Microsomal drug-metabolizing enzymes in the olive baboon (papio anabis).

Publication: ResearchJournal article

DOI

  • Herman Autrup
  • Brenda J. Thurlow
    Brenda J. ThurlowDepartment of Pathology, Medical School, University of Nairobi, NairobiChester Beatty Institute, Institute of Cancer Research, Royal Cancer Hospital, LondonKenya
  • Johnston Wakhisi
    Johnston WakhisiDepartment of Pathology, Medical School, University of Nairobi, NairobiKenya
  • Gerald P. Warwick
    Gerald P. WarwickDepartment of Pathology, Medical School, University of Nairobi, NairobiChester Beatty Institute, Institute of Cancer Research, Royal Cancer Hospital, LondonKenya
  • Institute of Environmental and Occupational Medicine
1.1. The activity of microsomal drug-metabolizing enzymes—azo reductase, nitroreductase, p-hydroxylation, N-demethylation, O-demethylation, NADPH cytochrome c reductase and cytochrome P P-450—in the olive baboon are lower than in other animal species, e.g. mouse, rat, guinea-pig.
2. 2. The level is comparable with the level in man for N-demethylation, azo reductase, O-demethylation and NADPH cytochrome c reductase.
3. 3. The ratio of the activity of the p-hydroxylation as compared with cytochrome P-450 is very similar in baboon and man.
4. 4. Arylsulfatase is localized in the lysosomal fraction and beta-glucuronidase is present more in the lysosomal than in the microsomal fraction.
Original languageEnglish
JournalComparative Biochemistry and Physiology. Part B: Biochemistry & Molecular Biology
Volume50
Issue number3
Pages (from-to)385-390
Number of pages6
ISSN1096-4959
DOIs
StatePublished - 15 Mar 1975

    Keywords

  • baboon, drug-metabolizing enzymes, azo reductase, N-demethylation, O-demethylation, nitroreductase, p-hydroxylation, NADPH cytochrome c reductase, cytochrome P-450, arylsulfatase A and B, beta-glucuronidase, Papio anabis

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