Anders Nykjær

  1. 2017
  2. Published

    Hidden Twins : SorCS Neuroreceptors Form Stable Dimers. / Januliene, Dovile; Manavalan, Arulmani; Ovesen, Peter Lund; Pedersen, Karen Marie; Thirup, Søren; Nykjær, Anders; Moeller, Arne.

    In: Journal of Molecular Biology, Vol. 29, No. 19, 15.09.2017, p. 2907-2917.

    Publication: Research - peer-reviewJournal article

  3. Published

    Progranulin gene variation affects serum progranulin levels differently in Danish bipolar individuals compared with healthy controls. / Buttenschøn, Henriette N; Nielsen, Marit N; Thotakura, Gangadaar; Lee, Chris W; Nykjær, Anders; Mors, Ole; Glerup, Simon.

    In: Psychiatric Genetics, Vol. 27, No. 3, 06.2017, p. 89-95.

    Publication: Research - peer-reviewJournal article

  4. Published
  5. 2016
  6. Published

    Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals. / Molgaard, Simon; Demontis, Ditte; Nicholson, Alexandra M; Finch, Nicole A; Petersen, Ronald C; Petersen, Claus M; Rademakers, Rosa; Nykjaer, Anders; Glerup, Simon.

    In: Experimental gerontology, Vol. 84, 11.2016, p. 96-100.

    Publication: Research - peer-reviewJournal article

  7. Published

    Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. / Goettsch, Claudia; Hutscheson, JD; Aikawa, M; Iwata, H; Pham, T; Nykjær, Anders; Kjølby, Mads Fuglsang; Rogers, Michel; Michel, T; Shibasaki, M; Hagita, S; Kramann, Raphael; Rader, Daniel J; Libby, Peter ; Singh, SA; Aikawa, Elena.

    In: Journal of Clinical Investigation, Vol. 126, No. 4, 01.04.2016, p. 1323.

    Publication: Research - peer-reviewJournal article

  8. Published

    SorCS2 is required for BDNF-dependent plasticity in the hippocampus. / Glerup, S; Bolcho, U; Bøggild, S; Vaegter, C B; Smith, A H; Nieto-Gonzalez, J L; Ovesen, P L; Pedersen, L F; Fjorback, A N; Kjolby, Mads; Login, H; Holm, M M; Andersen, O M; Nyengaard, J R; Willnow, T E; Jensen, K; Nykjaer, A; Jensen, Simon Mølgaard.

    In: Molecular Psychiatry, 2016.

    Publication: Research - peer-reviewJournal article

  9. 2015
  10. Published

    ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE. / Lisi, Simonetta; Madsen, Peder; Botta, Roberta; Petersen, Claus Munck; Nykjær, Anders; Latrofa, Francesco; Vitti, Paolo; Marinò, Michele.

    In: Endocrine Practice, Vol. 21, No. 9, 09.2015, p. 981-985.

    Publication: Research - peer-reviewJournal article

  11. 2014
  12. Published

    Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases. / Carlo, Anne-Sophie; Nykjaer, Anders; Willnow, Thomas E.

    In: Journal of Molecular Medicine, Vol. 92, No. 9, 09.2014, p. 905-11.

    Publication: Research - peer-reviewJournal article

  13. Published
  14. Published
  15. Published

    Pro-neurotrophins, sortilin, and nociception. / Lewin, Gary R; Nykjaer, Anders.

    In: The European journal of neuroscience, Vol. 39, No. 3, 02.2014, p. 363-74.

    Publication: Research - peer-reviewJournal article

  16. Published

    Getting closer to the function of the postsynaptic receptor SORCS3 in synaptic transmission and synaptic plasticity. / Bundgaard Christiansen, Gitte; Breiderhoff, Tilman; Nykjær, Anders; Jensen, Kimmo; Willnow, Thomas; Holm, Mai Marie.

    2014. Abstract from 9th FENS forum of neuroscience , Milan, Italy.

    Publication: ResearchConference abstract for conference

  17. Published

    Sortilins in neurotrophic factor signaling. / Glerup, S; Nykjaer, A; Vægter, Christian Bjerggaard.

    Sortilins in neurotrophic factor signaling. Vol. 220 2014. p. 165-89 (Handbook of Experimental Pharmacology).

