Asger Hobolth

  1. 2017
  2. E-pub ahead of print
  3. Published

    Significance evaluation in factor graphs. / Madsen, Tobias; Hobolth, Asger; Jensen, Jens Ledet; Pedersen, Jakob Skou.

    In: BMC Bioinformatics , Vol. 18, 31.03.2017, p. 199.

    Publication: Research - peer-reviewJournal article

  4. Published
  5. 2016
  6. Published

    Hvem er bedst? : metoder til rangering i sport og videnskab. / Hobolth, Asger.

    In: Aktuel Naturvidenskab, Vol. 5, 2016, p. 26-29.

    Publication: CommunicationJournal article

  7. Published

    Inferring Population Genetic Parameters: Particle Filtering, HMM, Ripley’s K-Function or Runs of Homozygosity? / Nielsen, Svend; Simonsen, Simon ; Hobolth, Asger.

    WABI 2016: 16th International Workshop. ed. / Martin Frith; Christian Nørgaard Storm Pedersen. Vol. 9838 Springer, 2016. p. 234-245 (Lecture Notes in Computer Science).

    Publication: Research - peer-reviewArticle in proceedings

  8. Published
  9. Published
  10. Published

    The multivariate Wright–Fisher process with mutation: Moment-based analysis and inference using a hierarchical Beta model. / Hobolth, Asger; Siren, Jukka.

    In: Theoretical Population Biology, Vol. 108, 2016, p. 36-50.

    Publication: Research - peer-reviewJournal article

  11. 2015
  12. Published

    Inference Under a Wright-Fisher Model Using an Accurate Beta Approximation. / Tataru, Paula; Bataillon, Thomas; Hobolth, Asger.

    In: Genetics, Vol. 201, No. 3, 11.2015, p. 1133-1141.

    Publication: Research - peer-reviewJournal article

  13. Published

    Extreme selective sweeps independently targeted the X chromosomes of the great apes. / Nam, Kiwoong; Munch, Kasper; Hobolth, Asger; Dutheil, Julien Yann; Veeramah, Krishna R; Woerner, August E; Hammer, Michael F; Mailund, Thomas; Schierup, Mikkel Heide; Great Ape Genome Diversity Project.

    In: National Academy of Sciences. Proceedings, Vol. 112, No. 20, 04.05.2015.

    Publication: Research - peer-reviewJournal article

  14. Published

    The SMC' is a highly accurate approximation to the ancestral recombination graph. / Wilton, Peter R.; Carmi, Shai; Hobolth, Asger.

    In: Genetics (Print), Vol. 200, No. 1, 1, 01.05.2015, p. 343-355.

    Publication: Research - peer-reviewJournal article

  15. Published

    Inference of purifying and positive selection in three subspecies of chimpanzees (Pan troglodytes) from exome sequencing. / Bataillon, Thomas; Duan, Jinjie; Hvilsom, Christina; Jin, Xin; Li, Yingrui; Skov, Laurits; Glemin, Sylvain; Munch, Kasper; Jiang, Tao; Qian, Yu; Hobolth, Asger; Wang, Jun; Mailund, Thomas; Siegismund, Hans R; Schierup, Mikkel H.

    In: Genome Biology and Evolution, Vol. 7, No. 4, 04.2015, p. 1122-32.

    Publication: Research - peer-reviewJournal article

  16. Published

    The importance of distinguishing between the odds ratio and the incidence rate ratio in GWAS. / Waltoft, Berit Lindum; Pedersen, Carsten Bøcker; Nyegaard, Mette; Hobolth, Asger.

    In: B M C Medical Genetics, Vol. 16, No. 1, 2015, p. 71.

    Publication: Research - peer-reviewJournal article

  17. 2014
  18. Published

    Strong selective sweeps associated with ampliconic regions in great ape X chromosomes. / Nam, Kiwoong; Munch, Kasper; Hobolth, Asger; Y. Dutheil, Julien; Veeramah, Krishna; Woerner, August; F. Hammer, Michael; Ape Genome Diversity Project, Great; Mailund, Thomas; H. Schierup, Mikkel.

    In: arXiv, 24.02.2014.

    Publication: ResearchJournal article

  19. Published

    Efficient computation in the IM model. / Andersen, Lars Nørvang; Mailund, Thomas; Hobolth, Asger.

    In: Journal of Mathematical Biology, Vol. 68, No. 6, 2014, p. 1423-1451.

    Publication: Research - peer-reviewJournal article

  20. Published

    Markovian approximation to the finite loci coalescent with recombination along multiple sequences. / Hobolth, Asger; Jensen, Jens Ledet.

