Simon Glerup

  1. 2018
  2. E-pub ahead of print
  3. E-pub ahead of print

    Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner. / Højland, Anne; Richner, Mette; Mølgaard, Simon; Dieu, Ruthe Storgaard; Eskelund, Amanda; Nykjær, Anders; Nyengaard, Jens Randel; Lykkesfeldt, Jens; Glerup, Simon; Nielsen, Morten Schallburg.

    In: Behavioural Brain Research, 13.04.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. Published

    Investigation of serum levels of sortilin in response to antidepressant treatment. / Buttenschøn, Henriette Nørmølle; Nielsen, Marit; Glerup, Simon; Mors, Ole.

    In: Acta Neuropsychiatrica, Vol. 30, No. 2, 04.2018, p. 111-116.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. E-pub ahead of print

    Exploring the sortilin related receptor, SorLA, in depression. / Buttenschøn, Henriette N; Elfving, Betina; Nielsen, Marit; Skeldal, Sune; Kaas, Mathias; Mors, Ole; Glerup, Simon.

    In: Journal of affective disorders, Vol. 232, 21.02.2018, p. 260-267.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. E-pub ahead of print

    Highly segregated localization of the functionally related vps10p receptors sortilin and SorCS2 during neurodevelopment. / Boggild, Simon; Molgaard, Simon; Glerup, Simon; Nyengaard, Jens Randel.

    In: Journal of Comparative Neurology, 06.02.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. 2017
  8. Published

    Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. / Gustafsen, Camilla; Olsen, Ditte; Vilstrup, Joachim; Lund, Signe; Reinhardt, Anika; Wellner, Niels; Larsen, Torben; Andersen, Christian B F; Weyer, Kathrin; Li, Jin-Ping; Seeberger, Peter H; Thirup, Søren; Madsen, Peder; Glerup, Simon.

    In: Nature Communications, Vol. 8, No. 1, 11.09.2017, p. 503.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    Progranulin gene variation affects serum progranulin levels differently in Danish bipolar individuals compared with healthy controls. / Buttenschøn, Henriette N; Nielsen, Marit N; Thotakura, Gangadaar; Lee, Chris W; Nykjær, Anders; Mors, Ole; Glerup, Simon.

    In: Psychiatric Genetics, Vol. 27, No. 3, 06.2017, p. 89-95.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    Physiological and therapeutic regulation of PCSK9 activity in cardiovascular disease. / Glerup, Simon; Schulz, Rainer; Laufs, Ulrich; Schlueter, Klaus-Dieter.

    In: Basic Research in Cardiology, Vol. 112, No. 3, 32, 05.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  11. 2016
  12. Published

    Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals. / Molgaard, Simon; Demontis, Ditte; Nicholson, Alexandra M; Finch, Nicole A; Petersen, Ronald C; Petersen, Claus M; Rademakers, Rosa; Nykjaer, Anders; Glerup, Simon.

    In: Experimental gerontology, Vol. 84, 11.2016, p. 96-100.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    Whole-Exome Sequencing Reveals Increased Burden of Rare Functional and Disruptive Variants in Candidate Risk Genes in Individuals With Persistent Attention-Deficit/Hyperactivity Disorder. / Demontis, Ditte; Lescai, Francesco; Børglum, Anders; Glerup, Simon; Østergaard, Søren Dinesen; Mors, Ole; Li, Qibin; Liang, Jieqin; Jiang, Hui; Li, Yingrui; Wang, Jun; Lesch, Klaus-Peter; Reif, Andreas; Buitelaar, Jan K; Franke, Barbara.

    In: American Academy of Child and Adolescent Psychiatry. Journal, Vol. 55, No. 6, 06.2016, p. 521-3.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. Published

    Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model. / Bøttger, Pernille; Pedersen, Simon Glerup; Gesslein, Bodil; Illarionova, Nina; Isaksen, Toke Jost; Heuck, Anders; Clausen, Bettina Hjelm; Füchtbauer, Ernst-Martin; Gramsbergen, Jan Bert; Gunnarson, Eli; Aperia, Anita; Lauritzen, Martin; Lambertsen, Kate Lykke; Nissen, Poul; Lykke-Hartmann, Karin.

    In: Scientific Reports, Vol. 6, No. 22047, 25.02.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. Published

    Cognitive deficits caused by a disease-mutation in the α3 Na(+)/K(+)-ATPase isoform. / Holm, Thomas Hellesøe; Isaksen, Toke Jost; Pedersen, Simon Glerup; Heuck, Anders; Bøttger, Pernille; Füchtbauer, Ernst-Martin; Nedergaard, Steen Torben; Nyengaard, Jens Randel; Andreasen, Mogens; Nissen, Poul; Lykke-Hartmann, Karin.

