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Steffen Sinning

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  1. 2011
  2. Published

    P25α / TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity. / Fjorback, Anja Nawarecki ; Sundbye, Sabrina ; Dächsel, Justus C ; Sinning, Steffen ; Wiborg, Ove ; Jensen, Poul H.

    In: The F E B S Journal (Online), Vol. 278, No. 3, 01.02.2011, p. 493-505.

    Publication: Research - peer-review › Journal article

  3. Published

    Permanently positively charged antidepressants : Invention registered with Aarhus University and patent filed 23.08.2011 (AU-2010-634-398. Invention PoC granted from AU 07.02.2011. / Jensen, Marie (Inventor) ; Petersen, Annette Lind (Inventor) ; Nielsen, Maja Holch (Inventor) ; Omer, Saher (Inventor) ; Wiborg, Ove (Inventor) ; Sinning, Steffen (Inventor) ; Jensen, Henrik Helligsø (Inventor).

    Feb 07, 2011.

    Publication: Research › Patent

  4. Published

    Molekylære determinanter for ecstasy analogers selektivitet. / Wami, Ebisse Chalcissa ; Sinning, Steffen.

    2011. Poster session presented at Psykiatriens 6. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  5. Published

    Anti-afhængighedsstoffet Ibogains binding til serotonintransporteren. / Martens, Pernille ; Autzen, Henriette Elisabeth ; Schiøtt, Birgit ; Sinning, Steffen.

    2011. Poster session presented at Psykiatriens 6. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  6. Published

    Antidepressivas allosteriske effekt er afhængig af serotonintransporterens oligomerisering. / Møller, Pernille Thornild ; Said, Saida ; Nielsen, Maja Holch ; Ladegaard, Bente ; Severinsen, Kasper ; Sinning, Steffen.

    2011. Poster session presented at Psykiatriens 6. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  7. Published

    Characterization of the role of individual sodium binding sites in the human serotonin transporter. / Noer, Pernille Rimmer ; Severinsen, Kasper ; Vinberg, K.A. ; Wiborg, Ove ; Sinning, Steffen.

    2011. Poster session presented at SFB 35 – Symposium: Transmembrane Transporters in Health and Disease 2011, Vienna, Austria, Wien, Austria.

    Publication: Research › Poster

  8. Published

    Conformational change of the human Serotonin Transporter. / Bjerregaard, Henriette ; Severinsen, Kasper ; Søderhielm, P. ; Kristensen, A.S. ; Wiborg, Ove ; Sinning, Steffen.

    2011. Poster session presented at International School of Biophysics: Channels and, Italy.

    Publication: Research - peer-review › Poster

  9. Published

    Dicysteine Crosslinking in the human Serotonin Transporter. / Bjerregaard, Henriette ; Severinsen, Kasper ; Søderhielm, P. ; Kristensen, A.S. ; Wiborg, Ove ; Sinning, Steffen.

    2011. Poster session presented at SFB 35 – Symposium: Transmembrane Transporters in Health and Disease 2011, Vienna, Austria, Wien, Austria.

    Publication: Research - peer-review › Poster

  10. Published

    Et nyt regulatorisk motiv i serotonintransporteren. / Jensen, Vivian Paaske ; Sinning, Steffen ; Müller, Heidi Kaastrup.

    2011. Poster session presented at Psykiatriens 6. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  11. Published

    In vitro og in vivo evaluering af nye forbedrede antidepressiva. / Holch Nielsen, Maja ; Bouzinova, Elena ; Omer, Sahar ; Jensen, Marie ; Jensen, Henrik Helligsø ; Wiborg, Ove ; Sinning, Steffen.

    2011. Poster session presented at Psykiatriens 6. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  12. Published

    Kan den humane serotonintransporter låses?. / Bjerregaard, Henriette ; Severinsen, Kasper ; Söderheim, Pella ; Kristensen, Anders Skov ; Wiborg, Ove ; Sinning, Steffen.

    2011. Poster session presented at Psykiatriens 6. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  13. Published

    Key residues controlling conformational transitions in the serotonin transporter. / Møller, Pernille Thornild ; Severinsen, Kasper ; Koldsø, Heidi ; Rudnick, Gary ; Schiøtt, Birgit ; Wiborg, Ove ; Sinning, Steffen.