    In: Theoretical Population Biology, Vol. 98, 2014, p. 48-58.

    Publication: Research - peer-reviewJournal article

  21. Published

    Sampling and summary statistics of endpoint-conditioned paths in DNA sequence evolution. / Hobolth, Asger; Jeff, Thorne.

    Bayesian Phylogenetics: Methods, Algorithms, and Applications. ed. / Ming-Hui Chen; Lynn Kuo; Paul O. Lewis. Vol. 1 1. ed. C R C Press LLC, 2014.

    Publication: Research - peer-reviewBook chapter

  22. 2013
  23. Published

    Algorithms for Hidden Markov Models Restricted to Occurrences of Regular Expressions. / Tataru, Paula; Sand, Andreas; Hobolth, Asger; Mailund, Thomas; Pedersen, Christian Nørgaard Storm.

    In: Biology, Vol. 2, No. 4, 08.11.2013, p. 1282-1295.

    Publication: Research - peer-reviewJournal article

  24. Published

    Great ape genetic diversity and population history. / Prado-Martinez, Javier; Sudmant, Peter H; Kidd, Jeffrey M; Li, Heng; Kelley, Joanna L; Lorente-Galdos, Belen; Veeramah, Krishna R; Woerner, August E; O'Connor, Timothy D; Santpere, Gabriel; Cagan, Alexander; Theunert, Christoph; Casals, Ferran; Laayouni, Hafid; Munch, Kasper; Hobolth, Asger; Halager, Anders E; Malig, Maika; Hernandez-Rodriguez, Jessica; Hernando-Herraez, Irene; Prüfer, Kay; Pybus, Marc; Johnstone, Laurel; Lachmann, Michael; Alkan, Can; Twigg, Dorina; Petit, Natalia; Baker, Carl; Hormozdiari, Fereydoun; Fernandez-Callejo, Marcos; Dabad, Marc; Wilson, Michael L; Stevison, Laurie; Camprubí, Cristina; Carvalho, Tiago; Ruiz-Herrera, Aurora; Vives, Laura; Mele, Marta; Abello, Teresa; Kondova, Ivanela; Bontrop, Ronald E; Pusey, Anne; Lankester, Felix; Kiyang, John A; Bergl, Richard A; Lonsdorf, Elizabeth; Myers, Simon; Ventura, Mario; Gagneux, Pascal; Comas, David; Siegismund, Hans; Blanc, Julie; Agueda-Calpena, Lidia; Gut, Marta; Fulton, Lucinda; Tishkoff, Sarah A; Mullikin, James C; Wilson, Richard K; Gut, Ivo G; Gonder, Mary Katherine; Ryder, Oliver A; Hahn, Beatrice H; Navarro, Arcadi; Akey, Joshua M; Bertranpetit, Jaume; Reich, David; Mailund, Thomas; Schierup, Mikkel H; Hvilsom, Christina; Andrés, Aida M; Wall, Jeffrey D; Bustamante, Carlos D; Hammer, Michael F; Eichler, Evan E; Marques-Bonet, Tomas.

    In: Nature, Vol. 499, 2013, p. 471–475.

    Publication: Research - peer-reviewJournal article

  25. 2012
  26. Published

    A New Isolation with Migration Model along Complete Genomes Infers Very Different Divergence Processes among Closely Related Great Ape Species. / Mailund, Thomas; Halager, Anders E; Westergaard, Michael; Dutheil, Julien Y; Munch, Kasper; Andersen, Lars N; Lunter, Gerton; Prüfer, Kay; Scally, Aylwyn; Hobolth, Asger; Schierup, Mikkel H.

    In: P L o S Genetics, Vol. 8, No. 12, 2012, p. e1003125.

    Publication: Research - peer-reviewJournal article

  27. Published

    Ancestral population genomics. / Hobolth, Asger.

    Evolutionary Genomics: Statistical and Computational Methods. ed. / Maria Anisimova. Vol. 856 Springer, 2012. p. 293-313.

    Publication: Research - peer-reviewBook chapter

  28. Published

    Extensive X-linked adaptive evolution in central chimpanzees. / Hvilsom, Christina; Qian, Yu; Bataillon, Thomas; Li, Yingrui; Mailund, Thomas; Sallé, Bettina; Carlsen, Frands; Li, Ruiqiang; Zheng, Hancheng; Jiang, Tao; Jiang, Hui; Jin, Xin; Munch, Kasper; Hobolth, Asger; Siegismund, Hans R; Wang, Jun; Schierup, Mikkel Heide.

    In: National Academy of Sciences. Proceedings, 2012.