    Publication: Research - peer-reviewBook chapter

  18. Published
  19. 2013
  20. Published

    Up-regulation of sortilin mediated by amyloid-β and p75(NTR) : safety lies in the middle course. / Coulson, Elizabeth J; Nykjaer, Anders.

    In: Journal of Neurochemistry, Vol. 127, No. 2, 10.2013, p. 149-51.

    Publication: Research - peer-reviewJournal article

  21. Published

    SORLA-Dependent and -Independent Functions for PACS1 in Control of Amyloidogenic Processes. / Burgert, Tilman; Schmidt, Vanessa; Caglayan, Safak; Lin, Fuyu; Füchtbauer, Annette; Füchtbauer, Ernst-Martin; Nykjaer, Anders; Carlo, Anne-Sophie; Willnow, Thomas E.

    In: Molecular and Cellular Biology, Vol. 33, No. 21, 03.09.2013, p. 4308-4320.

    Publication: Research - peer-reviewJournal article

  22. Published

    Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition. / Olsen, Ditte; Kaas, M.; Schwartz, O.; Nykjaer, A.; Glerup, S.

    In: Learning & Memory (Online), Vol. 20, No. 9, 01.09.2013, p. 499-504.

    Publication: Research - peer-reviewJournal article

  23. Published

    Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head. / Cases, Oliver; Perea-Gomez, Aitana; P. Aguiar, Diego ; Nykjær, Anders; Amsellem, Sabine ; Chandellier, Jacqueline ; Umbhauer, Muriel ; Cereghini, Silvia ; Madsen, Mette; Collignon, Jérôme ; Verroust, Pierre J.; Riou, Jean-François ; E. Creuzet, Sophie ; Kozyraki, Renata.

    In: Journal of Biological Chemistry, Vol. 288, No. 23, 07.06.2013, p. 16655-70.

    Publication: Research - peer-reviewJournal article

  24. Published

    Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation. / Capsoni, Simona; Amato, Gianluca; Vignone, Domenico; Criscuolo, Chiara; Nykjaer, Anders; Cattaneo, Antonino.

    In: Biochemical and Biophysical Research Communications, Vol. 431, No. 3, 15.02.2013, p. 579-85.

    Publication: Research - peer-reviewJournal article

  25. Published
  26. Published
  27. Published
  28. Published

    The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain. / Carlo, Anne-Sophie; Gustafsen, Camilla; Mastrobuoni, Guido; Nielsen, Morten Schallburg; Burgert, Tilman; Hartl, Daniela; Rohe, Michael; Nykjaer, Anders; Herz, Joachim; Heeren, Joerg; Kempa, Stefan; Petersen, Claus Munck; Willnow, Thomas E.

    In: Journal of Neuroscience, Vol. 33, No. 1, 2013, p. 358-70.

    Publication: Research - peer-reviewJournal article

  29. 2012
  30. Published

    SorLA regulates trafficking of Lipoprotein Lipase in polarized cells and astrocytes. / Klinger, Stine Christensen; Højland, Anne; Gustafsen, Camilla; Glerup, Simon; Kjølby, Mads Fuglsang; Helms, Hans Christian; Raarup, Merete Krog; Olivecrona, Gunilla ; Brodin, Birger; Petersen, Claus Munck; Nykjær, Anders; Nielsen, Morten Schallburg.

    2012. Poster session presented at Barriers of the CNS, New London NH, United States.

    Publication: Research - peer-reviewPoster

  31. Published

    Gentamicin Binds to Megalin as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats. / Dagil, Robert; O'Shea, Charlotte; Nykjaer, Anders; Bonvin, Alexandre M J J; Kragelund, Birthe Brandt.

    In: Journal of Biological Chemistry, 2012.

    Publication: Research - peer-reviewJournal article

  32. Published

    Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis. / Skeldal, Sune; Sykes, Alex M; Glerup, Simon; Matusica, Dusan; Palstra, Nickless; Autio, Henri; Boskovic, Zoran; Madsen, Peder; Castrén, Eero; Nykjaer, Anders; Coulson, Elizabeth J.

    In: Journal of Biological Chemistry, Vol. 287, No. 52, 2012, p. 43798-809.

