Leif Østergaard

  1. 2018
  2. Published

    Noninvasive assessment of isocitrate dehydrogenase mutation status in cerebral gliomas by magnetic resonance spectroscopy in a clinical setting. / Tietze, Anna; Choi, Changho; Mickey, Bruce; Maher, Elizabeth A; Parm Ulhøi, Benedicte; Sangill, Ryan; Lassen-Ramshad, Yasmin; Lukacova, Slavka; Østergaard, Leif; von Oettingen, Gorm.

    In: Journal of Neurosurgery: Spine, 01.02.2018, p. 1-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  3. Published

    Impact of age on cardiovascular function, inflammation, and oxidative stress in experimental asphyxial cardiac arrest. / Secher, N; Østergaard, L; Tønnesen, E; Hansen, F B; Granfeldt, A.

    In: Acta Anaesthesiologica Scandinavica, Vol. 62, No. 1, 2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  4. Published

    The effects of hypercapnia on cortical capillary transit time heterogeneity (CTH) in anesthetized mice. / Gutiérrez-Jiménez, Eugenio; Angleys, Hugo; Rasmussen, Peter Mondrup; Mikkelsen, Irene Klærke; Mouridsen, Kim; Østergaard, Leif.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 38, No. 2, 271678X17692598, 2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  5. Published

    Disturbances in the control of capillary flow in an aged APP(swe)/PS1 Delta E9 model of Alzheimer's disease. / Gutierrez-Jimenez, Eugenio; Angleys, Hugo; Rasmussen, Peter M.; West, Mark J.; Catalini, Laura; Iversen, Nina K.; Jensen, Morten S.; Frische, Sebastian; Ostergaard, Leif.

    In: Neurobiology of Aging, Vol. 62, 02.2018, p. 82-94.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  6. Published
  7. E-pub ahead of print

    The effect of carotid artery stenting on capillary transit time heterogeneity in patients with carotid artery stenosis. / Arsava, Ethem M; Hansen, Mikkel Bo; Kaplan, Berkan; Peker, Ahmet; Gocmen, Rahsan; Arat, Anil; Oguz, Kader K; Topcuoglu, Mehmet A; Østergaard, Leif; Dalkara, Turgay.

    In: European Stroke Journal, 26.04.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  8. Published

    Hippocampal Atrophy Following Subarachnoid Hemorrhage Correlates with Disruption of Astrocyte Morphology and Capillary Coverage by AQP4. / Anzabi, Maryam; Ardalan, Maryam; Iversen, Nina Kerting; H. Rafati, Ali; Hansen, Brian; Østergaard, Leif.

    In: Frontiers in cellular neuroscience, Vol. 12, No. 19, 2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  9. Accepted/In press

    The effects of capillary transit time heterogeneity (CTH) on the BOLD signal. / Angleys, Hugo; Jespersen, Sune; Østergaard, Leif.

    In: Human Brain Mapping, 2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  10. 2017
  11. Published

    Capillary dysfunction in the development of diabetic peripheral neuropathy in animal models. / Dudele, Anete; Gutierrez, Eugenio; Iversen, Nina Kerting; Frische, Sebastian; Staehelin-Jensen, Troels; Østergaard, Leif.

    2017. 276-276 Abstract from 2017 PNS (Peripheral Nerve Society) Annual Meeting , Barcelona, Spain.

    Research output: Contribution to conferenceConference abstract for conference

  12. Published
  13. Published

    The effect of congenital heart disease on cerebral function and comorbidity in adulthood. / Arlander, Benjamin Asschenfeldt; Heiberg, Johan; Østergaard, Leif; Ringgaard, Steffen; Hjortdal, Vibeke E.

    2017. Poster session presented at 27th Annual Meeting, Scandinavian Society for Research in Cardiothoracic Surgery, Geilo, Norway.

    Research output: Contribution to conferencePoster

  14. Published

    White Matter Biomarkers from Fast Protocols Using Axially Symmetric Diffusion Kurtosis Imaging. / Hansen, Brian; Khan, Ahmad Raza; Shemesh, Noam; Lund, Torben Ellegaard; Sangill, Ryan; Østergaard, Leif; Jespersen, Sune Nørhøj.

    Proceedings of ISMRM 25th Annual Meeting. 2017. p. 1742.

    Research output: Contribution to book/anthology/report/proceedingConference abstract in proceedings

  15. Published

    Model-based inference from microvascular measurements : Combining experimental measurements and model predictions using a Bayesian probabilistic approach. / Rasmussen, Peter M; Smith, Amy F; Sakadžić, Sava; Boas, David A; Pries, Axel R; Secomb, Timothy W; Østergaard, Leif.

    In: Microcirculation, Vol. 24, No. 4, 05.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  16. Published
  17. Published
  18. Published

    Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease. / Nielsen, Rune B; Egefjord, Lærke; Angleys, Hugo; Mouridsen, Kim; Gejl, Michael; Møller, Arne; Brock, Birgitte; Brændgaard, Hans; Gottrup, Hanne; Rungby, Jørgen; Eskildsen, Simon F; Østergaard, Leif.

    In: Alzheimer's & Dementia, Vol. 13, No. 10, 10.2017, p. 1143-1153.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  19. E-pub ahead of print

    Acute reperfusion without recanalization : Serial assessment of collaterals within 6 h of using perfusion-weighted magnetic resonance imaging. / Makris, Nikolaos; Chamard, Leila; Mikkelsen, Irene K; Hermier, Marc; Derex, Laurent; Pedraza, Salvador; Thomalla, Götz; Østergaard, Leif; Baron, Jean-Claude; Nighoghossian, Norbert; Berthezène, Yves; Cho, Tae-Hee.

