Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis. / Sørensen, Mette ; Thinggaard, Mikael ; Nygaard, Marianne ; Dato, Serena ; Tan, Qihua ; Hjelmborg, Jacob ; Andersen-Ranberg, Karen ; Stevnsner, Tinna V. ; Bohr, Vilhelm ; Kimura, Masayuki ; Aviv, Abraham ; Christensen, Kaare ; Christiansen, Lene.
In: Aging Cell, Vol. 11, No. 2, 04.2012.Publication: Research - peer-review › Journal article
Cancer and Longevity-Is There a Trade-off? : A Study of Cooccurrence in Danish Twin Pairs Born 1900-1918. / Christensen, Kaare ; Pedersen, Jacob K ; Hjelmborg, Jacob V B ; Vaupel, James W. ; Stevnsner, Tinna V. ; Holm, Niels Vilstrup ; Skytthe, Axel.
In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 67A, No. 5, 05.2012, p. 489-494.Publication: Research - peer-review › Journal article
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity. / Soerensen, Mette ; Dato, Serano ; Tan, Qihua ; Thinggaard, Mikael ; Kleindorp, Rabea ; Bekman, Marian ; Suchiman, H Eka D ; Jacobsen, Rune ; McGue, Matt ; Stevnsner, Tinna ; Bohr, Vilhelm A ; de Craen, Anton J ; Westendorp, Rudi G J ; Schreiber, Stefan ; Slagboom, P Eline ; Nebel, Almut ; Vaupel, James W ; Christensen, Kaare ; Christiansen, Lene.
In: Age (Omaha), 2012.Publication: Research - peer-review › Journal article
Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease. / Diaz, Ricardo Gredilla ; Weissman, Lior ; Yang, JL ; Bohr, Vilhelm ; Stevnsner, Tinna V..
In: Neurobiology of Aging, Vol. 33, No. 4, 2012, p. 694-707.Publication: Research - peer-review › Journal article
DNA repair deficiency in neurodegeneration. / Jeppesen, Dennis Kjølhede ; Bohr, Vilhelm ; Stevnsner, Tinna V..
In: Progress in Neurobiology, Vol. 30, No. 94, 04.2011, p. 166-200.Publication: Research - peer-review › Review
The Human Suv3 Helicase Interacts with Replication Protein A and Flap Endonuclease 1 in the Nucleus.. / Venø, Susanne Trillingsgaard ; Kulikowicz, Thomasz ; Pestana, Cezar ; Stepien, Piotr ; Stevnsner, Tinna V. ; Bohr, Vilhelm.
In: Biochemical Journal, 2011.Publication: Research - peer-review › Journal article
WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-IDNA covalent complexes. / Patro, Birija Sankar ; Hougaard, Rikke Frøhlich ; Bohr, Vilhelm ; Stevnsner, Tinna V..
In: Journal of Cell Science, Vol. 124, 2011, p. 3967-3979.Publication: Research - peer-review › Journal article
Mitochondrial DNA repair and association with aging- an update. / Diaz, Ricardo Gredilla ; Bohr, Vilhelm ; Stevnsner, Tinna V..
In: Experimental Gerontology, Vol. 45, No. 7-8, 08.2010.Publication: Research - peer-review › Journal article
Regulation of WRN function and activity by sumoylation during the DNA damage response. / Hougaard, Rikke Frøhlich ; Jeppesen, Dennis Kjølhede ; Bohr, Vilhelm ; Stevnsner, Tinna V..
2010. Abstract from The interface between the Ubiquitin Family and the DNA damage Response, EMBO, Croatia.Publication: Research › Conference abstract for conference
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data.. / Sørensen, Mette ; Dato, S. ; Christensen, Kaare ; McGue, M. ; Stevnsner, Tinna V. ; Bohr, Vilhelm ; Christiansen, Lene.
In: Aging Cell, Vol. 9, No. 6, 12.2010, p. 1010-1017.Publication: Research - peer-review › Journal article
Cockayne Syndrome group B protein promotes mtDNA stability by maintaining the BER association with the mitochondrial membrane. / Aamann, Maria Aaen Diget ; Sørensen, M. ; Hvitby, Christina Poulsen ; Bergquist, B. ; Muftuoglu, Meltem ; Tian, J. ; de Souza-Pinto, N.C. ; Scheibye-Knudsen, M. ; Wilson III, D.M. ; Stevnsner, Tinna V. ; Bohr, Vilhelm.