    In: Scientific Reports, Vol. 6, No. 31972, 2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    Detection of phosphorylated Akt and MAPK in cell culture assays. / Molgaard, Simon; Ulrichsen, Maj; Olsen, Ditte; Glerup, Simon.

    In: MethodsX, Vol. 3, 2016, p. 386-98.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    SorCS2 is required for BDNF-dependent plasticity in the hippocampus. / Glerup, S; Bolcho, U; Bøggild, S; Vaegter, C B; Smith, A H; Nieto-Gonzalez, J L; Ovesen, P L; Pedersen, L F; Fjorback, A N; Kjolby, Mads; Login, H; Holm, M M; Andersen, O M; Nyengaard, J R; Willnow, T E; Jensen, K; Nykjaer, A; Jensen, Simon Mølgaard.

    In: Molecular Psychiatry, 2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    Spatiotemporal patterns of sortilin and SorCS2 localization during organ development. / Boggild, Simon; Molgaard, Simon; Glerup, Simon; Nyengaard, Jens Randel.

    In: B M C Cell Biology, Vol. 17, 2016, p. 8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. 2015
  20. Published

    Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF. / Buttenschøn, Henriette Nørmølle; Demontis, Ditte; Ollendorff, Mathias Kaas; Elfving, Betina; Jensen, Simon Mølgaard; Gustafsen, Camilla; Kærlev, L.; Petersen, Claus Munck; Børglum, Anders; Mors, Ole; Pedersen, Simon Glerup.

    In: Translational Psychiatry, Vol. 5, No. e677, 2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. Published

    Increased sortilin in depression. / Buttenschøn, Henriette Nørmølle; Demontis, Ditte; Kaas, Mathias; Elfving, Betina; mølgaard, simon; Gustafsen, Camilla; Kærlev, Linda; Petersen, Claus Munck; Børglum, Anders; Mors, Ole; Pedersen, Simon Glerup.

    2015.

    Research output: Contribution to conferencePosterResearch

  22. 2014
  23. Published

    SorCS2 Regulates Dopaminergic Wiring and Is Processed into an Apoptotic Two-Chain Receptor in Peripheral Glia. / Glerup, Simon; Olsen, Ditte; Vægter, Christian Bjerggaard; Gustafsen, Camilla; Sjøgaard, Susanne; Hermey, Guido; Kjølby, Mads Fuglsang; Jensen, Simon Mølgaard; Ulrichsen, Maj; Hansen, Simon Bøggild; Skeldal, Sune; Fjorback, Anja Nawarecki; Nyengaard, Jens Randel; Jacobsen, Jan; Bender, Dirk; Bjarkam, Carsten R; Sørensen, Esben Skipper; Füchtbauer, Ernst-Martin; Eichele, Gregor; Madsen, Peder; Willnow, Thomas; Petersen, Claus Munck; Nykjær, Anders.

    In: Neuron, Vol. 82, No. 5, 04.06.2014, p. 1074–1087.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    The Hypercholesterolemia-Risk Gene SORT1 Facilitates PCSK9 Secretion. / Gustafsen, Camilla; Kjolby, Mads; Nyegaard, Mette; Mattheisen, Manuel; Lundhede, Jesper; Buttenschøn, Henriette; Mors, Ole; Bentzon, Jacob F; Madsen, Peder; Nykjaer, Anders; Glerup, Simon.

    In: Cell Metabolism, Vol. 19, No. 2, 10.02.2014, p. 310-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    Immunohistochemical visualization of mouse interneuron subtypes. / Jensen, Simon Mølgaard; Ulrichsen, Maj; Boggild, Simon; Holm, Marie-Louise; Vægter, Christian Bjerggaard; Nyengaard, Jens; Glerup, Simon.

    In: F1000Research, Vol. 3, 2014, p. 242.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  26. Published

    Sortilins in neurotrophic factor signaling. / Glerup, S; Nykjaer, A; Vægter, Christian Bjerggaard.

    Sortilins in neurotrophic factor signaling. Vol. 220 2014. p. 165-89.

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  27. 2013
  28. Published

    Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition. / Olsen, Ditte; Kaas, M.; Schwartz, O.; Nykjaer, A.; Glerup, S.

    In: Learning & Memory (Online), Vol. 20, No. 9, 01.09.2013, p. 499-504.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Published

    SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET. / Glerup, Simon; Lume, Maria; Olsen, Ditte; Nyengaard, Jens R; Vaegter, Christian B; Gustafsen, Camilla; Christensen, Erik I; Kjolby, Mads; Hay-Schmidt, Anders; Bender, Dirk; Madsen, Peder; Saarma, Mart; Nykjaer, Anders; Petersen, Claus M.