    In: Journal of Cerebral Blood Flow and Metabolism, 01.01.2017, p. 271678X17744716.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  20. Published
  21. Published

    Cortical spreading depolarizations in the postresuscitation period in a cardiac arrest male rat model. / Hansen, Frederik Boe; Secher, Niels; Jensen, Morten Skovgaard; Østergaard, Leif; Tønnesen, Else Kirstine; Granfeldt, Asger.

    In: Journal of Neuroscience Research, Vol. 95, No. 10, 2017, p. 2040-2050.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  22. Published

    White matter biomarkers from fast protocols using axially symmetric diffusion kurtosis imaging. / Hansen, Brian; Khan, Ahmad R; Shemesh, Noam; Lund, Torben E; Sangill, Ryan; Eskildsen, Simon F; Østergaard, Leif; Jespersen, Sune N.

    In: NMR in Biomedicine, Vol. 30, No. 9, e3741, 09.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  23. Published

    Schwann cell interactions with axons and microvessels in diabetic neuropathy. / Gonçalves, Nádia P; Vægter, Christian B; Andersen, Henning; Østergaard, Leif; Calcutt, Nigel A; Jensen, Troels S.

    In: Nature Reviews. Neurology, Vol. 13, 30.03.2017, p. 135-147.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  24. Published

    Increased cortical capillary transit time heterogeneity in Alzheimer’s disease: a DSC-MRI perfusion study. / Eskildsen, Simon F.; Gyldensted, Louise; Nagenthiraja, Kartheeban; Nielsen, Rune B.; Hansen, Mikkel Bo; Dalby, Rikke B.; Frandsen, Jesper; Rodell, Anders; Gyldensted, Carsten; Jespersen, Sune Nørhøj; Lund, Torben E.; Mouridsen, Kim; Brændgaard, Hans; Østergaard, Leif.

    In: Neurobiology of Aging, Vol. 50, 2017, p. 107-118.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  25. E-pub ahead of print

    Transit time homogenization in ischemic stroke - A novel biomarker of penumbral microvascular failure? / Engedal, Thorbjørn S; Hjort, Niels; Hougaard, Kristina D; Simonsen, Claus Z; Andersen, Grethe; Mikkelsen, Irene Klærke; Boldsen, Jens K; Eskildsen, Simon F; Hansen, Mikkel B; Angleys, Hugo; Jespersen, Sune N; Pedraza, Salvador; Cho, Tae-Hee; Serena, Joaquín; Siemonsen, Susanne; Thomalla, Götz; Nighoghossian, Norbert; Fiehler, Jens; Mouridsen, Kim; Østergaard, Leif.

    In: Journal of Cerebral Blood Flow and Metabolism, 31.07.2017, p. 271678X17721666.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  26. 2016
  27. Published

    Disruption of microvascular flow-patterns in Alzheimer's disease correlates with neurodegeneration and cognitive decline. / Nielsen, Rune Bæksager; Egefjord, Lærke; Eskildsen, Simon Fristed; Møller, Arne; Brændgaard, Hans; Jensen, Michael Gejl; Brock, Birgitte; Rungby, Jørgen; Østergaard, Leif.

    2016. Abstract from 10th FENS Forum of Neuroscience 2016, .

    Research output: Contribution to conferenceConference abstract for conference

  28. Published

    Capillary dysfunction in Alzheimer’s disease correlates with cognitive decline. / Eskildsen, Simon Fristed; Gyldensted, Louise; Nagenthiraja, Kartheeban; Hansen, Mikkel Bo; Dalby, Rikke Beese; Frandsen, Jesper; Rodell, Anders; Gyldensted, Carsten; Jespersen, Sune Nørhøj; Mouridsen, Kim; Brændgaard, Hans; Østergaard, Leif.

    2016. Abstract from 10th FENS FORUM of Neuroscience 2016, København, Denmark.

    Research output: Contribution to conferenceConference abstract for conference

  29. Published

    Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline. / Østergaard, Leif; Engedal, Thorbjørn Søndergaard; Moreton, Fiona ; Hansen, Mikkel Bo; Wardlaw, Joanna M.; Dalkara, Turgay; Markus, Hugh S; Muir, Keith W.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 36, No. 2, 01.02.2016, p. 302-25.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  30. Accepted/In press

    Non-invasive assessment of Isocitrate dehydrogenase (IDH) mutational status in cerebral gliomas by Magnetic Resonance Spectroscopy in a clinical setting. / Tietze, Anna; Choi, Changho; Mickey, Bruce; Maher, Elizabeth; Ulhøi, Benedicte Parm; Sangill, Ryan; Lassen, Yasmin Alexandra; Lukácová, Slávka; Østergaard, Leif; Oettingen, Gorm von.

    In: Journal of Neurosurgery, 13.10.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  31. Published

    Comparing anesthesia with isoflurane and fentanyl/fluanisone/midazolam in a rat model of cardiac arrest. / Secher, Niels; Malte, Christian Lind; Tønnesen, Else; Østergaard, Leif; Granfeldt, Asger.

