The influence of HLA-types on disease progression among HIV-2 infected patients in Guinea-Bissau

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OBJECTIVES: HIV-2 is endemic in West Africa and is characterized by lower transmissibility due to lower viral load, and HIV-2 infected persons usually have a slower progression to AIDS. The mechanisms behind the slower disease progression are unknown. The main objective was to identify specific HLA class I and II alleles that may influence the disease progression of HIV-2 infection.

DESIGN: Cohort follow-up study.

METHODS: We used high resolution HLA typing of DNA from 437 antiretroviral treatment naïve HIV-2 infected patients from the Bissau HIV Cohort, Guinea-Bissau, to identify HLA alleles with an influence on HIV-2 disease progression. The effect of HLA-type on viral load and CD4 cell count was assessed initially by ranksum-test and t-test, followed by adjusted logistic regression and multivariable linear regression analysis, respectively.

RESULTS: Three alleles (HLA-B58:01, HLA-DPB110:01 and HLA-DRB111:01) were associated with lower possibility of detectable baseline plasma viral load (p = 0.002, p = 0.044 and p = 0.033, respectively), and no alleles were associated with higher possibility of detectable plasma viral load. HLA-DPB110:01 and HLA-DRB111:01 were in linkage disequilibrium (p = 0.047). Patients with heterozygous HLA types in all their HLA class I loci or in one or two loci were not more likely to have undetectable viral load compared with patients that were homozygous in all their class I loci after adjusting for sex and CD4 cell count (p = 0.93 and p = 0.88, respectively).

CONCLUSIONS: The three alleles HLA-B58:01, HLA-DPB110:01 and HLA-DRB111:01 may protect against HIV-2 disease progression towards AIDS.

Original languageEnglish
JournalAIDS
Volume32
Issue6
Pages (from-to)721-728
Number of pages8
ISSN0269-9370
DOIs
Publication statusPublished - 27 Mar 2018

    Research areas

  • Journal Article, Guinea-Bissau, HIV-2, viral load, West Africa, human leukocyte antigens, CD4 + cell counts, Genetic Predisposition to Disease, Follow-Up Studies, Humans, Middle Aged, HIV-2/immunology, Male, CD4 Lymphocyte Count, HLA Antigens/genetics, Disease Progression, Viral Load, HIV Infections/genetics, Alleles, Adult, Female

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