    Publication: Research - peer-reviewJournal article

  29. Published

    Insights into hominid evolution from the gorilla genome sequence. / Scally, Aylwyn; Dutheil, Julien Y; Hillier, LaDeana W; Jordan, Gregory E; Goodhead, Ian; Herrero, Javier; Hobolth, Asger; Lappalainen, Tuuli; Mailund, Thomas; Marques-Bonet, Tomas; McCarthy, Shane; Montgomery, Stephen H; Schwalie, Petra C; Tang, Y Amy; Ward, Michelle C; Xue, Yali; Yngvadottir, Bryndis; Alkan, Can; Andersen, Lars N; Ayub, Qasim; Ball, Edward V; Beal, Kathryn; Bradley, Brenda J; Chen, Yuan; Clee, Chris M; Fitzgerald, Stephen; Graves, Tina A; Gu, Yong; Heath, Paul; Heger, Andreas; Karakoc, Emre; Kolb-Kokocinski, Anja; Laird, Gavin K; Lunter, Gerton; Meader, Stephen; Mort, Matthew; Mullikin, James C; Munch, Kasper; O'Connor, Timothy D; Phillips, Andrew D; Prado-Martinez, Javier; Rogers, Anthony S; Sajjadian, Saba; Schmidt, Dominic; Shaw, Katy; Simpson, Jared T; Stenson, Peter D; Turner, Daniel J; Vigilant, Linda; Vilella, Albert J; Whitener, Weldon; Zhu, Baoli; Cooper, David N; de Jong, Pieter; Dermitzakis, Emmanouil T; Eichler, Evan E; Flicek, Paul; Goldman, Nick; Mundy, Nicholas I; Ning, Zemin; Odom, Duncan T; Ponting, Chris P; Quail, Michael A; Ryder, Oliver A; Searle, Stephen M; Warren, Wesley C; Wilson, Richard K; Schierup, Mikkel H; Rogers, Jane; Tyler-Smith, Chris; Durbin, Richard.

    In: Nature, Vol. 483, No. 7388, 2012, p. 169-75.

    Publication: Research - peer-reviewJournal article

  30. Published

    Markov bridges, bisection and variance reduction. / Asmussen, Søren; Hobolth, Asger.

    Monte Carlo and Quasi-Monte Carlo Methods 2010. ed. / Leszek Plaskota; Henryk Wozniakowski. Springer, 2012. p. 3-22 (Springer Proceedings in Mathematics & Statistics, Vol. 23).

    Publication: Research - peer-reviewArticle in proceedings

  31. Published

    The bonobo genome compared with the chimpanzee and human genomes. / Prüfer, Kay; Munch, Kasper; Hellmann, Ines; Akagi, Keiko; Miller, Jason R; Walenz, Brian; Koren, Sergey; Sutton, Granger; Kodira, Chinnappa; Winer, Roger; Knight, James R; Mullikin, James C; Meader, Stephen J; Ponting, Chris P; Lunter, Gerton; Higashino, Saneyuki; Hobolth, Asger; Dutheil, Julien; Karakoç, Emre; Alkan, Can; Sajjadian, Saba; Catacchio, Claudia Rita; Ventura, Mario; Marques-Bonet, Tomas; Eichler, Evan E; André, Claudine; Atencia, Rebeca; Mugisha, Lawrence; Junhold, Jörg; Patterson, Nick; Siebauer, Michael; Good, Jeffrey M; Fischer, Anne; Ptak, Susan E; Lachmann, Michael; Symer, David E; Mailund, Thomas; Schierup, Mikkel H; Andrés, Aida M; Kelso, Janet; Pääbo, Svante.

    In: Nature, Vol. 486, No. 7404, 2012, p. 527-31.

    Publication: Research - peer-reviewJournal article

  32. 2011
  33. Published

    Comparison of methods for calculating conditional expectations of sufficient statistics for continuous time Markov chains. / Tataru, Paula Cristina; Hobolth, Asger.

    In: B M C Bioinformatics, Vol. 12, No. 1, 05.12.2011, p. 465.

    Publication: Research - peer-reviewJournal article

  34. Published

    Markov bridges, bisection and variance reduction. / Asmussen, Søren; Hobolth, Asger.

    Thiele Centre, Institut for Matematiske Fag, Aarhus Universitet, 2011.