    In: Journal of Applied Physiology, 2016, p. jap.00998.2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  32. Published

    Sequential MR Assessment of the Susceptibility Vessel Sign and Arterial Occlusion in Acute Stroke. / Ritzenthaler, Thomas; Lacalm, Audrey; Cho, Tae-Hee; Maucort-Boulch, Delphine; Klaerke Mikkelsen, Irene; Ribe, Lars; Østergaard, Leif; Hjort, Niels; Fiehler, Jens; Pedraza, Salvador; Louis Tisserand, Guy; Baron, Jean-Claude; Berthezene, Yves; Nighoghossian, Norbert.

    In: Journal of Neuroimaging, Vol. 26, No. 3, 2016, p. 355-359.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  33. Published

    Capillary Transit Time Heterogeneity Is Associated with Modified Rankin Scale Score at Discharge in Patients with Bilateral High Grade Internal Carotid Artery Stenosis. / Mundiyanapurath, Sibu; Ringleb, Peter Arthur; Diatschuk, Sascha; Hansen, Mikkel Bo; Mouridsen, Kim; Østergaard, Leif; Wick, Wolfgang; Bendszus, Martin; Radbruch, Alexander.

    In: PloS one, Vol. 11, No. 6, 2016, p. e0158148.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  34. Published

    Reduced cerebral cortical thickness in Non-cirrhotic patients with hepatitis C. / Hjerrild, Simon; Renvillard, Signe Groth; Leutscher, Peter; Sørensen, Leif Hougaard; Østergaard, Leif; Eskildsen, Simon Fristed; Videbech, Poul.

    In: Metabolic Brain Disease, Vol. 31, No. 2, 2016, p. 311-319.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  35. Published

    Automated Estimation of Salvageable Tissue : Comparison with Expert Readers. / Hansen, Mikkel Bo; Nagenthiraja, Kartheeban; Ribe, Lars Riisgaard; Hougaard, Kristina Dupont; Østergaard, Leif; Mouridsen, Kim.

    In: Journal of Magnetic Resonance Imaging, Vol. 43, No. 1, 01.2016, p. 220-228.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  36. E-pub ahead of print

    Reliable estimation of microvascular flow patterns in patients with disrupted blood–brain barrier using dynamic susceptibility contrast MRI. / Hansen, Mikkel Bo; Tietze, Anna; kalpathy-Cramer, jayashree; Gerstner, Elizabeth; Batchelor, Tracy T.; Østergaard, Leif; Mouridsen, Kim.

    In: Journal of Magnetic Resonance Imaging, 30.11.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  37. Published

    White matter biomarkers from fast protocols using axially symmetric diffusion kurtosis imaging. / Hansen, Brian; Khan, Ahmad R.; Shemesh, Noam; Lund, Torben E.; Sangill, Ryan; Østergaard, Leif; Jespersen, Sune N.

    In: arXiv preprint, 10.10.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  38. Published

    Effect of electrical forepaw stimulation on capillary transit-time heterogeneity (CTH). / Gutiérrez-Jiménez, Eugenio; Cai, Changsi; Mikkelsen, Irene Klærke; Rasmussen, Peter Mondrup; Angleys, Hugo; Merrild, Mads; Mouridsen, Kim; Jespersen, Sune Nørhøj; Lee, Jonghwan; Iversen, Nina Kerting; Sakadzic, Sava; Østergaard, Leif.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 36, No. 12, 01.12.2016, p. 2072-2086.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  39. Published

    Does b1000-b0 Mismatch Challenge Diffusion-Weighted Imaging-Fluid Attenuated Inversion Recovery Mismatch in Stroke? / Geraldo, Ana Filipa; Berner, Lise-Prune; Haesebaert, Julie; Chabrol, Aurélie; Cho, Tae-Hee; Derex, Laurent; Hermier, Marc; Louis-Tisserand, Guy; Chamard, Leila; Klaerke Mikkelsen, Irene; Ribe, Lars; Østergaard, Leif; Hjort, Niels; Pedraza, Salvador; Thomalla, Götz; Baron, Jean-Claude; Nighoghossian, Norbert; Berthèzene, Yves.

    In: Stroke; a journal of cerebral circulation, 03.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  40. E-pub ahead of print

    Assessment of tumor oxygenation and its impact on treatment response in bevacizumab-treated recurrent glioblastoma. / Bonekamp, David; Mouridsen, Kim; Radbruch, Alexander; Kurz, Felix T; Eidel, Oliver; Wick, Antje; Schlemmer, Heinz-Peter; Wick, Wolfgang; Bendszus, Martin; Østergaard, Leif; Kickingereder, Philipp.

    In: Journal of Cerebral Blood Flow and Metabolism, 09.02.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  41. Published

    Perfusion and pH MRI in familial hemiplegic migraine with prolonged aura. / Blicher, Jakob Udby; Tietze, Anna; Donahue, Manus J; Smith, Seth A; Østergaard, Leif.

    In: Cephalalgia, Vol. 36, No. 3, 01.03.2016, p. 279-83.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  42. Published

    MRI Assessment of Ischemic Lesion Evolution within White and Gray Matter. / Berner, Lise-Prune; Cho, Tae-Hee; Haesebaert, Julie; Bouvier, Julien; Wiart, Marlène; Hjort, Niels; Klærke Mikkelsen, Irene; Derex, Laurent; Thomalla, Götz; Pedraza, Salvador; Østergaard, Leif; Baron, Jean-Claude; Nighoghossian, Norbert; Berthezène, Yves.