    2011. Poster session presented at SFB 35 – Symposium: Transmembrane Transporters in Health and Disease 2011, Vienna, Austria, Wien, Austria.

    Publication: Research › Poster

  14. Published

    Kinetic evaluation of substrate binding to the Leucine Transporter (LeuT); the apparent two-substrate model is a consequence of slow kinetics and non-equilibrated protein-ligand complexes. / Christiansen, Anja Bjerregaard ; Noer, Pernille Rimmer ; Sinning, Steffen.

    2011. Poster session presented at SFB 35 – Symposium: Transmembrane Transporters in Health and Disease 2011, Vienna, Austria, Wien, Austria.

    Publication: Research › Poster

  15. Published

    Molecular determinants for ecstasy analogue selectivity. / Wami, Ebisse Chalcissa ; Sinning, Steffen.

    2011. Poster session presented at SFB 35 – Symposium: Transmembrane Transporters in Health and Disease 2011, Vienna, Austria, Wien, Austria.

    Publication: Research › Poster

  16. Published

    Synthesis of 3,7 disubstituted Imipramine Analogues via Palladium Catalysed Amination/Cyclisation and Evaluation of Their Inhibition of Monoamine Transporters. / Christensen, H. ; Schjøth-Eskensen, C. ; Jensen, Marie ; Sinning, Steffen ; Jensen, Henrik Helligsø.

    In: Chemistry: A European Journal, Vol. 17, 2011, p. 10618-10627.

    Publication: Research - peer-review › Journal article

  17. Published

    Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release. / Koldsø, Heidi ; Noer, Pernille ; Grouleff, Julie ; Autzen, Henriette Elisabeth ; Sinning, Steffen ; Schiøtt, Birgit.

    In: P L o S Computational Biology, Vol. 7, No. 10, 2011, p. e1002246.

    Publication: Research - peer-review › Journal article

  18. 2010
  19. Published

    Binding and Orientation of Tricyclic Antidepressants within the Central Substrate Site of the Human Serotonin Transporter. / Sinning, Steffen ; Musgaard, Maria ; Jensen, Marie ; Severinsen, Kasper ; Celik, Leyla ; Koldsoe, Heidi ; Meyer, Tine ; Bols, Mikael ; Jensen, Henrik Helligsoe ; Schiøtt, Hanne Birgit ; Wiborg, Ove.

    In: Journal of Biological Chemistry, Vol. 285, No. 11, 2010, p. 8363-8374.

    Publication: Research - peer-review › Journal article

  20. Published

    Characterization of the role of individual sodium binding sites in the human serotonin transporter. / Noer, Pernille Rimmer ; Severinsen, Kasper ; Vinberg, KA ; Wiborg, Ove ; Sinning, Steffen.

    2010. Poster session presented at Annual Meeting 2010 of Society for Neuroscience, San Diego, United States.

    Publication: Research › Poster

  21. Published

    Den ekstracellulære gates rolle i serotonin transport og stabil binding af antidepressiva. / Martens, Pernille ; Wiborg, Ove ; Sinning, Steffen.

    2010. Poster session presented at Psykiatriens 5. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  22. Published

    Et nyt regulatorisk motiv i serotonintransporteren. / Jensen, Vivian Paaske ; Wiborg, Ove ; Sinning, Steffen ; Müller, Heidi Kaastrup.

    2010. Poster session presented at Psykiatriens 5. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  23. Published

    In vitro evaluering af nye potentielt forbedrede antidepressiva. / Nielsen, Maja H ; Severinsen, Kasper ; Jensen, Marie ; Jensen, Henrik Helligsø ; Wiborg, Ove ; Sinning, Steffen.

    2010. Poster session presented at Psykiatriens 5. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  24. Published

    Key residues controlling conformational transitions in the human serotonin transporter. / Severinsen, Kasper ; Koldsø, Heidi ; Rosenberg, Raben ; Schiøtt, Birgit ; Rudnick, G ; Wiborg, Ove ; Sinning, Steffen.