In: F A S E B Journal, Vol. 24, No. 7, 2010, p. 2334-46.Publication: Research - peer-review › Journal article
Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions. / Gredilla, Ricardo ; Garm, Christian ; Holm, Rikke ; Bohr, Vilhelm A ; Stevnsner, Tinna.
In: Neurobiology of Aging, Vol. 31, No. 6, 2010, p. 993-1002.Publication: Research - peer-review › Journal article
Mitochondrial helicases and mitochondrial genome maintenance. / Aamann, Maria Diget ; de Souza-Pinto, Nadja C ; Kulikowicz, Tomasz ; Stevnsner, Tinna V ; Bohr, Vilhelm A.
In: Mechanisms of Ageing and Development, Vol. 131, No. 7-8, 2010, p. 503-10.Publication: Research - peer-review › Review
Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase. / Muftuoglu, Meltem ; Souza-Pinto, NC ; Dogan, A ; Aamann, Maria Aaen Diget ; Stevnsner, Tinna V. ; Rybanska, I ; Kirkali, G. ; Dizdaroglu, M. ; Bohr, Vilhelm.
In: Journal of Biological Chemistry, Vol. 284, 29.01.2009, p. 9270-9279.Publication: Research - peer-review › Journal article
A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserine: decrease in mitochondrial DNA repair activity during ageing. / Sørensen, Mette ; Diaz, Ricardo Gredilla ; Müller-Ohldach, Mathis ; Werner, Alexander ; Bohr, Vilhelm ; Osiewacz, Heinz D ; Stevnsner, Tinna V..
In: Mechanisms of Ageing and Development, Vol. 130, No. 8, 2009, p. 487-496.Publication: Research - peer-review › Journal article
Cockayne Syndrome Group B Protein and Chromatin Structure. / Aamann, Maria Aaen Diget ; Stevnsner, Tinna V..
In: Molecular Mechanisms of Cockayne Syndrome. Landes Bioscience, 2009. p. Chap. 3.Publication: Education › Book chapter
Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal. / Maddukuri, L ; Speina, E ; Christiansen, M ; Dudzinska, D ; Zaim, J ; Obtulowicz, T ; Kabaczyk, S ; Komisarski, M ; Bukowy, Z ; Szczegielniak, J ; Wojcik, A ; Kusmierek, J ; Stevnsner, Tinna V. ; Bohr, Vilhelm ; Tudek, B.
In: Mutation Research - Reviews, Vol. 666, 2009, p. 23-31.Publication: Research - peer-review › Journal article
Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal.. / Maddukuri, Lena ; Speina, Elżbieta ; Christiansen, Mette ; Dudzinska, Dominika ; Zaim, Jolanta ; Obtułowicz, Tomasz ; Kabaczyk, Sylwia ; Komisarski, Marek ; Bukowy, Zuzanna ; Szczegielniak, Jadwiga ; Wójcik, Andrzej ; Kuśmierek, Jaroslaw T. ; Stevnsner, Tinna V. ; Bohr, Vilhelm ; Tudek, Barbara.
In: Mutation Research - Reviews, Vol. 666, No. 1-2, 2009, p. 23-31.Publication: Research - peer-review › Journal article
Novel DNA mismatch-repair activity involving YB-1 in human mitochondria. / de Souza-Pinto, Nadja ; A. Mason, Penelope ; Hashiguchi, K ; Weismann, Lior ; Tian, J ; Guay, D ; Lebel, M ; Stevnsner, Tinna V. ; Rasmussen, Lene Juel ; Bohr, Vilhelm.
In: D N A Repair, Vol. 8, No. 6, 2009, p. 704-719.Publication: Research - peer-review › Journal article
The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. / Sørensen, Mette ; Christensen, Kaare ; Stevnsner, Tinna V. ; Christiansen, Lene.
In: Mechanisms of Ageing and Development, Vol. 130, No. 5, 2009.Publication: Research - peer-review › Journal article
Age-related changes in DNA repair in mouse cerebella mitochondria. / Diaz, Ricardo Gredilla ; Garm, Christian Hasselbalch ; Jensen, Rikke Holm ; Bohr, Vilhelm ; Stevnsner, Tinna V..
2008. Poster session presented at 1st International Genome Dynamics in Neuroscience Conference, Oslo, Norway.Publication: Research › Poster
Aging-from molecules to populations. / Sander, Miriam ; Avlund, Kirsten ; Lauritzen, Martin ; Gottlieb, Tina ; Halliwell, Barry ; Stevnsner, Tinna ; Wewer, Ulla ; Bohr, Vilhelm A.
