AS3MT-mediated tolerance to arsenic evolved by multiple independent horizontal gene transfers from bacteria to eukaryotes

Publication: Research - peer-reviewJournal article

Standard

AS3MT-mediated tolerance to arsenic evolved by multiple independent horizontal gene transfers from bacteria to eukaryotes. / Palmgren, Michael; Engström, Karin; Hallström, Björn M.; Wahlberg, Karin; Søndergaard, Dan Ariel; Säll, Torbjörn; Vahter, Marie; Broberg, Karin.

In: PLOS ONE, Vol. 12, No. 4, 20.04.2017, p. e0175422.

Publication: Research - peer-reviewJournal article

Harvard

Palmgren, M, Engström, K, Hallström, BM, Wahlberg, K, Søndergaard, DA, Säll, T, Vahter, M & Broberg, K 2017, 'AS3MT-mediated tolerance to arsenic evolved by multiple independent horizontal gene transfers from bacteria to eukaryotes' PLOS ONE, vol 12, no. 4, pp. e0175422. DOI: 10.1371/journal.pone.0175422

APA

Palmgren, M., Engström, K., Hallström, B. M., Wahlberg, K., Søndergaard, D. A., Säll, T., ... Broberg, K. (2017). AS3MT-mediated tolerance to arsenic evolved by multiple independent horizontal gene transfers from bacteria to eukaryotes. PLOS ONE, 12(4), e0175422. DOI: 10.1371/journal.pone.0175422

CBE

Palmgren M, Engström K, Hallström BM, Wahlberg K, Søndergaard DA, Säll T, Vahter M, Broberg K. 2017. AS3MT-mediated tolerance to arsenic evolved by multiple independent horizontal gene transfers from bacteria to eukaryotes. PLOS ONE. 12(4):e0175422. Available from: 10.1371/journal.pone.0175422

MLA

Vancouver

Palmgren M, Engström K, Hallström BM, Wahlberg K, Søndergaard DA, Säll T et al. AS3MT-mediated tolerance to arsenic evolved by multiple independent horizontal gene transfers from bacteria to eukaryotes. PLOS ONE. 2017 Apr 20;12(4):e0175422. Available from, DOI: 10.1371/journal.pone.0175422

Author

Palmgren, Michael; Engström, Karin; Hallström, Björn M.; Wahlberg, Karin; Søndergaard, Dan Ariel; Säll, Torbjörn; Vahter, Marie; Broberg, Karin / AS3MT-mediated tolerance to arsenic evolved by multiple independent horizontal gene transfers from bacteria to eukaryotes.

In: PLOS ONE, Vol. 12, No. 4, 20.04.2017, p. e0175422.

Publication: Research - peer-reviewJournal article

Bibtex

@article{eda41888c66b4b2a85b8c7c0ea6f9a7b,
title = "AS3MT-mediated tolerance to arsenic evolved by multiple independent horizontal gene transfers from bacteria to eukaryotes",
author = "Michael Palmgren and Karin Engström and Hallström, {Björn M.} and Karin Wahlberg and Søndergaard, {Dan Ariel} and Torbjörn Säll and Marie Vahter and Karin Broberg",
year = "2017",
month = "4",
doi = "10.1371/journal.pone.0175422",
volume = "12",
pages = "e0175422",
journal = "PLOS ONE",
publisher = "public library of science",
number = "4",

}

RIS

TY - JOUR

T1 - AS3MT-mediated tolerance to arsenic evolved by multiple independent horizontal gene transfers from bacteria to eukaryotes

AU - Palmgren,Michael

AU - Engström,Karin

AU - Hallström,Björn M.

AU - Wahlberg,Karin

AU - Søndergaard,Dan Ariel

AU - Säll,Torbjörn

AU - Vahter,Marie

AU - Broberg,Karin

PY - 2017/4/20

Y1 - 2017/4/20

N2 - Organisms have evolved the ability to tolerate toxic substances in their environments, often by producing metabolic enzymes that efficiently detoxify the toxicant. Inorganic arsenic is one of the most toxic and carcinogenic substances in the environment, but many organisms, including humans, metabolise inorganic arsenic to less toxic metabolites. This multistep process produces mono-, di-, and trimethylated arsenic metabolites, which the organism excretes. In humans, arsenite methyltransferase (AS3MT) appears to be the main metabolic enzyme that methylates arsenic. In this study, we examined the evolutionary origin of AS3MT and assessed the ability of different genotypes to produce methylated arsenic metabolites. Phylogenetic analysis suggests that multiple, independent horizontal gene transfers between different bacteria, and from bacteria to eukaryotes, increased tolerance to environmental arsenic during evolution. These findings are supported by the observation that genetic variation in AS3MT correlates with the capacity to methylate arsenic. Adaptation to arsenic thus serves as a model for how organisms evolve to survive under toxic conditions.

AB - Organisms have evolved the ability to tolerate toxic substances in their environments, often by producing metabolic enzymes that efficiently detoxify the toxicant. Inorganic arsenic is one of the most toxic and carcinogenic substances in the environment, but many organisms, including humans, metabolise inorganic arsenic to less toxic metabolites. This multistep process produces mono-, di-, and trimethylated arsenic metabolites, which the organism excretes. In humans, arsenite methyltransferase (AS3MT) appears to be the main metabolic enzyme that methylates arsenic. In this study, we examined the evolutionary origin of AS3MT and assessed the ability of different genotypes to produce methylated arsenic metabolites. Phylogenetic analysis suggests that multiple, independent horizontal gene transfers between different bacteria, and from bacteria to eukaryotes, increased tolerance to environmental arsenic during evolution. These findings are supported by the observation that genetic variation in AS3MT correlates with the capacity to methylate arsenic. Adaptation to arsenic thus serves as a model for how organisms evolve to survive under toxic conditions.

U2 - 10.1371/journal.pone.0175422

DO - 10.1371/journal.pone.0175422

M3 - Journal article

VL - 12

SP - e0175422

JO - PLOS ONE

T2 - PLOS ONE

JF - PLOS ONE

IS - 4

ER -