Microsomal drug-metabolizing enzymes in the olive baboon (papio anabis).

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  • Herman Autrup
  • Brenda J. Thurlow, Department of Pathology, Medical School, University of Nairobi, Nairobi, Chester Beatty Institute, Institute of Cancer Research, Royal Cancer Hospital, London, KenyaJohnston Wakhisi, Department of Pathology, Medical School, University of Nairobi, Nairobi, KenyaGerald P. Warwick, Department of Pathology, Medical School, University of Nairobi, Nairobi, Chester Beatty Institute, Institute of Cancer Research, Royal Cancer Hospital, London, Kenya
  • Institute of Environmental and Occupational Medicine
1.1. The activity of microsomal drug-metabolizing enzymes—azo reductase, nitroreductase, p-hydroxylation, N-demethylation, O-demethylation, NADPH cytochrome c reductase and cytochrome P P-450—in the olive baboon are lower than in other animal species, e.g. mouse, rat, guinea-pig.
2. 2. The level is comparable with the level in man for N-demethylation, azo reductase, O-demethylation and NADPH cytochrome c reductase.
3. 3. The ratio of the activity of the p-hydroxylation as compared with cytochrome P-450 is very similar in baboon and man.
4. 4. Arylsulfatase is localized in the lysosomal fraction and beta-glucuronidase is present more in the lysosomal than in the microsomal fraction.
Original languageEnglish
JournalComparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology
Volume50
Issue number3
Pages (from-to)385-390
Number of pages6
ISSN1096-4959
DOIs
StatePublished - 15 Mar 1975

    Research areas

  • baboon, drug-metabolizing enzymes, azo reductase, N-demethylation, O-demethylation, nitroreductase, p-hydroxylation, NADPH cytochrome c reductase, cytochrome P-450, arylsulfatase A and B, beta-glucuronidase, Papio anabis

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