In: Mechanisms of Ageing and Development, Vol. 129, No. 10, 2008, p. 614-23.Publication: Research - peer-review › Journal article
Aspects of Cockayne Syndrome group B protein functions and interactions. / Bohr, Vilhelm ; Thorslund, Tina ; Christiansen, Mette ; Muftuoglu, Meltem ; Stevnsner, Tinna V..
2008. Poster session presented at 3rd International Conference on Functional Genomics of Ageing, Palermo, Sicily, Italy.Publication: Research › Poster
DNA repair, mitochondria and Ageing. / Diaz, Ricardo Gredilla ; Garm, Christian Hasselbalch ; Bohr, Vilhelm ; Stevnsner, Tinna V..
2008. Poster session presented at 2nd International Genome Dynamics in Neuroscience Conference, Asilomar Conference center, Pacific Groove, United States.Publication: Research › Poster
Mitochondrial DNA, base excision repair and neurodegeneration. / de Souza-Pinto, Nadja C. ; Wilson III,, David M. ; Stevnsner, Tinna V. ; Bohr, Vilhelm.
In: D N A Repair, Vol. 7, 2008, p. 1098-1109.Publication: Research › Review
Mitochondrial DNA Repair in Mammalian Brain during Lifespan. / Simonsen, Casper ; Patro, Birija Sankar ; Diaz, Ricardo Gredilla ; Osiewacz, H.D. ; Bohr, Vilhelm ; Stevnsner, Tinna V..
2008. Poster session presented at MiMage/LINK-AGE Joint Summer School, Les Diablerets, Switzerland.Publication: Research › Poster
The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging. / Stevnsner, Tinna V. ; Muftuoglu, Meltem ; Aamann, Maria Aaen Diget ; Bohr, Vilhelm.
In: Mechanisms of Ageing and Development, Vol. 129, No. 7-8, 2008, p. 441-448.Publication: Research › Review
WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand. / Bukowy, Zuzanna Katarzyna ; A. Harrigan, Jeanine ; A. Ramsden, Dale ; Tudek, Barbara ; Bohr, Vilhelm ; Stevnsner, Tinna V..
In: Nucleic Acids Research, 2008, p. 1-13.Publication: Research - peer-review › Journal article
Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase. / Imam, S.Z. ; Indig, F.E. ; Cheng, W.H. ; Saxena, S.P. ; Stevnsner, Tinna V. ; Kufe, T. ; Bohr, Vilhelm.
In: Nucleis Acid Res., Vol. 35, 2007, p. 4941-4951.Publication: Research - peer-review › Journal article
Mitochondria as determinant of nucleotide metabolism and chromosomal stability. / Desler, C. ; Munch-Petersen, B. ; Stevnsner, Tinna V. ; Matsui, S.-I. ; Kulawiec, M. ; Singh, K. ; Rasmussen, L.J..
In: Mutation Research - Reviews, Vol. 625, 2007, p. 112-124.Publication: Research - peer-review › Journal article
Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal. / Frøhlich, Rikke F ; Veigaard, C. ; Andersen, Félicie Faucon ; McClendon, A.K. ; Gentry, A.K. ; Andersen, Anni Hangaard ; Osherroff, N. ; Stevnsner, Tinna V. ; Knudsen, Birgitta R..
In: Nucleic Acid Res., Vol. 35, 2007, p. 6170-6180.Publication: Research - peer-review › Journal article
Cockayne syndrome group B protein has novel strand annealing and exchange activities. / Muftuoglu, M. ; Sharma, S. ; Thorslund, Tina ; Stevnsner, Tinna V. ; Sørensen, Martin Mark ; Brosh, R.M. ; Bohr, Vilhelm.
In: Nucleic Acids Res. , Vol. 34, 2006, p. 295-304.Publication: Research - peer-review › Journal article
DNA repair, mitochondria, and neurodegeneration. / Weissman,, Lior ; de Souza-Pinto, Nadja C ; Stevnsner, Tinna V. ; Bohr, Vilhelm.
In: Neuroscience, No. 145, 2006, p. 1318-1329.Publication: Research - peer-review › Journal article
DNA-reparation - en grundlæggende faktor i aldring og cancerudvikling. / Rasmussen, Lene Juel ; Stevnsner, Tinna V. ; Bohr, Vilhelm.
In: Ugeskrift for Laeger, Vol. 168, No. 24, 2006, p. 2332-2335.Publication: Research - peer-review › Journal article
Human premature aging diseases: molecular biology to clinical diagnosis. / Gan, D.D. ; Hedayati, M. ; Stevnsner, Tinna V. ; Bohr, Vilhelm.