    Publication: Research - peer-reviewJournal article

  33. Published

    Progranulin regulates neuronal outgrowth independent of Sortilin. / Gass, Jennifer; Lee, Wing C; Cook, Casey; Finch, Nicole; Stetler, Caroline; Jansen-West, Karen; Lewis, Jada; Link, Christopher D; Rademakers, Rosa; Nykjær, Anders; Petrucelli, Leonard.

    In: Molecular Neurodegeneration, Vol. 7, 2012, p. 33.

    Publication: Research - peer-reviewJournal article

  34. Published

    ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation. / Siao, Chia-Jen; Lorentz, Christina U; Kermani, Pouneh; Marinic, Tina; Carter, John David; McGrath, Kelly; Padow, Victoria A; Mark, Willie; Falcone, Domenick J; Cohen-Gould, Leona; Parrish, Diana C; Habecker, Beth A; Nykjaer, Anders; Ellenson, Lora H; Tessarollo, Lino; Hempstead, Barbara L.

    In: The Tohoku Journal of Experimental Medicine, Vol. 209, No. 12, 2012, p. 2291-305.

    Publication: Research - peer-reviewJournal article

  35. Published

    Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. / Schmidt, Vanessa; Baum, Katharina; Lao, Angelyn; Rateitschak, Katja; Schmitz, Yvonne; Teichmann, Anke; Wiesner, Burkhard; Petersen, Claus Munck; Nykjaer, Anders; Wolf, Jana; Wolkenhauer, Olaf; Willnow, Thomas E.

    In: E M B O Journal, Vol. 31, No. 1, 2012, p. 187-200.

    Publication: Research - peer-reviewJournal article

  36. Published

    Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing. / Fjorback, Anja W; Seaman, Matthew; Gustafsen, Camilla; Mehmedbasic, Arnela; Gokool, Suzanne; Wu, Chengbiao; Militz, Daniel; Schmidt, Vanessa; Madsen, Peder; Nyengaard, Jens R; E Willnow, Thomas; Christensen, Erik Ilsø; B Mobley, William; Nykjær, Anders; Andersen, Olav Michael.

    In: Journal of Neuroscience, Vol. 32, No. 4, 2012, p. 1467-1480.

    Publication: Research - peer-reviewJournal article

  37. Published

    Sortilin : a receptor to regulate neuronal viability and function. / Nykjaer, Anders; Willnow, Thomas E.

    In: Trends in Neurosciences, Vol. 35, No. 4, 2012, p. 261-70.

    Publication: Research - peer-reviewJournal article

  38. Published

    The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. / Shulga, Anastasia; Magalhães, Ana Cathia; Autio, Henri; Plantman, Stefan; di Lieto, Antonio; Nykjær, Anders; Carlstedt, Thomas; Risling, Mårten; Arumäe, Urmas; Castrén, Eero; Rivera, Claudio.

    In: Journal of Neuroscience, Vol. 32, No. 5, 2012, p. 1757-70.

    Publication: Research - peer-reviewJournal article

  39. 2011
  40. Published

    Sortilins: new players in lipoprotein metabolism. / Willnow, Thomas; Kjølby, Mads Fuglsang; Nykjær, Anders.

    In: Current Opinion in Lipidology, Vol. 22, No. 2, 04.2011, p. 79-85.

    Publication: Research - peer-reviewReview

  41. Published

    APP involvement in retinogenesis of mice. / Dinet, Virginie; An, Na; Ciccotosto, Giuseppe D; Bruban, Julien; Maoui, Agathe; Bellingham, Shayne A; Hill, Andrew F; Andersen, Olav M; Nykjaer, Anders; Jonet, Laurent; Cappai, Roberto; Mascarelli, Frédéric.

    In: Acta Neuropathologica, Vol. 121, No. 3, 01.03.2011, p. 351-63.

    Publication: Research - peer-reviewJournal article

  42. Published

    Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. / Vaegter, Christian B; Jansen, Pernille; Fjorback, Anja W; Glerup, Simon; Skeldal, Sune; Kjølby, Mads Fuglsang; Richner, Mette; Erdmann, Bettina; Nyengaard, Jens R; Tessarollo, Lino; Lewin, Gary R; Willnow, Thomas E; Chao, Moses V; Nykjaer, Anders.