    Publication: ResearchWorking paper

  35. Published

    Comparative and demographic analysis of orang-utan genomes. / Locke, Devin P.; Hillier, LaDeana W.; Warren, Wesley C.; Yang, Shiaw-Pyng; Wang, Zhengyuan; Chinwalla, Asif T.; Minx, Pat; Mitreva, Makedonka; Cook, Lisa; Delehaunty, Kim D.; Fronick, Catrina; Schmidt, Heather; Fulton, Lucinda A.; Fulton, Robert S.; Nelson, Joanne O.; Magrini, Vincent; Pohl, Craig; Graves, Tina A.; Markovic, Chris; Weinstock, George M.; Mardis, Elaine R.; Wilson, Richard K.; Worley, Kim C.; Nazareth, Lynne V.; Muzny, Donna M.; Cree, Andy; Dinh, Huyen H.; Hume, Jennifer; Kovar, Christie L.; Fowler, Gerald R.; Rogers, Jeffrey; Gibbs, Richard A.; Lunter, Gerton; Meader, Stephen; Heger, Andreas; Ponting, Chris P.; Marques-Bonet, Tomas; Alkan, Can; Cheng, Lin; Cheng, Ze; Kidd, Jeffrey M.; Eichler, Evan E.; Faria, Rui; Fernando, Olga; Darré, Fleur; Farré, Domèmec; Gazave, Elodie; Oliva, Meritxell; Navarro, Arcadi; White, Simon; Searle, Stephen; Vilella, Albert J.; Chen, Yuan; Flicek, Paul; Herrero, Javier; Ma, Jian; Raney, Brian; Suh, Bernard; Haussler, David; Burhans, Richard; Ratan, Aakrosh; Harris, Robert S.; Miller, Webb; Roberto, Roberta; Capozzi, Oronzo; Archidiacono, Nicoletta; Rocchi, Mariano; Della Valle, Giuliano; Purgato, Stefania; Konkel, Miriam K.; Walker, Jerilyn A.; Batzer, Mark A.; Ullmer, Brygg; Smit, Adrian F. A.; Hubley, Robert; Casola, Claudio; Schrider, Daniel R.; Hahn, Matthew W.; Quesada, Victor; Puente, Xose S.; Ordoñez, Gonzalo R.; López-Otín, Carlos; Vinar, Tomas; Brejova, Brona; Kosiol, Carolin; Lawson, Heather A.; Taliwal, Vikas; Martins, André L.; Siepel, Adam; Ma, Xin; Degenhardt, Jeremiah; RoyChoudhury, Arindam; Bustamante, Carlos D.; Gutenkunst, Ryan N.; Mailund, Thomas; Dutheil, Julien; Hobolth, Asger; Schierup, Mikkel Heide; Ryder, Oliver A.; Yoshinaga, Yuko; de Jong, Pieter J.

    In: Nature, Vol. 469, 2011, p. 529-533.

    Publication: Research - peer-reviewJournal article

  36. Published
  37. Published

    Incomplete lineage sorting patterns among human, chimpanzee and orangutan suggest recent orangutan speciation and widespread selection. / Hobolth, Asger; Dutheil, Julien; Hawks, John; Schierup, Mikkel Heide; Mailund, Thomas.

    In: Genome Research, Vol. 21, No. 3, 2011, p. 349-356.

    Publication: Research - peer-reviewJournal article

  38. Published
  39. Published

    Summary statistics for endpoint-conditioned continuous-time Markov chains. / Hobolth, Asger; Jensen, Jens Ledet.

    In: Journal of Applied Probability, Vol. 48, No. 4, 2011, p. 911-924.

    Publication: Research - peer-reviewJournal article

  40. 2010
  41. Published

    Summary statistics for end-point conditioned continuous-time Markov chains. / Hobolth, Asger; Jensen, Jens Ledet.

    Århus : Thiele Centre, Institut for Matematiske Fag, Aarhus Universitet, 2010.

    Publication: ResearchWorking paper

  42. 2009
  43. Published

    Ancestral population genomics : the coalescent hidden Markov model approach. / Dutheil, Julien; Ganapathy, Ganesh; Hobolth, Asger; Mailund, Thomas; Uyenoyama, Marcy; Schierup, Mikkel Heide.

    In: Genetics, Vol. 183, No. 1, 2009, p. 259–274.

    Publication: Research - peer-reviewJournal article

  44. Published

    Simulation from endpoint-conditioned, continuous-time Markov chains on a finite state space, with applications to molecular evolution. / Hobolth, Asger; Stone, Eric.

    In: Annals of Applied Statistics, Vol. 3, No. 3, 2009, p. 1204-1231.

    Publication: Research - peer-reviewJournal article

  45. Published

    The genealogy, site frequency spectrum and ages of two nested mutant alleles. / Hobolth, Asger; Wiuf, Carsten Henrik.

    In: Theoretical Population Biology, Vol. 75, No. 4, 2009, p. 260-265.