In: Prevention and treatment of age related diseases. ed. / Suresh Rattan ; M. Kassem. Springer, 2006.Publication: Research › Book chapter
Cooperation of the Cockayne syndrome group B protein and PARP-1 in the response to oxidative damage. / Thorslund, Tina ; Stevnsner, Tinna V. ; Bohr, Vilhelm.
2005. Poster session presented at Benzon Symposium 52: Cellular Responses to DNA Damage, København, Denmark.Publication: Research › Poster
Cooperation of the Cockayne syndrome group B protein and poly (ADP-ribose) polymerase 1 in the response to oxidative stress. / Thorslund, Tina ; von Kobbe, C. ; Harrigan, J.A. ; Indig, F.E. ; Christiansen, Mette ; Stevnsner, Tinna V. ; Bohr, Vilhelm.
In: Molecular and Cellular Biology, Vol. 25, 2005, p. 7625-7236.Publication: Research - peer-review › Journal article
Gene expression responses to DNA damage are alterd in human aging and in Werner Syndrome. / Kyng, Kasper ; May, A. ; Stevnsner, Tinna V. ; Becker, K.G. ; Kølvraa, Steen ; Bohr, Vilhelm.
In: Oncogene, Vol. 24, 2005, p. 5026-5042.Publication: Research - peer-review › Journal article
Identification of a physical and functional interaction between CSB and PARP-1A novel implication of CSB in the cellular response to oxidative DNA damage?. / Thorslund, Tina ; von Kobbe, Cayetano ; Harrigan, Jeanine A. ; Bohr, Vilhelm ; Stevnsner, Tinna V..
2005. Poster session presented at Keystone Symposia, Genome Instability and Repair, Taos, NM, United States.Publication: Research › Poster
Mitochondrial repair of oxidative damage and changes with aging. / Stevnsner, Tinna V. ; Jensen, Anne ; Thorslund, Tina ; deSouza-Pinto, Nadja ; Bohr, Vilhelm.
2005. Poster session presented at Benzon Symposium 52: Cellular Responses to DNA Damage, København, Denmark.Publication: Research › Poster
The Cockayne syndrome group B protein is a functional dimer. / Christiansen, Mette ; Thorslund, Tina ; Jochimsen, Bjarne ; Bohr, Vilhelm ; Stevnsner, Tinna V..
In: FEBS J., Vol. 272, 2005, p. 4306-4314.Publication: Research - peer-review › Journal article
Aldringens molekylærbiologi. / Stevnsner, T. ; Thorslund, T. ; Bohr, Vilhelm.
In: Aktuel Naturvidenskab, Vol. 1, 2004, p. 4-7.Publication: Research › Journal article
Forskning i aldringens molekylærbiologi. / Stevnsner, T. ; Bohr, Vilhelm.
In: Ny aldringsforskning - resultater og perspektiver. ISBN 87-90651-39-1. ed. Ældreforum, 2004. p. 19-23.Publication: Research › Report chapter
Cockaynes syndrome group B cellular and biochemical functions. / Licht, C. ; Stevnsner, T. ; Bohr, Vilhelm.
In: Am. J. Hum. Gen., Vol. 73, 2003, p. 1217-1239.Publication: Research › Review
Dansk Center for Molekylær Gerontologi. / Clark, B. ; Rattan, S. ; Stevnsner, T..
In: Aarhus Universitets Forskningsfond: Årsberetning 2002. Afdeling for Kunsthistorie, Institut for Æstetiske Fag, Aarhus Universitet, 2003. p. 18-19.Publication: Communication › Book chapter
Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein.. / Christiansen, Mette ; Stevnsner, Tinna V. ; Modin, C. ; Martensen, P.M. ; Brosh Jr., R. M. ; Bohr, Vilhelm.
In: Nucleic Acids Res. , Vol. 31, No. 3, 2003, p. 963-973.Publication: Research › Journal article
Functional consequences of mutations in the conserved SF2 motifs and posttranslational phosphorylation of the CSB protein. / Christiansen, M. ; Stevnsner, T. ; Modin, C. ; Martensen, P.M. ; Brosh Jr., R.M. ; Bohr, Vilhelm.
In: Nucl. Acids Res., Vol. 31, 2003, p. 963-973.Publication: Research - peer-review › Journal article
Mammalian OGG1 incises 8-oxoadenine opposite cytosine in nuclei and mitochondria, while a different glycosylase incises 8-oxoadenine opposite guanine in nuclei. / Jensen, A. ; Calvayrac, G. ; Karahalil, B. ; Bohr, Vilhelm ; Stevnsner, T..