    In: Cerebrovascular Diseases, Vol. 41, No. 5-6, 12.02.2016, p. 291-297.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  43. Published

    The effects of capillary transit time heterogeneity (CTH) on the cerebral uptake of glucose and glucose analogs: Application to FDG and comparison to oxygen uptake. / Angleys, Hugo; Jespersen, Sune; Østergaard, Leif.

    In: Frontiers in Computational Neuroscience, Vol. 10, 103, 15.09.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  44. 2015
  45. Published

    Cortical capillary dysfunction in patients suspected of Alzheimer’s disease. / Eskildsen, Simon Fristed; Gyldensted, Louise; Nagenthiraja, Kartheeban; Hansen, Mikkel Bo; Dalby, Rikke Beese; Frandsen, Jesper; Rodell, Anders; Gyldensted, Carsten; Jespersen, Sune Nørhøj; Mouridsen, Kim; Brændgaard, Hans; Østergaard, Leif.

    2015. Abstract from The Alzheimer's Association International Conference 2015, Washington D.C., United States.

    Research output: Contribution to conferenceConference abstract for conference

  46. Published

    The Impact of Age on Coronary Perfusion, Cardiac Function and Inflammation in a Rat Model of Ashpyxial Cardiac Arrest. / Secher, Niels; Østergaard, Leif; Tønnesen, Else Kirstine; Granfeldt, Asger.

    2015. Poster session presented at American Heart Association Scientific Sessions 2015, Orlando, Florida, Denmark.

    Research output: Contribution to conferencePoster

  47. Published

    Cortical Spreading Depolarizations after Cardiac Arrest in an Asphyxial Rat Model. / Hansen, Frederik Boe; Secher, Niels; Jensen, Morten Skovgaard; Østergaard, Leif; Tønnesen, Else Kirstine; Granfeldt, Asger.

    2015. Poster session presented at American Heart Association Scientific Sessions, Orlando, United States.

    Research output: Contribution to conferencePoster

  48. Published

    Hjernen. / Østergaard, Leif.

    Aarhus : Aarhus Universitetsforlag, 2015. 59 p.

    Research output: Book/anthology/dissertation/reportBook

  49. Published

    Capillary dysfunction: Its detection and causative role in dementias and stroke. / Østergaard, Leif; Jespersen, Sune Nørhøj; Engedal, Thorbjørn Søndergaard; Jiménez, Eugenio Gutiérrez; Ashkanian, Mahmoud; Hansen, Mikkel Bo; Eskildsen, Simon; Mouridsen, Kim.

    In: Current Neurology and Neuroscience Reports, Vol. 15, No. 6, 06.2015, p. 37.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  50. Published

    Microcirculatory dysfunction and tissue oxygenation in critical illness. / Østergaard, Leif; Granfeldt, A; Secher, N; Tietze, A; Iversen, N K; Jensen, Morten Skovgaard; Andersen, Kristian Kjær; Nagenthiraja, K; Gutiérrez-Lizardi, P; Mouridsen, K; Jespersen, S N; Tønnesen, E K.

    In: Acta Anaesthesiologica Scandinavica, Vol. 59, No. 10, 01.11.2015, p. 1246-59.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  51. Published

    Neurovascular coupling during cortical spreading depolarization and -depression. / Østergaard, Leif; Dreier, Jens Peter; Hadjikhani, Nouchine; Jespersen, Sune Nørhøj; Dirnagl, Ulrich; Dalkara, Turgay.

    In: Stroke; a journal of cerebral circulation, Vol. 46, No. 5, 05.2015, p. 1392-401.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  52. Published

    The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy. / Østergaard, Leif; Finnerup, Nanna B.; Terkelsen, Astrid J.; Olesen, Rasmus A.; Drasbek, Kim R.; Knudsen, Lone; Jespersen, Sune N.; Frystyk, Jan; Charles, Morten; Thomsen, Reimar W.; Christiansen, Jens S.; Beck-Nielsen, Henning; Jensen, Troels S.; Andersen, Henning.

    In: Diabetologia, Vol. 58, No. 4, 2015, p. 666-677.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  53. Published

    Mean Diffusional Kurtosis in Patients with Glioma : Initial Results with a Fast Imaging Method in a Clinical Setting. / Tietze, A.; Hansen, Mikkel Bo; Østergaard, Leif; Jespersen, S. N.; Sangill, R.; Lund, T. E.; Geneser, M.; Hjelm, Mette; Hansen, Brian.

    In: American Journal of Neuroradiology, Vol. 36, No. 8, 08.2015, p. 1472-1478.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  54. Published

    Perfusion MRI derived indices of microvascular shunting and flow control correlate with tumor grade and outcome in patients with cerebral glioma. / Tietze, Anna; Mouridsen, Kim; Lassen-Ramshad, Yasmin; Østergaard, Leif.

    In: P L o S One, Vol. 10, No. 4, 2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  55. Published
  56. Published

    Preserved cerebral microcirculation after cardiac arrest in a rat model. / Secher, Niels; Østergaard, Leif; Iversen, Nina K; Lambertsen, Kate L; Clausen, Bettina H; Tønnesen, Else; Granfeldt, Asger.

    In: Microcirculation (New York, N.Y. : 1994), Vol. 66, No. 6, 01.08.2015, p. 464-74.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  57. Published

    The effects of transit time heterogeneity on brain oxygenation during rest and functional activation. / Rasmussen, Peter Mondrup; Jespersen, Sune N; Ostergaard, Leif.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 35, No. 3, 2015, p. 432-42.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  58. Published

    Evaluation of Early Reperfusion Criteria in Acute Ischemic Stroke. / Ozenne, Brice; Cho, Tae-Hee; Mikkelsen, Irene Klaerke; Hermier, Marc; Ribe, Lars; Thomalla, Götz; Pedraza, Salvador; Baron, Jean-Claude; Roy, Pascal; Berthezène, Yves; Nighoghossian, Norbert; Østergaard, Leif; Maucort-Boulch, Delphine.