    In: Cell Reports, Vol. 3, 16.01.2013, p. 186-199.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  30. Published

    Formation of high-molecular-weight angiotensinogen during pregnancy is a result of competing redox reactions with the proform of eosinophil major basic protein. / Kløverpris, Søren; Skov, Louise Lind; Glerup, Simon; Pihl, Kasper; Christiansen, Michael ; Oxvig, Claus.

    In: Biochemical Journal, Vol. 449, No. 1, 01.01.2013, p. 209-217.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  31. Published

    Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein. / Gustafsen, Camilla; Glerup, Simon; Pallesen, Lone Tjener; Olsen, Ditte; Andersen, Olav M; Nykjær, Anders; Madsen, Peder; Petersen, Claus Munck.

    In: Journal of Neuroscience, Vol. 33, No. 1, 2013, p. 64-71.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. Published

    Sortilin-Related Receptor SORCS3 Is a Postsynaptic Modulator of Synaptic Depression and Fear Extinction. / Breiderhoff, Tilman; Christiansen, Gitte B; Pallesen, Lone T; Vægter, Christian Bjerggaard; Nykjaer, Anders; Holm, Mai Marie; Glerup, Simon; Willnow, Thomas E.

    In: PloS one, Vol. 8, No. 9, 2013, p. e75006.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  33. 2012
  34. Published

    SorLA regulates trafficking of Lipoprotein Lipase in polarized cells and astrocytes. / Klinger, Stine Christensen; Højland, Anne; Gustafsen, Camilla; Glerup, Simon; Kjølby, Mads Fuglsang; Helms, Hans Christian; Raarup, Merete Krog; Olivecrona, Gunilla ; Brodin, Birger; Petersen, Claus Munck; Nykjær, Anders; Nielsen, Morten Schallburg.

    2012. Poster session presented at Barriers of the CNS, New London NH, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  35. Published

    Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis. / Skeldal, Sune; Sykes, Alex M; Glerup, Simon; Matusica, Dusan; Palstra, Nickless; Autio, Henri; Boskovic, Zoran; Madsen, Peder; Castrén, Eero; Nykjaer, Anders; Coulson, Elizabeth J.

    In: Journal of Biological Chemistry, Vol. 287, No. 52, 2012, p. 43798-809.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. 2011
  37. Published

    Placental regulation of peptide hormone and growth factor activity by proMBP. / Weyer, Kathrin; Glerup, Simon.

    In: Biology of Reproduction, Vol. 84, No. 6, 01.06.2011, p. 1077-86.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  38. Published

    Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. / Vaegter, Christian B; Jansen, Pernille; Fjorback, Anja W; Glerup, Simon; Skeldal, Sune; Kjølby, Mads Fuglsang; Richner, Mette; Erdmann, Bettina; Nyengaard, Jens R; Tessarollo, Lino; Lewin, Gary R; Willnow, Thomas E; Chao, Moses V; Nykjaer, Anders.

    In: Nature Neuroscience, Vol. 14, No. 1, 01.01.2011, p. 54-61.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  39. Published

    SorLA regulates lipoprotein lipase activity by intracellular trafficking. / Klinger, Stine Christensen; Glerup, Simon; Raarup, Merete Krog; Mari, MC; Nyegaard, Mette; Koster, G; Prabakaran, Thaneas; Nilsson, SK; Kjærgaard, Maj Margrethe; Bakke, O; Nykjær, Anders; Olivecrona, G; Petersen, Claus Munck; Nielsen, MS.

    2011. Poster session presented at PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.

    Research output: Contribution to conferencePosterResearch

  40. Published

    SorLA regulates lipoprotein lipase activity by intracellular trafficking. / Klinger, Stine Christensen; Glerup, Simon; Raarup, Merete Krog; Mari, MC; Nyegaard, Mette; Koster, G; Prabakaran, Thaneas; Nilsson, SK; Kjærgaard, Maj Margrethe; Bakke, O; Nykjær, Anders; Olivecrona, G; Petersen, Claus Munck; Nielsen, MS.

    2011. Abstract from PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  41. Published

    SorLA regulates the activity of lipoprotein lipase by intracellular trafficking. / Klinger, Stine C; Glerup, Simon; Raarup, Merete K; Mari, Muriel C; Nyegaard, Mette; Koster, Gerbrand; Prabakaran, Thaneas; Nilsson, Björn Stefan; Kjaergaard, Maj M; Bakke, Oddmund; Nykjær, Anders; Olivecrona, Gunilla; Petersen, Claus Munck; Nielsen, Morten Schallburg.