    2010. Poster session presented at Gordon Research Conference, .

    Publication: Research › Poster

  25. Published

    Konformationsændringer i serotonintransporteren som basis for effektiv binding af antidepressiva. / Severinsen, Kasper ; Koldsø, Heidi ; T Møller, Pernille ; Schiøtt, Birgit ; Rudnick, Gary ; Sinning, Steffen.

    2010. Poster session presented at Psykiatriens 5. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  26. Published

    Molekylære determinanter for ecstasy-analogers selektivitet. / Wiborg, Ove ; Sinning, Steffen ; Wami, Ebisse Chalchissa.

    2010. Poster session presented at Psykiatriens 5. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  27. Published

    Natrium ioners rolle for transport af substrat og antidepressivas binding i den humane serotonin trabsporter. / Noer, Pernille ; Severinsen, Kasper ; Vinberg, Katrine A ; Wiborg, Ove ; Sinning, Steffen.

    2010. Poster session presented at Psykiatriens 5. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  28. Published

    The two enantiomers of citalopram bind to the human serotonin transporter in reversed orientations. / Koldsø, Heidi ; Severinsen, Kasper ; Tran, Thuy Tien ; Celik, Leyla ; Jensen, Henrik Helligsø ; Wiborg, Ove ; Schiøtt, Birgit ; Sinning, Steffen.

    In: American Chemical Society. Journal, Vol. 132, No. 4, 2010, p. 1311-22.

    Publication: Research - peer-review › Journal article

  29. 2009
  30. Published

    An extended study of dimeric phenyl tropanes. / Nielsen, Susan ; Pedersen, Christian M ; Hansen, Signe Grann ; Petersen, Mikkel Due ; Sinning, Steffen ; Wiborg, Ove ; Jensen, Henrik Helligsø ; Bols, Mikael.

    In: Bioorganic & Medicinal Chemistry, Vol. 17, No. 14, 2009, p. 4900-9.

    Publication: Research - peer-review › Journal article

  31. Published

    Det vestibulære bindingssteds rolle for allosterisk modulation af antidepressiva bundet til serotonin transporteren. / Sinning, Steffen.

    2009. Poster session presented at Psykiatriens Forskningsdag 2009, Århus, Denmark.

    Publication: Research › Poster

  32. 2008
  33. Published

    A Biochemically Validated Induced Fit Docking Model of Phenylpiperazine in a hSERT homology model. / Sinning, Steffen ; Severinsen, Kasper.

    2008. Poster session presented at Society for Neuroscience, .

    Publication: Research › Poster

  34. Published

    Binding of Serotonin to the Human Serotonin Transporter. Molecular Modeling and Experimental Validation.. / Celik, Leyla ; Sinning, Steffen ; Severinsen, Kasper ; Hansen, Carsten G. ; Møller, Maria S. ; Bols, Mikael ; Wiborg, Ove ; Schiøtt, Birgit.

    In: American Chemical Society. Journal, 2008, p. 3853-3865.

    Publication: Research - peer-review › Journal article

  35. Published

    Binding of 1-Phenylpiperazine to the human Serotonin Transporter : A computational study. / Kraft, Johan Frederik ; Koldsø, Heidi ; Sinning, Steffen ; Severinsen, Kasper ; Wiborg, Ove ; Schiøtt, Hanne Birgit.

    2008. Poster session presented at ISQBP 2008, .

    Publication: Research › Poster

  36. Published

    Binding of 1-Phenylpiperazineto the human Serotonin Transporter : A computational study. / Kraft, Johan Frederik ; Koldsø, Heidi ; Sinning, Steffen ; Wiborg, Ove ; Schiøtt, Hanne Birgit.

    2008. Poster session presented at EMBO workshop, Paris, France.

    Publication: Research › Poster

  37. Published

    Binding of 1-Phenylpiperazineto the human Serotonin Transporter : A computational study. / Kraft, Johan Frederik ; Koldsø, Heidi ; Sinning, Steffen ; Severinsen, Kasper ; Wiborg, Ove ; Schiøtt, Hanne Birgit.

