Behaviour of [11C]R(-)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4

Publication: Research - peer-reviewJournal article

  • Christine A Parker
    Christine A Parker
  • Julian C Matthews
    Julian C Matthews
  • Roger N Gunn
    Roger N Gunn
  • Laurent Martarello
    Laurent Martarello
  • Vincent J Cunningham
    Vincent J Cunningham
  • David Dommett
    David Dommett
  • Stephen T Knibb
    Stephen T Knibb
  • Dirk Bender
  • Steen Jakobsen
  • John Brown
    John Brown
  • Antony D Gee
    Antony D Gee
Original languageEnglish
JournalSynapse (New York)
Volume55
Issue number4
Pages (from-to)270-9
Number of pages10
ISSN0887-4476
DOIs
StatePublished - 2005

    Keywords

  • 3',5'-Cyclic-AMP Phosphodiesterases, Affinity Labels, Animals, Binding, Competitive, Brain, Carbon Radioisotopes, Cell Membrane, Cyclic AMP, Cyclic Nucleotide Phosphodiesterases, Type 4, Male, Phosphodiesterase Inhibitors, Positron-Emission Tomography, Rats, Rats, Sprague-Dawley, Rolipram, Stereoisomerism, Subcellular Fractions, Sus scrofa

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