Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer

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Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer. / Okholm, Trine Line Hauge; Nielsen, Morten Muhlig; Hamilton, Mark; Christensen, Lise-Lotte; Vang, Søren; Hedegaard, Jakob; Hansen, Thomas Birkballe; Kjems, Jørgen; Dyrskjøt, Lars; Pedersen, Jakob Skou.

In: npj Genomic Medicine, Vol. 2, 36, 28.11.2017.

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@article{6104c74991fb4e74a59b72c0d4649950,
title = "Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer",
abstract = "The functions and biomarker potential of circular RNAs (circRNAs) in various cancer types are a rising field of study, as emerging evidence relates circRNAs to tumorigenesis. Here, we profiled the expression of circRNAs in 457 tumors from patients with non-muscle-invasive bladder cancer (NMIBC). We show that a set of highly expressed circRNAs have conserved core splice sites, are associated with Alu repeats, and enriched with Synonymous Constraint Elements as well as microRNA target sites. We identified 113 abundant circRNAs that are differentially expressed between high and low-risk tumor subtypes. Analysis of progression-free survival revealed 13 circRNAs, among them circHIPK3 and circCDYL, where expression correlated with progression independently of the linear transcript and the host gene. In summary, our results demonstrate that abundant circRNAs possess multiple biological features, distinguishing them from low-expressed circRNAs and non-circularized exons, and suggest that circRNAs might serve as a new class of prognostic biomarkers in NMIBC.",
author = "Okholm, {Trine Line Hauge} and Nielsen, {Morten Muhlig} and Mark Hamilton and Lise-Lotte Christensen and S{\o}ren Vang and Jakob Hedegaard and Hansen, {Thomas Birkballe} and J{\o}rgen Kjems and Lars Dyrskj{\o}t and Pedersen, {Jakob Skou}",
year = "2017",
month = "11",
day = "28",
doi = "10.1038/s41525-017-0038-z",
language = "English",
volume = "2",
journal = "npj Genomic Medicine",

}

RIS

TY - JOUR

T1 - Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer

AU - Okholm,Trine Line Hauge

AU - Nielsen,Morten Muhlig

AU - Hamilton,Mark

AU - Christensen,Lise-Lotte

AU - Vang,Søren

AU - Hedegaard,Jakob

AU - Hansen,Thomas Birkballe

AU - Kjems,Jørgen

AU - Dyrskjøt,Lars

AU - Pedersen,Jakob Skou

PY - 2017/11/28

Y1 - 2017/11/28

N2 - The functions and biomarker potential of circular RNAs (circRNAs) in various cancer types are a rising field of study, as emerging evidence relates circRNAs to tumorigenesis. Here, we profiled the expression of circRNAs in 457 tumors from patients with non-muscle-invasive bladder cancer (NMIBC). We show that a set of highly expressed circRNAs have conserved core splice sites, are associated with Alu repeats, and enriched with Synonymous Constraint Elements as well as microRNA target sites. We identified 113 abundant circRNAs that are differentially expressed between high and low-risk tumor subtypes. Analysis of progression-free survival revealed 13 circRNAs, among them circHIPK3 and circCDYL, where expression correlated with progression independently of the linear transcript and the host gene. In summary, our results demonstrate that abundant circRNAs possess multiple biological features, distinguishing them from low-expressed circRNAs and non-circularized exons, and suggest that circRNAs might serve as a new class of prognostic biomarkers in NMIBC.

AB - The functions and biomarker potential of circular RNAs (circRNAs) in various cancer types are a rising field of study, as emerging evidence relates circRNAs to tumorigenesis. Here, we profiled the expression of circRNAs in 457 tumors from patients with non-muscle-invasive bladder cancer (NMIBC). We show that a set of highly expressed circRNAs have conserved core splice sites, are associated with Alu repeats, and enriched with Synonymous Constraint Elements as well as microRNA target sites. We identified 113 abundant circRNAs that are differentially expressed between high and low-risk tumor subtypes. Analysis of progression-free survival revealed 13 circRNAs, among them circHIPK3 and circCDYL, where expression correlated with progression independently of the linear transcript and the host gene. In summary, our results demonstrate that abundant circRNAs possess multiple biological features, distinguishing them from low-expressed circRNAs and non-circularized exons, and suggest that circRNAs might serve as a new class of prognostic biomarkers in NMIBC.

U2 - 10.1038/s41525-017-0038-z

DO - 10.1038/s41525-017-0038-z

M3 - Journal article

VL - 2

JO - npj Genomic Medicine

T2 - npj Genomic Medicine

JF - npj Genomic Medicine

M1 - 36

ER -