    2008. Poster session presented at iNANO autumn school 2008, .

    Publication: Research › Poster

  38. Published

    Characterisation of the zebrafish serotonin transporter functionally links TM10 to the ligand binding site.. / Severinsen, Kasper ; Müller, Heidi Kaastrup ; Wiborg, Ove ; Sinning, Steffen.

    In: Journal of Neurochemistry, 2008.

    Publication: Research - peer-review › Journal article

  39. Published

    How Do Tricyclic Antidepressants Bind in the Human Serotonin Transporter? : Molecular Modelling Studies and Biochemical Validation. / Celik, Leyla ; Musgaard, Maria ; Koldsø, Heidi ; Sinning, Steffen ; Severinsen, Kasper ; Wiborg, Ove ; Schiøtt, Hanne Birgit.

    2008. Poster session presented at Biophysical Society Annual Meeting, Long Beach, United States.

    Publication: Research › Poster

  40. Published

    How do Tricyclic Antidepressants Bind in the Human Serotonin Transporter? : Molecular Modelling Studies with Biochemical Validation. / Musgaard, Maria ; Celik, Leyla ; Koldsø, Heidi ; Sinning, Steffen ; Severinsen, Kasper ; Wiborg, Ove ; Schiøtt, Hanne Birgit.

    2008. Poster session presented at ISQBP President's Meeting, Ascona, Switzerland.

    Publication: Research › Poster

  41. Published

    Orientering af S- og R-citalopram i serotonintransporteren - Computermodeller og biokemisk validering. / Severinsen, Kasper ; Koldsø, Heidi ; Tran, M. ; Sinning, Steffen ; Jensen, Henrik Helligsø ; Schiøtt, Hanne Birgit ; Wiborg, Ove.

    2008. Poster session presented at Orientering af S- og R-citalopram i serotonintransporteren - Computermodeller og biokemisk validering, Risskov, Denmark.

    Publication: Research › Poster

  42. Published

    Serotonin transporterens ionafhængighed. / Noer, Pernille Rimmer ; Sinning, Steffen ; Vinberg, K.A. ; Hansen, Carsten Gram ; Wiborg, Ove.

    2008. Poster session presented at Psykiatriens 3. Forskningsdag, Risskov, Denmark.

    Publication: Research › Poster

  43. Published

    Substrate Binding and Dynamics in the Human Serotonin Transporter. / Koldsø, Heidi ; Celik, Leyla ; Sinning, Steffen ; Severinsen, Kasper ; Wiborg, Ove ; Schiøtt, Hanne Birgit.

    2008. Poster session presented at ISQBP 2008, Ascona, Switzerland.

    Publication: Research › Poster

  44. Published

    Tricyclic antidepressant binding to the human serotonin transporter. / Sinning, Steffen ; Severinsen, Kasper ; Hansen, Carsten Gram ; Celik, Leyla ; Musgaard, Maria ; Koldsø, Heidi ; Jensen, M ; Jensen, Henrik Helligsø ; Schiøtt, Hanne Birgit ; Wiborg, Ove.

    2008. Abstract from Gordon Research Conference, Membrane Transport Proteins, Il Ciocco, Italy.

    Publication: Research › Conference abstract for conference

  45. Published

    Tricykliske antidepressivas binding til den humane serotonin transporter. / Sinning, Steffen ; Severinsen, Kasper ; Celik, Leyla ; Musgaard, Maria ; Koldsø, Heidi ; Schiøtt, Hanne Birgit ; Wiborg, Ove ; Hansen, Carsten Gram ; Jensen, M ; Jensen, H. H..

    2008. Abstract from Psykiatriens 3. Forskningsdag, Risskov, Denmark.

    Publication: Research › Conference abstract for conference

  46. 2007
  47. Published

    Binding of Antidepressants and Psycostimulants in the Human Serotonin Transporter. / Koldsø, Heidi ; Musgaard, Maria ; Celik, Leyla ; Sinning, Steffen ; Severinsen, Kasper ; Vinberg, Katrine A. ; Wiborg, Ove ; Schiøtt, Hanne Birgit.

