Dysconnection of right parietal and frontal cortex in neglect syndrome

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Dysconnection of right parietal and frontal cortex in neglect syndrome. / Dietz, Martin; Nielsen, Jørgen Feldbæk; Roepstorff, Andreas; Garrido, Marta.

In: Bioarxiv, 22.09.2017.

Research output: ResearchJournal article

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@article{778c51d142f94080a72fb7f624179b93,
title = "Dysconnection of right parietal and frontal cortex in neglect syndrome",
abstract = "A lesion to the right hemisphere of the brain often leads to perceptual neglect of the left side of the sensorium. The fact that lesions to different cortical regions lead to the same symptoms points to neglect as a dysconnection syndrome that may result from the dysconnection of a distributed network, rather than a disruption of computation in any particular brain region. To test this hypothesis, we used Bayesian analysis of effective connectivity based on electroencephalographic recordings in patients with left-sided neglect after a right-hemisphere lesion. While age-matched healthy controls showed a contralateral increase in connection strength between parietal and frontal cortex with respect to the laterality of the stimuli, neglect patients showed a dysconnection between parietal and frontal cortex in the right hemisphere when stimuli appeared on their neglected side, but preserved connectivity in the left hemisphere when stimuli appeared on their right. Crucially, this parieto-frontal feedback connectivity was aggravated in patients with more severe symptoms. In contrast, patients and controls did not show differences in the local connectivity within regions. These findings suggest that the aetiology of neglect may lie in the dysconnection of a distributed network, rather than the disruption of any particular brain region.",
keywords = "DCM, EEG, Bayesian, Neglect Syndrome, Predictive coding",
author = "Martin Dietz and Nielsen, {Jørgen Feldbæk} and Andreas Roepstorff and Marta Garrido",
year = "2017",
month = "9",
doi = "10.1101/192583",
journal = "Bioarxiv",

}

RIS

TY - JOUR

T1 - Dysconnection of right parietal and frontal cortex in neglect syndrome

AU - Dietz,Martin

AU - Nielsen,Jørgen Feldbæk

AU - Roepstorff,Andreas

AU - Garrido,Marta

PY - 2017/9/22

Y1 - 2017/9/22

N2 - A lesion to the right hemisphere of the brain often leads to perceptual neglect of the left side of the sensorium. The fact that lesions to different cortical regions lead to the same symptoms points to neglect as a dysconnection syndrome that may result from the dysconnection of a distributed network, rather than a disruption of computation in any particular brain region. To test this hypothesis, we used Bayesian analysis of effective connectivity based on electroencephalographic recordings in patients with left-sided neglect after a right-hemisphere lesion. While age-matched healthy controls showed a contralateral increase in connection strength between parietal and frontal cortex with respect to the laterality of the stimuli, neglect patients showed a dysconnection between parietal and frontal cortex in the right hemisphere when stimuli appeared on their neglected side, but preserved connectivity in the left hemisphere when stimuli appeared on their right. Crucially, this parieto-frontal feedback connectivity was aggravated in patients with more severe symptoms. In contrast, patients and controls did not show differences in the local connectivity within regions. These findings suggest that the aetiology of neglect may lie in the dysconnection of a distributed network, rather than the disruption of any particular brain region.

AB - A lesion to the right hemisphere of the brain often leads to perceptual neglect of the left side of the sensorium. The fact that lesions to different cortical regions lead to the same symptoms points to neglect as a dysconnection syndrome that may result from the dysconnection of a distributed network, rather than a disruption of computation in any particular brain region. To test this hypothesis, we used Bayesian analysis of effective connectivity based on electroencephalographic recordings in patients with left-sided neglect after a right-hemisphere lesion. While age-matched healthy controls showed a contralateral increase in connection strength between parietal and frontal cortex with respect to the laterality of the stimuli, neglect patients showed a dysconnection between parietal and frontal cortex in the right hemisphere when stimuli appeared on their neglected side, but preserved connectivity in the left hemisphere when stimuli appeared on their right. Crucially, this parieto-frontal feedback connectivity was aggravated in patients with more severe symptoms. In contrast, patients and controls did not show differences in the local connectivity within regions. These findings suggest that the aetiology of neglect may lie in the dysconnection of a distributed network, rather than the disruption of any particular brain region.

KW - DCM

KW - EEG

KW - Bayesian

KW - Neglect Syndrome

KW - Predictive coding

U2 - 10.1101/192583

DO - 10.1101/192583

M3 - Journal article

JO - Bioarxiv

T2 - Bioarxiv

JF - Bioarxiv

ER -