    In: Journal of Neuroimaging, Vol. 25, No. 6, 01.11.2015, p. 951-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  59. Published

    Spatially regularized mixture model for lesion segmentation with application to stroke patients. / Ozenne, Brice; Subtil, Fabien; Østergaard, Leif; Maucort-Boulch, Delphine.

    In: Biostatistics, Vol. 16, No. 3, 01.07.2015, p. 580-95.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  60. Published

    Biased visualization of hypoperfused tissue by computed tomography due to short imaging duration : improved classification by image down-sampling and vascular models. / Mikkelsen, Irene Klærke; Jones, P Simon; Ribe, Lars Riisgaard; Alawneh, Josef; Puig, Josep; Bekke, Susanne Lise; Tietze, Anna; Gillard, Jonathan H; Warburton, Elisabeth A; Pedraza, Salva; Baron, Jean-Claude; Østergaard, Leif; Mouridsen, Kim.

    In: European Radiology, Vol. 25, No. 7, 01.07.2015, p. 2080-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  61. Published

    Making sense: Dopamine activates conscious self-monitoring through medial prefrontal cortex. / Joensson, Morten; Rømer Thomsen, Kristine; Andersen, Lau M.; Gross, Joachim; Mouridsen, Kim; Sandberg, Kristian; Østergaard, Leif; Lou, Hans Olav Christensen.

    In: Human Brain Mapping, Vol. 36, No. 5, 2015, p. 1866-77.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  62. Published

    Early Blood Brain Barrier Changes in Acute Ischemic Stroke : A Sequential MRI Study. / Giraud, Marc; Cho, Tae-Hee; Nighoghossian, Norbert; Maucort-Boulch, Delphine; Deiana, Gianluca; Østergaard, Leif; Baron, Jean-Claude; Fiehler, Jens; Pedraza, Salvador; Derex, Laurent; Berthezène, Yves.

    In: Journal of Neuroimaging, Vol. 25, No. 6, 02.12.2015, p. 959-63.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  63. Published

    Validity of shape as a predictive biomarker of final infarct volume in acute ischemic stroke. / Frindel, Carole; Rouanet, Anaïs; Giacalone, Mathilde; Cho, Tae-Hee; Østergaard, Leif; Fiehler, Jens; Pedraza, Salvador; Baron, Jean-Claude; Wiart, Marlène; Berthezène, Yves; Nighoghossian, Norbert; Rousseau, David.

    In: Stroke; a journal of cerebral circulation, Vol. 46, No. 4, 04.2015, p. 976-81.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  64. Published

    Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome. / Cho, Tae-Hee; Nighoghossian, Norbert; Mikkelsen, Irene Klærke; Derex, Laurent; Hermier, Marc; Pedraza, Salvador; Fiehler, Jens; Østergaard, Leif; Berthezène, Yves; Baron, Jean-Claude.

    In: Stroke; a journal of cerebral circulation, Vol. 46, No. 6, 06.2015, p. 1582-1589.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  65. Published

    GABA Levels Are Decreased After Stroke and GABA Changes During Rehabilitation Correlate With Motor Improvement. / Blicher, Jakob; Near, Jamie; Næss-Schmidt, Erhard; Stagg, Charlotte J; Johansen-Berg, Heidi; Nielsen, Jørgen Feldbæk; Østergaard, Leif; Ho, Yi Ching Lynn.

    In: Neurorehabilitation and Neural Repair, Vol. 29, No. 3, 2015, p. 278-86.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  66. Published

    The effects of capillary transit time heterogeneity (CTH) on brain oxygenation. / Angleys, Hugo; Østergaard, Leif; Jespersen, Sune N.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 35, No. 5, 05.2015, p. 806-17.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  67. 2014
  68. Published

    Preserved Cerebral Microcirculation After Cardiac Arrest in an Asphyxial Rat Model. / Secher, Niels; Hansen, Frederik Boe; Tønnesen, Else Kirstine; Østergaard, Leif; Granfeldt, Asger.

    2014. Abstract from Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association Location, Chicago, United States.

    Research output: Contribution to conferenceConference abstract for conference

  69. Published

    Capillary transit time heterogeneity in the cerebrum correlate with cognitive decline in AD. / Eskildsen, Simon Fristed; Gyldensted, Louise; Nagenthiraja, Kartheeban; Hansen, Mikkel; Dalby, Rikke; Frandsen, Jesper; Rodell, Anders; Gyldensted, Carsten; Jespersen, Sune Nørhøj; Mouridsen, Kim; Brændgaard, Hans; Østergaard, Leif.

    2014.

    Research output: Contribution to conferenceConference abstract for conference

  70. Published

    Preserved Cerebral Microcirculation after Cardiac Arrest in an Asphyxial Rat Model. / Secher, Niels; Hansen, Frederik Boe; Tønnesen, Else Kirstine; Østergaard, Leif; Granfeldt, Asger.

