CRANIOFACIAL MORPHOLOGY AND DENTAL OCCLUSION IN ADULTS WITH OSTEOGENESIS IMPERFECTA: A COMPARISON ACCORDING TO SEVERITY OF DISEASE

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AIMS: To compare craniofacial characteristics and variation in dental occlusion according to severity of osteogenesis imperfecta (OI). OI is a rare inherited disease with fragility of bone and teeth because of abnormalities in the formation of collagen. METHODS: A total of 73 patients with a genetically confirmed diagnosis of OI were recruited in the department of medical endocrinology at Aarhus Universityhospital. Standardized profile cephalograms were obtained in 68 patients. Cephalometric analyses were performed and cephalometric variables were compared according to OI-severity (54 OI type 1(mild) versus 14 OI type 3 or 4 (severe)). The comparison was performed by multiple linear regression analyses with the cephalometric variable as outcome variable adjusted for the effect of age, gender, and family clustering. Patients had clinical photos taken: overjet, overbite, crossbite and posterior open bite were assessed. Statistical analyses by Fischer`s exact test. RESULTS: In comparison with mildly affected patients, the severely affected patients had significantly (p<0.05) reduced mean (sd) lengths sella-basion (mild: 49 (3.6); severe: 45 (3.1)), basion-bregma (mild: 156 (7.7); severe: 149 (10.3)), basion-lambda (mild: 132 (7.0); severe: 124 (8.6)) , and sella-lambda (mild: 136 (6.3); severe: 130 (8.5)), reduced mean (sd) thickness of the parietal theca (mild: 8 (1.8); severe: 6 (1.0)), a reduced maxillary mean (sd) length (mild: 95 mm(6.2); severe: 89 (8.3) and maxillary posterior mean (sd) height (mild: 50 (3.7); severe: 46 (4.1)), a reduced maxillary prognatism (mild: 83 (3.4); severe: 80 (3.4)), increased mean (sd) maxillary inclination (mild: 6 (4.1); severe: 12 (4.1), a reduced mandibular mean (sd) length (mild: 129 (7.2); severe: 120 (9.5)) and a reduced mean distance nasion-gnathion (mild: 129 (7.6); severe: 121 (10)). More severely than mildly affected patients had mandibular overjet (≤ 0 mm) (mild OI: 4%, severe OI 64%) and posterior cross bite (mild OI: 15%, severe OI: 88%). CONCLUSION The degree of deviation in neurocranial morphology is associated with the severity of OI. The morphology and position of the maxilla is more affected in severe OI than in mild OI, the maxilla being more retrusive and with reduced posterior height. Mandibular overjet is a dominant symptom in severe OI.
Translated title of the contributionKraniofacial morfologi og dental okklusion hos voksne med osteogenesis imperfecta: En sammenligning i forhold til sværhedsgrad af sygdommen
Original languageEnglish
Publication year15 Jun 2017
Publication statusPublished - 15 Jun 2017
EventEuropean Orthodontic Society Congress - Montreux, Switzerland
Duration: 6 Jun 201710 Jun 2017
Conference number: 93
http://www.eos2017.ch

Conference

ConferenceEuropean Orthodontic Society Congress
Number93
CountrySwitzerland
CityMontreux
Period06/06/201710/06/2017
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