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Frozen shoulder and risk of cancer: a population-based cohort study

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BACKGROUND: Frozen shoulder might be a complication or a presenting symptom of cancer. We examined the risk of a cancer diagnosis after an incident diagnosis of frozen shoulder.

METHODS: We used prospectively collected data from Danish registries to identify patients with frozen shoulder during 1995-2013 and followed them for the development of cancer.

RESULTS: We observed 2572 incident cancers among 29 098 frozen shoulder patients. The expected number of incident cancers in the general population was 2434. The 6-month cumulative incidence of any cancer was 0.70%, corresponding to a standardised incidence ratio (SIR) of 1.38 (95% confidence interval (CI): 1.19-1.58). Risk increases were highest for lung cancer (SIR=2.19, 95% CI: 1.48-3.13), breast cancer (SIR=1.51, 95% CI: 1.02-2.15), and non-Hodgkin's lymphoma (SIR=2.28, 95% CI: 1.09-4.20). The cumulative incidence of any cancer during the remainder of follow-up (>6 months to a maximum 18.9 years) was 24.8% with an SIR of 1.04 (95% CI: 1.00-1.08).

CONCLUSIONS: Frozen shoulder might be an early predictor for a subsequent cancer diagnosis.

Original languageEnglish
JournalB J C
Pages (from-to)144-147
Number of pages4
Publication statusPublished - 27 Jun 2017

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