Water, Cell Membrane, Cyclic AMP, Epithelial Cells, Humans, Kidney Tubules, Collecting, Protein Transport, Receptors, Vasopressin, Second Messenger Systems, Water-Electrolyte Balance, Journal Article, Review

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