    2014. Poster session presented at American Heart Association 2014, Chicago, United States.

    Research output: Contribution to conferencePoster

  71. Published

    Biomarkers in the brain after mTBI: A multimodal MRI study. / Næss-Schmidt, Erhard; Blicher, Jakob; Tietze, Anna; Eskildsen, Simon Fristed; Hansen, Brian; Lund, Torben Ellegaard; Østergaard, Leif; Nielsen, Jørgen Feldbæk.

    2014. Poster session presented at 8th World Congress for NeuroRehabilitation, Istanbul, Turkey.

    Research output: Contribution to conferencePoster

  72. Published

    Neuroplasticity in Constraint-Induced Movement Therapy. / Blicher, Jakob; Near, Jamie; Næss-Schmidt, Erhard; Østergaard, Leif; Johansen-Berg, Heidi; Stagg, Charlotte; Nielsen, Jørgen Feldbæk; Ho, Yi Ching Lynn.

    Replace, Repair, Restore, Relieve: Bridging Clinical and Engineering Solutions in Neurorehabilitation. ed. / Winnie Jensen; Ole Kæseler Andersen; Metin Akay. Vol. 7 Springer, 2014. p. 23-24.

    Research output: Contribution to book/anthology/report/proceedingArticle in proceedings

  73. Published
  74. Published
  75. Published

    The role of capillary transit time heterogeneity in myocardial oxygenation and ischemic heart disease. / Østergaard, Leif; Kristiansen, Steen Buus; Angleys, Hugo; Frøkiær, Jørgen; Michael Hasenkam, J; Jespersen, Sune Nørhøj; Bøtker, Hans Erik.

    In: Basic Research in Cardiology, Vol. 109, No. 3, 409, 18.04.2014.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  76. Published

    Assessment of ischemic penumbra in patients with hyperacute stroke using amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI. / Tietze, Anna; Blicher, Jakob; Mikkelsen, Irene Klærke; Østergaard, Leif; Strother, Megan K; Smith, Seth A; Donahue, Manus J.

    In: N M R in Biomedicine (Online), Vol. 27, No. 2, 02.2014, p. 163-174.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  77. Published

    A multicenter, randomized, double-blind, placebo-controlled trial to test efficacy and safety of magnetic resonance imaging-based thrombolysis in wake-up stroke (WAKE-UP). / Thomalla, Götz; Fiebach, Jochen B; Østergaard, Leif; Pedraza, Salvador; Thijs, Vincent; Nighoghossian, Norbert; Roy, Pascal; Muir, Keith W; Ebinger, Martin; Cheng, Bastian; Galinovic, Ivana; Cho, Tae-Hee; Puig, Josep; Boutitie, Florent; Simonsen, Claus Z; Endres, Matthias; Fiehler, Jens; Gerloff, Christian; WAKE-UP investigators.

    In: International Journal of Stroke, Vol. 9, No. 6, 08.2014, p. 829-36.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  78. Published

    Reliable estimation of capillary transit time distributions using DSC-MRI. / Mouridsen, Kim; Hansen, Mikkel Bo; Østergaard, Leif; Jespersen, Sune Nørhøj.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 34, No. 9, 2014, p. 1511-21.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  79. Published

    Blood pressure reduction does not reduce perihematoma oxygenation : a CT perfusion study. / Kate, Mahesh P; Hansen, Mikkel B; Mouridsen, Kim; Østergaard, Leif; Choi, Victor; Gould, Bronwen E; McCourt, Rebecca; Hill, Michael D; Demchuk, Andrew M; Coutts, Shelagh B; Dowlatshahi, Dariush; Emery, Derek J; Buck, Brian H; Butcher, Kenneth S.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 34, No. 1, 03.01.2014, p. 81-86.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  80. Published

    Perfusion Magnetic Resonance Imaging : A Comprehensive Update on Principles and Technique. / Jahng, Geon-Ho; Li, Ka-Loh; Østergaard, Leif; Calamante, Fernando.

    In: Korean Journal of Radiology, Vol. 15, No. 5, 15.07.2014, p. 554-577.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  81. Published

    Remote Ischemic Perconditioning as an Adjunct Therapy to Thrombolysis in Patients With Acute Ischemic Stroke : A Randomized Trial. / Hougaard, Kristina Dupont; Hjort, Niels; Zeidler, Dora; Sørensen, Leif; Nørgaard, Anne; Hansen, Troels Martin; Weitzel, Paul von; Simonsen, Claus Z; Damgaard, Dorte Winther; Gottrup, Hanne; Svendsen, Kristina; Rasmussen, Peter Vestergaard; Ribe, Lars R; Mikkelsen, Irene K; Nagenthiraja, Kartheeban; Cho, Tae-Hee; Redington, Andrew N; Bøtker, Hans Erik; Østergaard, Leif; Mouridsen, Kim; Andersen, Grethe.

    In: Stroke; a journal of cerebral circulation, Vol. 45, No. 1, 03.01.2014, p. 159-67.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  82. Published

    Influence of stroke infarct location on functional outcome measured by the modified rankin scale. / Cheng, Bastian; Forkert, Nils Daniel; Zavaglia, Melissa; Hilgetag, Claus C; Golsari, Amir; Siemonsen, Susanne; Fiehler, Jens; Pedraza, Salvador; Puig, Josep; Cho, Tae-Hee; Alawneh, Josef; Baron, Jean-Claude; Østergaard, Leif; Gerloff, Christian; Thomalla, Götz.