    2007. Poster session presented at iNANO Autumn School 2007, .

    Publication: Research › Poster

  48. Published

    High dopamine transporter selectively can be displayed by remarkably simple non-nitrogen containing inhibitors. / Sinning, Steffen ; Boye, Søren Valdgård ; Wiborg, Ove ; Ortega-Caballero, F ; Jensen, HH ; Bols, Mikael.

    In: Bioorg. Med. Chem. Lett., Vol. 17, No. 21, 2007, p. 6019-6025.

    Publication: Research - peer-review › Journal article

  49. Published

    High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors. / Boye, Søren Valdgård ; Ortega-Caballero, Fernando ; Sinning, Steffen ; Wiborg, Ove ; Jensen, Henrik Helligsø ; Bols, Mikael.

    In: Bioorg. Med. Chem. Lett., Vol. 17, No. 21, 2007, p. 6019-6025.

    Publication: Research - peer-review › Journal article

  50. Published

    Insights into Binding of Antidepressants to the Human Serotonin Transporter. / Koldsø, Heidi ; Musgaard, Maria ; Celik, Leyla ; Sinning, Steffen ; Severinsen, Kasper ; Hansen, Carsten Gram ; Wiborg, Ove ; Schiøtt, Hanne Birgit.

    2007. Poster session presented at  5th iNANO Annual Meeting, .

    Publication: Research › Poster

  51. Published

    QSAR studies and pharmacophore identification for acrylsubstituted cycloalkenecarboxylic acid methyl esters with affinity for the human dopamine transporter. / Sinning, Steffen ; Christensen, Helena Staunstrup ; Boye, Søren Valdgård ; Thingaard, Jacob ; Wiborg, Ove ; Schiøtt, Birgit ; Bols, Mikael.

    In: Bioorganic & Medicinal Chemistry, Vol. 15, 2007, p. 5262-5274.

    Publication: Research - peer-review › Journal article

  52. Published

    Synthesis, inhibition and binding of simple non-nitrogen inhibitors og monoamine transporters. / Sinning, Steffen ; Petersen, Michael Due ; Boye, Søren Valdgård ; Nielsen, Erik Holm ; Willumsen, Jeanette ; Wiborg, Ove ; Bols, Mikael.

    In: Bioorganic & Medicinal Chemistry, Vol. 15, No. 12, 2007, p. 4159-4174.

    Publication: Research - peer-review › Journal article

  53. 2006
  54. Published

    An experimentally supported homology model for the antidepressant binding site on the human serotonin transporter : Poster. / Sinning, Steffen ; Severinsen, Kasper ; Hansen, Carsten Gram ; Celik, Leyla ; Musgaard, M ; Koldsø, H ; Schiøtt, Birgit ; Rosenberg, Raben ; Wiborg, Ove.

    In: 2006 Neuroscience Meeting Planner. Vol. 531.6/E24 2006.

    Publication: Research › Conference abstract in proceedings

  55. Published

    Binding of Serotonin in a Homology Model of the Serotonin Transporter. / Schiøtt, Birgit ; Celik, Leyla ; Sinning, Steffen ; Wiborg, Ove.

    2006. Poster session presented at 1st European Chemistry Congress, Budapest, Hungary.

    Publication: Research › Poster

  56. Published

    Homology modeling of the human serotonin transporter structure and the substrate binding site. / Sinning, Steffen ; Celik, Leyla ; Severinsen, Kasper ; Hansen, Carsten Gram ; Wiborg, Ove ; Schiøtt, Birgit.

    In: 2006 Neuroscience Meeting Planner. Vol. 531.7/E25 2006.

    Publication: Research › Conference abstract in proceedings

  57. 2005
  58. Published

    Characterisation of the ligand binding site of the human serotonin transporter. / Sinning, S..

    Aarhus Universitet, 2005.

    Publication: Research › Ph.d. thesis

  59. 2004
  60. Published

    Two- and three dimensional combinatorial chemistry from multicomponent grignard reagents. / Bülow, A. ; Sinning, S. ; Wiborg, O. ; Bols, M..

    In: J. Comb. Chem., Vol. 6, No. 4, 2004, p. 509-519.

    Publication: Research › Journal article

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