    In: Nature Neuroscience, Vol. 14, No. 1, 01.01.2011, p. 54-61.

    Publication: Research - peer-reviewJournal article

  43. Published

    Impaired aldosterone responsiveness in corticosteroid deficient mice. / Sørensen, Mads Vaarby; Prætorius, Helle; Nykjær, Anders; Willnow, T; Leipziger, Jens Georg.

    In: Acta Physiologica (Print), Vol. 201, 2011, p. 169-177.

    Publication: Research - peer-reviewJournal article

  44. Published

    Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation. / Evans, Sarah Felice; Irmady, Krithi; Ostrow, Katya; Kim, Taeho; Nykjaer, Anders; Saftig, Paul; Blobel, Carl; Hempstead, Barbara L.

    In: Journal of Biological Chemistry, Vol. 286, No. 34, 2011, p. 29556-67.

    Publication: Research - peer-reviewJournal article

  45. Published

    Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons. / Tauris, Jacob; Gustafsen, Camilla; Christensen, Erik Ilsø; Jansen, Pernille; Nykjaer, Anders; Nyengaard, Jens R; Teng, Kenneth K; Schwarz, Elisabeth; Ovesen, Therese; Madsen, Peder; Petersen, Claus Munck.

    In: European Journal of Neuroscience, Vol. 33, 2011, p. 622-631.

    Publication: Research - peer-reviewJournal article

  46. Published

    Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR). / Skeldal, Sune; Matusica, Dusan; Nykjaer, Anders; Coulson, Elizabeth J.

    In: BioEssays, Vol. 33, No. 8, 2011, p. 614-25.

    Publication: Research - peer-reviewJournal article

  47. Published

    SorLA regulates lipoprotein lipase activity by intracellular trafficking. / Klinger, Stine Christensen; Glerup, Simon; Raarup, Merete Krog; Mari, MC; Nyegaard, Mette; Koster, G; Prabakaran, Thaneas; Nilsson, SK; Kjærgaard, Maj Margrethe; Bakke, O; Nykjær, Anders; Olivecrona, G; Petersen, Claus Munck; Nielsen, MS.

    2011. Abstract from PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.

    Publication: ResearchConference abstract for conference

  48. Published

    SorLA regulates lipoprotein lipase activity by intracellular trafficking. / Klinger, Stine Christensen; Glerup, Simon; Raarup, Merete Krog; Mari, MC; Nyegaard, Mette; Koster, G; Prabakaran, Thaneas; Nilsson, SK; Kjærgaard, Maj Margrethe; Bakke, O; Nykjær, Anders; Olivecrona, G; Petersen, Claus Munck; Nielsen, MS.

    2011. Poster session presented at PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.

    Publication: ResearchPoster

  49. Published

    SorLA regulates the activity of lipoprotein lipase by intracellular trafficking. / Klinger, Stine C; Glerup, Simon; Raarup, Merete K; Mari, Muriel C; Nyegaard, Mette; Koster, Gerbrand; Prabakaran, Thaneas; Nilsson, Björn Stefan; Kjaergaard, Maj M; Bakke, Oddmund; Nykjær, Anders; Olivecrona, Gunilla; Petersen, Claus Munck; Nielsen, Morten Schallburg.

    In: Journal of Cell Science, Vol. 124, No. Pt 7, 2011, p. 1095-105.

    Publication: Research - peer-reviewJournal article

  50. Published

    The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice. / Richner, Mette; Bjerrum, Ole Jannik; Nykjær, Anders; Vægter, Christian Bjerggaard.

    In: Journal of Visualized Experiments, Vol. 54, 2011.

    Publication: Research - peer-reviewJournal article

  51. 2010
  52. Published

    Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. / Hu, Fenghua; Padukkavidana, Thihan; Vægter, Christian Bjerggaard; Brady, Owen A; Zheng, Yanqiu; Mackenzie, Ian R; Feldman, Howard H; Nykjaer, Anders; Strittmatter, Stephen M.

    In: Neuron, Vol. 68, No. 4, 18.11.2010, p. 654-67.