In: Journal of Biological Chemistry, Vol. 278, 2003, p. 19541-19548.Publication: Research - peer-review › Journal article
Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product. / Sunesen, M. ; Stevnsner, T. ; Brosh Jr., R.M. ; Dianov, G. ; Bohr, Vilhelm.
In: Oncogene, Vol. 21, 2002, p. 3571-3578.Publication: Research - peer-review › Journal article
Mitochondrial repair of 8-oxoguanine and changes with aging. / Stevnsner, T. ; Thorslund, T. ; de Souza-Pinto, N.C. ; Bohr, Vilhelm.
In: Experimental Gerontology, Vol. 37, 2002, p. 1189-1196.Publication: Research - peer-review › Journal article
Mitochondrial repair of 8-oxoguanine is deficient in Cockayne Syndrome group B. / Stevnsner, T. ; Nyaga, S. ; de Souza-Pinto, N.C. ; van der Horst, G.T.J. ; Gorgels, T.G.M.F. ; Hogue, B.A. ; Thorslund, T. ; Bohr, Vilhelm.
In: Oncogene, Vol. 21, 2002, p. 8675-8682.Publication: Research - peer-review › Journal article
Mitochrondrial DNA repair of oxidative damage in mammalian cells. / Bohr, Vilhelm ; Stevnsner, T. ; Souza-Pinto, N..
In: Gene, Vol. 286, 2002, p. 127-134.Publication: Research › Review
Repair of 8-oxoG is slower in endogenous nuclear genes than in mitochondrial DNA and is without strand bias. / Thorslund, T. ; Sunesen, M. ; Bohr, Vilhelm ; Stevnsner, T..
In: D N A Repair, Vol. 1, 2002, p. 261-273.Publication: Research - peer-review › Journal article
The tumor suppressor protein p53 stimulates the formation of the human topoisomerase I double cleavage complex in vitro. / Søe, K. ; Hartmann, H. ; Schlott, B. ; Stevnsner, T. ; Grosse, F..
In: Oncogene, Vol. 21, 2002, p. 6614-6623.Publication: Research - peer-review › Journal article
A human topoisomerase I cleavage complex stimulates the formation of a nearby additional cleavage complex in vitro. / Søe, K. ; Dianov, G. ; Nasheuer, H.-P. ; Bohr, Vilhelm ; Grosse, F. ; Stevnsner, T..
In: Nucl. Acids Res., Vol. 29, 2001, p. 3195-3103.Publication: Research - peer-review › Journal article
BER in nuclear and mitochondrial DNA. / Dianov, G. ; Souza-Pinto, N. ; Nyaga, S.G. ; Thybo, T. ; Stevnsner, T. ; Bohr, Vilhelm.
In: Prog. Nucl. Acids Res. Mol. Biol., Vol. 68, 2001, p. 285-298.Publication: Research › Review
Repair of 8-oxodeoxyguanosine lesions in mitochrondrial DNA depends on oxoguanine DNA glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial DNA of OGG1-defective mice. / de Souza-Pinto, N.C. ; Eide, L. ; Hogue, B.A. ; Thybo, T. ; Stevnsner, T. ; Klungland, A. ; Seeberg, E. ; Bohr, Vilhelm.
In: Cancer Research, Vol. 61, 2001, p. 5378-5381.Publication: Research - peer-review › Journal article
Gene-specific DNA repair of pyrimidine dimers does not decline during cellular aging in vitro. / Christiansen, Mette ; Stevnsner, T. ; Bohr, Vilhelm ; Clark, B.F.C. ; Rattan, Suresh.
In: Exp. Cell Res., Vol. 256, 2000, p. 308-314.Publication: Research - peer-review › Journal article
Gene-specific DNA repair of pyrimidine dimers does not decline during cellular aging in vitro.. / Christiansen, Mette ; Stevnsner, Tinna V. ; Bohr, Vilhelm ; Clark, B. F. ; Rattan, Suresh.
In: Exp. Cell Res., Vol. 256, No. 1, 2000, p. 308-314.Publication: Research › Journal article
Molecular characterization of an acidic region deletion mutant of Cockayne syndrome group B protein. / Sunesen, M. ; Selzer, R.R. ; Brosh, R.M.Jr. ; Balajee, A.S. ; Stevnsner, T. ; Bohr, V.A..
In: Nucl. Acids Res., Vol. 28, 2000, p. 3151-3159.Publication: Research - peer-review › Journal article
