Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation

Publication: Research - peer-reviewJournal article

  • Sarah Felice Evans
    Sarah Felice Evans
  • Krithi Irmady
    Krithi Irmady
  • Katya Ostrow
    Katya Ostrow
  • Taeho Kim
    Taeho Kim
  • Anders Nykjaer
  • Paul Saftig
    Paul Saftig
  • Carl Blobel
    Carl Blobel
  • Barbara L Hempstead
    Barbara L Hempstead
Original languageEnglish
JournalJournal of Biological Chemistry
Volume286
Issue number34
Pages (from-to)29556-67
Number of pages12
ISSN0021-9258
DOIs
StatePublished - 2011

    Keywords

  • ADAM Proteins, Adaptor Proteins, Vesicular Transport, Amino Acid Motifs, Amyloid Precursor Protein Secretases, Animals, Brain-Derived Neurotrophic Factor, Golgi Apparatus, HEK293 Cells, Humans, Lysosomes, Membrane Proteins, Mice, Mice, Knockout, Nerve Tissue Proteins, Neurons, Protein Structure, Tertiary, Protein Transport, Rats

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