Simulations of membrane-bound diglycosylated human prion protein reveal potential protective mechanisms against misfolding

Publication: Research - peer-reviewJournal article

DOI

  • Chin Jung Cheng
    Chin Jung ChengUniversity of Washington, Seattle
  • Heidi Koldso
    Heidi KoldsoUniversity of Washington, Seattle
  • Marc W. Van der Kamp
    Marc W. Van der KampUniversity of Washington, Seattle
  • Birgit Schiott
  • Valerie Daggett
    Valerie DaggettUniversity of Washington, Seattle
Original languageEnglish
JournalJournal of Neurochemistry
Volume142
Issue number1
Pages (from-to)171-182
Number of pages12
ISSN0022-3042
DOIs
StatePublished - Jul 2017

    Keywords

  • membrane simulation, molecular dynamics, prion protein misfolding, MOLECULAR-DYNAMICS SIMULATIONS, BETA-SHEET, CELL-SURFACE, FULL-LENGTH, PATHOGENIC MUTATIONS, ANCHORED PRION, NUCLEIC-ACIDS, STERIC ZIPPER, EARLY STEPS, CONVERSION

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ID: 115156745