    In: Stroke; a journal of cerebral circulation, Vol. 45, No. 6, 06.2014, p. 1695-702.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  83. 2013
  84. Published

    Increased cerebral oxygen extraction capacity in patients with Alzheimer’s disease. / Eskildsen, Simon Fristed; Gyldensted, Louise; Nagenthiraja, Kartheeban; Frandsen, Jesper; Rodell, Anders; Gyldensted, Carsten; Jespersen, Sune Nørhøj; Mouridsen, Kim; Brændgaard, Hans; Østergaard, Leif.

    2013. Abstract from Alzheimer's Association International Conference, Boston, United States.

    Research output: Contribution to conferenceConference abstract for conference

  85. Published

    Application of Chemical Exchange Saturation Transfer (CEST) MRI in Acute Human Stroke Patients Demonstrates New Potential for Visualization of Tissue Acidosis and Infarction Risk. / Donahue, Manus; Tietze, Anna; Mikkelsen, Irene Klærke; Østergaard, Leif; Strother, Megan; Smith, Seth; Blicher, Jakob.

    2013. Abstract from ISMRM 2013, Salt Lake City, United States.

    Research output: Contribution to conferenceConference abstract for conference

  86. Published

    Application of Chemical Exchange Saturation Transfer (CEST) MRI in Acute Stroke to Visualize Tissue Acidosis and Infarction Risk. / Blicher, Jakob; Tietze, Anna; Mikkelsen, Irene Klærke; Østergaard, Leif; Strother, Megan; Smith, Seth; Donahue, Manus.

    2013. Abstract from World Congress of Neurology, Vienna, Austria.

    Research output: Contribution to conferenceConference abstract for conference

  87. Published

    Intracortical GABA is decreased after stroke and further suppressed with successful rehabilitation. / Blicher, Jakob; Near, Jamie; Næss-Schmidt, Erhard; Østergaard, Leif; Johansen-Berg, Heidi; Ho, Yi-Ching Lynn.

    2013. Abstract from World Congress of Neurology, Vienna, Austria.

    Research output: Contribution to conferenceConference abstract for conference

  88. Published

    Capillary Dysfunction in Alzheimer's Disease. / Østergaard, Leif; Nagenthiraja, Kartheeban; Gyldensted, Louise; Rodell, Anders; Gyldensted, Carsten; Jespersen, Sune Nørhøj; Mouridsen, Kim; Brændgaard, Hans; West, Mark J.

    2013. Poster session presented at Alzheimer's Association International Conference, Boston, United States.

    Research output: Contribution to conferencePoster

  89. Published

    Vigtige metoder til undersøgelse af hjernen. / Hansen, Brian; Østergaard, Leif.

    Hjernen - fra celle til samfund. ed. / Henriette Blæsild Vuust. 2013. p. 164-167.

    Research output: Contribution to book/anthology/report/proceedingBook chapter

  90. Published
  91. Published

    The capillary dysfunction hypothesis of Alzheimer's disease. / Østergaard, Leif; Aamand, Rasmus; Gutiérrez Jiménez, Eugenio ; Ho, Yi Ching Lynn; Blicher, Jakob; Madsen, Søren Møller; Nagenthiraja, Kartheeban; Dalby, Rikke Beese; Drasbek, Kim Ryun; Møller, Arne; Brændgaard, Hans; Mouridsen, Kim; Jespersen, Sune Nørhøj; Jensen, Morten Skovgaard; West, Mark J.

    In: Neurobiology of Aging, Vol. 34, No. 4, 12.01.2013, p. 1018-31.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  92. Published

    The relationship between tumor blood flow, angiogenesis, tumor hypoxia, and aerobic glycolysis. / Østergaard, Leif; Tietze, Anna; Nielsen, Thomas; Drasbek, Kim R; Mouridsen, Kim; Jespersen, Sune N; Horsman, Michael R.

    In: Cancer Research, Vol. 73, No. 18, 13.06.2013, p. 5618-5624.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  93. Published

    The role of the cerebral capillaries in acute ischemic stroke: the extended penumbra model. / Østergaard, Leif; Jespersen, Sune Nørhøj; Mouridsen, Kim; Mikkelsen, Irene Klærke; Jónsdóttir, Kristjana Ýr; Tietze, Anna; Blicher, Jakob; Aamand, Rasmus; Hjort, Niels; Iversen, Nina Kerting; Cai, Changsi; Hougaard, Kristina Dupont; Simonsen, Claus Ziegler; Weitzel-Mudersbach, Paul von; Modrau, Boris; Nagenthiraja, Kartheeban; Ribe, Lars Riisgaard; Hansen, Mikkel Bo; Bekke, Susanne Lise; Dahlmann, Martin Gervais; Puig, Josep; Pedraza, Salvador; Serena, Joaquín; Cho, Tae-Hee; Siemonsen, Susanne; Thomalla, Götz; Fiehler, Jens; Nighoghossian, Norbert; Andersen, Grethe.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 33, No. 5, 27.02.2013, p. 635.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  94. Published
  95. Published