    Publication: Research - peer-reviewJournal article

  46. 2008
  47. Published

    A Markov chain Monte Carlo Expectation Maximization Algorithm for Statistical Analysis of DNA Sequence Evolution with Neighbor-Dependent Substitution Rates. / Hobolth, Asger.

    In: Journal of Computational and Graphical Statistics, Vol. 17, No. 1, 2008, p. 138-162.

    Publication: Research - peer-reviewJournal article

  48. Published

    Importance sampling for the infinite sites model. / Hobolth, Asger; Uyenoyama, Marcy K; Wiuf, Carsten.

    In: Statistical Applications in Genetics and Molecular Biology, Vol. 7, No. 1, 2008.

    Publication: Research - peer-reviewJournal article

  49. 2007
  50. Published

    Bayesian regularization of diffusion tensor images. / Frandsen, Jesper; Hobolth, Asger; Østergaard, Leif; Vestergaard-Poulsen, Peter; Jensen, Eva Bjørn Vedel.

    In: Biostatistics, Vol. 8, No. 4, 2007, p. 784-799.

    Publication: Research - peer-reviewJournal article

  51. Published

    Genomic Relationships and Speciation Times of Human, Chimpanzee and Gorilla inferred from a Coalescent Hidden Markov Model. / Hobolth, Asger; Christensen, Ole Fredslund; Mailund, Thomas; Schierup, Mikkel Heide.

    2007. Poster session presented at Beyond the HapMap, Boston, United States.

    Publication: ResearchPoster

  52. Published

    Genomic relationships and speciation times of human, chimpanzee and gorilla inferred from a coalescent hidden Markov model. / Hobolth, Asger; Christensen, Ole Fredslund; Mailund, Thomas; Schierup, Mikkel Heide.

    In: P L o S Genetics, Vol. 3, No. 2, 2007.

    Publication: Research - peer-reviewJournal article

  53. 2006
  54. Published

    Regularization of Diffusion Tensor Fields in Axonal Fibre Tracking. / Frandsen, Jesper; Hobolth, Asger; Østergaard, Leif; Vestergaard-Poulsen, Peter; Vedel, Eva Bjørn.

    2006. Poster session presented at PhD Day 2006, The Faculty of Health Sciences, Aarhus, Denmark.

    Publication: ResearchPoster

  55. 2005
  56. Published

    Comparative analysis of protein coding sequences from human, mouse, and the domesticated pig  . / Jørgensen, Frank Grønlund; Hobolth, Asger; Hornshøj, H.; Bendixen, C.; Fredholm, M.; Schierup, Mikkel Heide.

    In: B M C Biology, Vol. 3, No. 2, 28.01.2005.

    Publication: Research - peer-reviewJournal article

  57. Published

    Shape discrimination by total curvature, with a view to cancer diagnostics. / Gardner, R.J.; Hobolth, Asger; Jensen, Eva Bjørn Vedel; Sørensen, Flemming Brandt.

    In: J. Microsc., Vol. 217, 2005, p. 49-59.

    Publication: Research - peer-reviewJournal article

  58. 2004
  59. Published

    Pseudo-likelihood analysis of context-dependent codon substitution models. / Christensen, O.F.; Hobolth, Asger; Jensen, J.L.

    2004. p. A-59.

    Publication: ResearchWorking paper

  60. Published

    Shape modelling of spatial particles from planar central sections - a case study. / Hannila, Marja-Leena; Jensen, Eva B. Vedel; Hobolth, Asger; Nyengaard, Jens Randel.

    In: Journal of Microscopy, Vol. 215, No. 2, 2004, p. 183-190.

    Publication: Research - peer-reviewJournal article

  61. 2002
  62. Published

    A note on design-based versus model-based variance estimation in stereology. / Hobolth, Asger; Jensen, Eva B. Vedel.

    In: Advances in Applied Probability, Vol. 34, 2002, p. 484-490.

    Publication: Research - peer-reviewJournal article

  63. Published

    Statistical shape analysis of featureless objects. / Hobolth, Asger.

    Department of Mathematical Sciences, Aarhus University, 2002. 143 p.

    Publication: ResearchPh.D. thesis

  64. Published

    Stereological analysis of shape. / Hobolth, Asger; Jensen, Eva Bjørn Vedel.

    In: Image Analysis and Stereology, Vol. 21, No. 4, 2002, p. S23-S29.

    Publication: Research - peer-reviewJournal article

  65. 2000
  66. Published

    Modelling stochastic chances in curve shape, with an application to cancer diagnostics. / Hobolth, A; Jensen, Eva B. Vedel.

    In: Advances in Applied Probability, Vol. 32, No. 2, 2000, p. 344-362.

    Publication: Research - peer-reviewJournal article