    Publication: Research - peer-reviewJournal article

  53. Published

    Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin. / Wähe, Anna; Kasmapour, Bahram; Schmaderer, Christoph; Liebl, David; Sandhoff, Konrad; Nykjaer, Anders; Griffiths, Gareth; Gutierrez, Maximiliano G.

    In: Journal of Cell Science, Vol. 123, No. Pt 14, 15.07.2010, p. 2502-11.

    Publication: Research - peer-reviewJournal article

  54. Published

    Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease. / Mufson, Elliott J; Wuu, Joanne; Counts, Scott E; Nykjaer, Anders.

    In: Neuroscience Letters, Vol. 471, No. 3, 08.03.2010, p. 129-33.

    Publication: Research - peer-reviewJournal article

  55. Published

    Cellular uptake of steroid carrier proteins--mechanisms and implications. / Willnow, Thomas E; Nykjaer, Anders.

    In: Molecular and Cellular Endocrinology, Vol. 316, No. 1, 05.03.2010, p. 93-102.

    Publication: Research - peer-reviewJournal article

  56. Published

    Identification of a linear epitope in sortilin that partakes in pro-neurotropin binding. / Andersen, O.S.; Boisguerin, P.; Glerup, Simon; Skeldal, Sune; Volkmer, R.; Wilnow, T.E.; Nykjær, Anders; Andersen, Olav Michael.

    In: Journal of Biological Chemistry, 2010, p. 12210-12222.

    Publication: ResearchJournal article

  57. Published

    Increased synaptic GABAergic inhibition in dentate gyrus of mice deficient of sortilin. : Joint meeting of the Scandinavian and German Physiological Societies Mar. 27 2010 - Mar. 30 2010 Copenhagen, Denmark. / Vardya, Irina; Holm, Mai Marie; Dósa, Zita; Nieto-Gonzalez, Jose Luis; Nykjær, Anders; Jensen, Kimmo.

    2010. Poster session presented at Joint meeting of the Scandinavian and German Physiological Societies, Copenhagen, Denmark.

    Publication: ResearchPoster

  58. Published

    SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2. / Reiche, Juliane; Theilig, Franziska; Rafiqi, Fatema H; Militz, Daniel; Mutig, Kerim; Todiras, Mihail; Christensen, Erik Ilsø; Ellison, David H; Bader, Michael; Nykjaer, Anders; Bachmann, Sebastian; Alessi, Dario; Willnow, Thomas E.

    In: Molecular and Cellular Biology, Vol. 30, 2010, p. 3027-3037.

    Publication: Research - peer-reviewJournal article

  59. Published

    Sortilin-Mediated Endocytosis Determines Levels of the Fronto-Temporal Dementia Protein, Progranulin. / Hu, Fenghua; Padukkavidana, Thihan; Vægter, Christian Bjerggaard; Brady, Owen; Zheng, Yanqiu; Mackenzie, Ian; Feldman, Howard; Nykjær, Anders; Strittmatter, Stephen.

    In: Neuron, Vol. 68, No. 4, 2010, p. 654-667.

    Publication: Research - peer-reviewJournal article

  60. Published

    Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. / Kjølby, Mads Fuglsang; Andersen, Olav Michael; Breiderhoff, Tilman; Fjorback, Anja Nawarecki; Pedersen, Karen-Marie; Madsen, Peder Søndergaard; Jansen, Pernille; Heeren, Jörg; Willnow, Thomas; Nykjær, Anders.

    In: Cell Metabolism, Vol. 12, No. 3, 2010, p. 213-223.

    Publication: Research - peer-reviewJournal article

  61. 2009
  62. Published

    Assessing low-dose gentamicin-induced kidney injury in rats by analysis of urine. / Nykjaer, Anders; Schambye, Hans; Pedersen, Anders H; Nielsen, Henning.

    In: Journal of Pharmacological and Toxicological Methods, Vol. 60, No. 3, 2009, p. 316-20.

    Publication: Research - peer-reviewJournal article

  63. Published

    Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. / Rohe, Michael; Synowitz, Michael; Glass, Rainer; Paul, Steven M; Nykjaer, Anders; Willnow, Thomas E.

    In: Journal of Neuroscience, Vol. 29, No. 49, 2009, p. 15472-8.

