Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Zeyan Liew
  • Beate Ritz, Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA ; Department of Environmental Health Sciences, Fielding School of Public Health, UCLA, Los Angeles, California, USA ; Department of Neurology, School of Medicine, UCLA, Los Angeles, California, USA., United States
  • Cathrine Carlsen Bach
  • Robert F Asarnow, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California, USA ; Department of Psychology, UCLA, Los Angeles, California, USA., United States
  • Bodil Hammer Bech
  • Ellen A Nohr, Forskningsenheden for Gynækologi og Obstetrik, Klinisk Institut, SDU,
  • Rossana Bossi
  • Tine Brink Henriksen
  • Eva Cecilie Bonefeld-Jørgensen
  • Jørn Olsen

BACKGROUND: Perfluoroalkyl substances (PFASs) are widespread persistent organic compounds that have been suggested to affect neurodevelopment.

OBJECTIVE: We aimed to evaluate whether prenatal exposure to PFASs is associated with IQ in children.

METHODS: We studied 1,592 pregnancies enrolled in the Danish National Birth Cohort (DNBC) during 1996-2002. Sixteen PFASs were measured in maternal plasma collected in early gestation. Child IQ was assessed at 5 y of age using the Wechsler Primary and Preschool Scales of Intelligence-Revised (WPPSI-R) administered by trained psychologists. Using multivariable linear regression models, we estimated the differences in child IQ scores according to PFAS concentration [per natural-log (ng/mL) unit increase or values categorized in quartiles].

RESULTS: Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were detected in all samples, and five additional PFASs were quantified in >80% of the samples. Overall, we found no strong associations between a natural-log unit increase in each of the seven PFASs we evaluated and child IQ scores. A few positive and negative associations were found in the sex-stratified PFAS quartile analyses, but the patterns were inconsistent.

CONCLUSION: Overall, we did not find consistent evidence to suggest prenatal exposure to PFASs to be associated with child IQ scores at 5 y of age in the DNBC. Some of the sex-specific observations warrant further investigation. Additional studies should examine offspring IQ at older ages and assess other functional cognitive and neuropsychiatric measures in addition to intelligence. Postnatal exposures to PFASs and mixture effects for PFASs and PFASs with other environmental pollutants should also be considered in future research. https://doi.org/10.1289/EHP2754.

Original languageEnglish
JournalEnvironmental Health Perspectives
Volume126
Issue number6
Pages (from-to)067004
Number of pages7
ISSN0091-6765
DOIs
StatePublished - 12 Jun 2018

See relations at Aarhus University Citationformats

ID: 128095559