    Acute Stroke Imaging Research Roadmap II. / Wintermark, Max; Albers, Gregory W; Broderick, Joseph P; Demchuk, Andrew M; Fiebach, Jochen B; Fiehler, Jens; Grotta, James C; Houser, Gary; Jovin, Tudor G; Lees, Kennedy R; Lev, Michael H; Liebeskind, David S; Luby, Marie; Muir, Keith W; Parsons, Mark W; von Kummer, Rüdiger; Wardlaw, Joanna M; Wu, Ona; Yoo, Albert J; Alexandrov, Andrei V; Alger, Jeffry R; Aviv, Richard I; Bammer, Roland; Baron, Jean-Claude; Calamante, Fernando; Campbell, Bruce C V; Carpenter, Trevor C; Christensen, Søren; Copen, William A; Derdeyn, Colin P; Haley, E Clarke; Khatri, Pooja; Kudo, Kohsuke; Lansberg, Maarten G; Latour, Lawrence L; Lee, Ting-Yim; Leigh, Richard; Lin, Weili; Lyden, Patrick; Mair, Grant; Menon, Bijoy K; Michel, Patrik; Mikulik, Robert; Nogueira, Raul G; Østergaard, Leif; Pedraza, Salvador; Riedel, Christian H; Rowley, Howard A; Sanelli, Pina C; Sasaki, Makoto; For the Stroke Imaging Research (STIR) and Virtual International Stroke Trials Archive (VISTA)-Imaging Investigators.

    In: Stroke; a journal of cerebral circulation, Vol. 44, No. 9, 16.07.2013, p. 2628-39.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  96. Published

    Dose optimization for using the contrast agent gadofosveset in magnetic resonance imaging (MRI) of domestic pig brain. / Poulsen, Erik Søndergaard; Alstrup, Aage Kristian Olsen; Zeidler, Dora; Hjort, Niels; Østergaard, Leif.

    In: Scandinavian Journal of Laboratory Animal Science, Vol. 4, 2013, p. 1-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  97. Published

    Ultra-high field (1)H magnetic resonance imaging approaches for acute hypoxia. / Nielsen, Thomas; Nielsen, Niels Christian; Holm, Thomas Hellesøe; Ostergaard, Leif; Horsman, Michael R; Busk, Morten.

    In: Acta oncologica (Stockholm, Sweden), Vol. 52, No. 7, 30.08.2013, p. 1287-1292.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  98. Published

    Automated decision-support system for prediction of treatment responders in acute ischemic stroke. / Nagenthiraja, Kartheeban; Walcott, B. P. ; Hansen, Mikkel Bo; Østergaard, Leif; Mouridsen, Kim.

    In: Frontiers in Neurology, Vol. 4, 140, 2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  99. Published

    Acute Stroke : Automatic Perfusion Lesion Outlining Using Level Sets. / Mouridsen, Kim; Nagenthiraja, Kartheeban; Jónsdóttir, Kristjana Yr; Ribe, Lars R; Neumann, Anders B; Hjort, Niels; Østergaard, Leif.

    In: Radiology, Vol. 269, No. 2, 17.05.2013, p. 404-12.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  100. Published

    Accuracy and reliability assessment of CT and MR perfusion analysis software using a digital phantom. / Kudo, Kohsuke; Christensen, Søren; Sasaki, Makoto; Østergaard, Leif; Shirato, Hiroki; Ogasawara, Kuniaki; Wintermark, Max; Warach, Steven; Stroke Imaging Repository (STIR) Investigators.

    In: Radiology, Vol. 267, No. 1, 04.2013, p. 201-11.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  101. Published

    Remote ischemic perconditioning in thrombolysed stroke patients : Randomized study of activating endogenous neuroprotection - design and MRI measurements. / Hougaard, K D; Hjort, N; Zeidler, D; Sørensen, L; Nørgaard, A; Thomsen, R B; Jonsdottir, K; Mouridsen, K; Hansen, T M; Cho, T-H; Nielsen, T T; Bøtker, H E; Østergaard, Leif; Andersen, Grethe.

    In: International Journal of Stroke, Vol. 8, No. 2, 2013, p. 141-6.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  102. Published

    Very Low Cerebral Blood Volume Predicts Parenchymal Hematoma in Acute Ischemic Stroke. / Hermitte, Laure; Cho, Tae-Hee; Ozenne, Brice; Nighoghossian, Norbert; Mikkelsen, Irene Klærke; Ribe, Lars; Baron, Jean-Claude; Østergaard, Leif; Derex, Laurent; Hjort, Niels; Fiehler, Jens; Pedraza, Salvador; Hermier, Marc; Maucort-Boulch, Delphine; Berthezène, Yves.

    In: Stroke; a journal of cerebral circulation, Vol. 44, No. 8, 08.2013, p. 2318-2320.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal article

  103. 2012
  104. Submitted
  105. Published

    A Fully Automated Penumbra Segmentation Tool. / Nagenthiraja, Kartheeban; Ribe, Lars Riisgaard; Hougaard, Kristina Dupont; Østergaard, Leif; Mouridsen, Kim.

    2012.

    Research output: Contribution to conferenceConference abstract for conference

  106. Published

    Fully automated DWI-PWI mismatch quantification in acute stroke. / Nagenthiraja, Kartheeban; Ribe, Lars Riisgaard; Hougaard, Kristina Dupont; Østergaard, Leif; Mouridsen, Kim.

    2012. Abstract from International Society of Magnetic Resonance in Medicine 2012 , Melbourne, Australia.

    Research output: Contribution to conferenceConference abstract for conference

  107. Published

    Dynamic susceptibility Contrast MRI: Compromising Perfusion Accuracy for a Better Discrimination of Hypoperfused Tissue. / Kjølby, Birgitte Fuglsang; Christensen, Søren; Mikkelsen, Irene Klærke; Mouridsen, Kim; Gall, Peter; Kiselev, Valerij; Østergaard, Leif.

    2012.

    Research output: Contribution to conferenceConference abstract for conference

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