Access to 2,5-diamidopyrroles and 2,5-diamidofurans by Au(I)-catalyzed double hydroamination or hydration of 1,3-diynes

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A Au(I)-catalyzed hydroamination or hydration of 1,3-diynes to access 2,5-diamidopyrroles and 2,5-diamidofurans has been developed. This method can also be expanded to 2,5-disubstituted furans and 1,2,5-trisubstituted pyrroles including the formation of deuterated heterocycles and (18)O-labeled furans.
Original languageEnglish
JournalOrganic Letters
Pages (from-to)2758-2761
Number of pages4
Publication statusPublished - 2010

    Research areas

  • Amination, Catalysis, Combinatorial Chemistry Techniques, Cyclization, Diynes, Furans, Gold, Molecular Structure, Pyrroles

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