Decreased GABA levels in the symptomatic hemisphere after Transient Ischaemic Attack

Research output: ResearchConference abstract for conference

Background and aims:
In patients with stroke the GABA level is decreased in the lesioned hemisphere which may facilitate neurological recovery. In this study we aimed to determine the cortical levels of GABA and glutamate in patients after transient ischemic attack (TIA).


Methods:
Ten first-time TIA patients with unilateral motor symptoms from upper limb and 10 healthy subjects underwent Magnetic Resonance Spectroscopy with SPECIAL technique. GABA and glutamate were measured in the hand area of the primary motor cortex (M1) in the symptomatic hemisphere.


Results:
Both GABA:Cr (p=0.003) and Glutamate:Cr (p=0.0035) ratios were significantly lower in the symptomatic hemisphere of TIA patients than in healthy subjects. No difference was found in grey matter content within the scanned voxel (p=0.26)


Conclusion:
Even though the neurologigal function was reestablished, our study showed reduced GABA- and Glutamate ratios in the symptomatic hemisphere. In the affected hemisphere of TIA patients, the lower GABA level may facilitate re-establishment of normal function. This finding should be explored in future studies. MRS could be a useful biomarker in the acute assessment of patients with suspected TIA.


Disclosure: Nothing to disclose
Original languageEnglish
Publication year26 Jun 2017
StatePublished - 26 Jun 2017
Event3rd Congress of the European Academy of Neurology - Amsterdam 2017 - Amsterdam, Netherlands
Duration: 24 Jun 201727 Jun 2017

Conference

Conference3rd Congress of the European Academy of Neurology - Amsterdam 2017
CountryNetherlands
CityAmsterdam
Period24/06/201727/06/2017

See relations at Aarhus University Citationformats

ID: 119065317