    In: Journal of Cell Science, Vol. 124, No. Pt 7, 2011, p. 1095-105.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  42. 2010
  43. Published

    Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding. / Serup Andersen, Olga; Boisguerin, Prisca; Glerup, Simon; Skeldal, Sune; Volkmer, Rudolf; Willnow, Thomas E; Nykjaer, Anders; Andersen, Olav M; Glerup, Simon.

    In: The Journal of biological chemistry, Vol. 285, No. 16, 16.04.2010, p. 12210-22.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. Published

    Identification of a linear epitope in sortilin that partakes in pro-neurotropin binding. / Andersen, O.S.; Boisguerin, P.; Glerup, Simon; Skeldal, Sune; Volkmer, R.; Wilnow, T.E.; Nykjær, Anders; Andersen, Olav Michael.

    In: Journal of Biological Chemistry, 2010, p. 12210-12222.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  45. 2008
  46. Published

    Temporal course of pregnancy-associated plasma protein-A in angioplasty-treated ST-elevation myocardial infarction patients and potential significance of concomitant heparin administration. / Terkelsen, Christian J; Oxvig, Claus; Nørgaard, Bjarne L; Glerup, Simon; Poulsen, Tina S; Lassen, Jens F; Møller, Holger J; Thuesen, Leif; Falk, Erling; Nielsen, Torsten T; Andersen, Henning R.

    In: American Journal of Cardiology, Vol. 103, No. 1, 2008, p. 29-35.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  47. 2007
  48. Published

    Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor. / Glerup, Simon; Kløverpris, Søren; Laursen, Lisbeth S; Dagnaes-Hansen, Frederik; Thiel, Steffen; Conover, Cheryl A.; Oxvig, Claus.

    In: Journal of Biological Chemistry, Vol. 282, No. 3, 19.01.2007, p. 1769-1778.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  49. Published

    Inhibition of proteolysis and prohormone conversion by proMBP. / Glerup, Simon.

    2007.

    Research output: Book/anthology/dissertation/reportPh.D. thesisResearch

  50. 2006
  51. Published

    The proform of the eosinophil major basic protein binds the cell surface through a site distinct from its C-type lectin ligand-binding region. / Glerup, Simon; Kløverpris, Søren; Oxvig, Claus.

    In: Journal of Biological Chemistry, Vol. 281, No. 42, 20.10.2006, p. 31509-31516.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  52. Published

    Definition, expression, and characterization of a protein domain in the N-terminus of pregnancy-associated plasma protein-A distantly related to the family of laminin G-like modules. / Boldt, Henning Bünsow; Glerup, Simon; Overgaard, Michael Toft; Sottrup-Jensen, Lars; Oxvig, Claus.

    In: Protein Expr Purif., Vol. 48, No. 2, 2006, p. 261-73.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  53. Published

    Proform of eosinophil major basic protein binds the cell surface through a site distinct from its c-type lectin ligand-binding region. / Glerup, Simon; Kløverpris, Søren; Oxvig, Claus.

    In: Journal of Biological Chemistry, Vol. 281, 2006, p. 31509-31516.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  54. 2005
  55. Published

    Proteinase inhibition by proform of eosinophil major basic protein (pro-MBP is a multistep process of intra- and intermolecular disulfide rearrangements). / Glerup, Simon; Boldt, Henning Bünsow; Overgaard, Mikael; Sottrup-Jensen, Lars; Giudice, Linda C.; Oxvig, Claus.

    In: Journal of Biological Chemistry, Vol. 280, 2005, p. 9823-9832.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  56. 2004
  57. Published

    Inhibition of proteolysis by the proform of eosinophil major basic protein (proMBP) requires covalent binding to its target proteinase. / Overgaard, Michael Toft; Glerup, Simon; Boldt, Henning Bünsow; Rodacker, Vivien; Marie Olsen, Inger; Christiansen, Michael; Sottrup-Jensen, Lars; Giudice, Linda C.; Oxvig, Claus.

    In: F E B S Letters, Vol. 560, 2004, p. 147-152.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  58. Published

    Inhibition of proteolysis by the proform of eosinophil major basic protein (proMBP) requires covalent binding to its target proteinase. / Overgaard, M.T.; Glerup, S.; Boldt, H.B.; Olsen, I.M.; Christiansen, M.; Sottrup-Jensen, L.; Giudice, L.C.; Oxvig, C.

    In: F E B S Letters, Vol. 560, 2004, p. 147-152.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review