    Publication: Research - peer-reviewJournal article

  64. Published

    Cubilin and Megalin Co-Localize in the Neonatal Inner Ear. / Tauris, Jacob; Christensen, Erik Ilsø; Nykjær, Anders; Jacobsen, Christian; Petersen, Claus Munck; Ovesen, Therese.

    In: Audiology and Neuro-Otology, Vol. 14, No. 4, 2009, p. 267-278.

    Publication: Research - peer-reviewJournal article

  65. Published

    Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus. / Holm, Mai Marie; Nieto-Gonzales, Jose Luis; Vardya, Irina; Vægter, Christian Bjerggaard; Nykjær, Anders; Jensen, Kimmo.

    In: Journal of Neuroscience, Vol. 29, No. 40, 2009, p. 12412-8.

    Publication: Research - peer-reviewJournal article

  66. Published

    The neurotrophin precursor proNT-3 promotes Sortilin:p75NTR complex formation and induces apoptosis. / Gustafsen, Camilla; Tauris, Jacob; Christensen, Erik Ilsø; Jansen, Pernille; Nykjær, Anders; Teng, Kenneth K; Schwarz, Elisabeth; Madsen, Peder Søndergaard; Petersen, Claus Munck.

    2009. Poster session presented at Society for Neuroscience 2009, Chicago, United States.

    Publication: ResearchPoster

  67. Published
  68. 2008
  69. Published

    Different motifs regulate trafficking of SorCS1 isoforms. / Nielsen, Morten S; Keat, Sady J; Hamati, Jida W; Madsen, Peder; Gutzmann, Jakob J; Engelsberg, Arne; Pedersen, Karen-Marie; Gustafsen, Camilla; Nykjaer, Anders; Gliemann, Jørgen; Hermans-Borgmeyer, Irm; Kuhl, Dietmar; Petersen, Claus M; Hermey, Guido.

    In: Traffic, Vol. 9, No. 6, 2008, p. 980-94.

    Publication: Research - peer-reviewJournal article

  70. Published

    Different motifs regulate trafficking of SorCS1 isoforms. / Nielsen, Morten Schallburg; Keat, SJ; Hamati, JW; Madsen, Peder Søndergaard; Gutzmann, JJ; Engelsberg, A; Pedersen, KM; Gustafsen, Camilla; Nykjær, Anders; Gliemann, Jørgen; Hermans-Borgmeyer, I; Petersen, Claus Munck; Hermey, Guido.

    In: Traffic, Vol. 9, No. 6, 2008, p. 980-94.

    Publication: Research - peer-reviewJournal article

  71. Published

    Endocytosis of sex stereoids: The hypothesis of free hormones revisited. / Willnow, T.E.; Hammes, A.; Nykjær, Anders.

    In: Annales d'Endocrinologie, Vol. 69, 2008, p. 101-2.

    Publication: Research - peer-reviewJournal article

  72. Published

    Sortilin positively modulates survival signaling by mature neurotrophins. / Vægter, Christian Bjerggaard; Jansen, Pernille; Erdmann, Bettina; WillNow, Thomas; Lewin, Garry; Tessarollo, Lino; Nykjær, Anders.

    2008. Poster session presented at Society for Neuroscience 38th Annual Meeting, Washington, United States.

    Publication: ResearchPoster

  73. Published
  74. Published

    VPs10p-domain receptors . central regulators of neuronal viability. / Willnow, T.E.; Petersen, Claus Munck; Nykjær, Anders.

    In: Nature Reviews. Neuroscience, Vol. 9, 2008, p. 899-909.

    Publication: Research - peer-reviewJournal article

  75. 2007
  76. Published

    Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP. / Muhl, Lars; Nykjaer, Anders; Wygrecka, Malgorzata; Monard, Denis; Preissner, Klaus T; Kanse, Sandip M.

    In: Biochemical Journal, Vol. 404, No. 2, 2007, p. 191-6.

    Publication: Research - peer-reviewJournal article

  77. Published

    Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. / Jansen, Pernille; Giehl, Klaus; Nyengaard, Jens R; Teng, Kenneth; Lioubinski, Oleg; Sjoegaard, Susanne S; Breiderhoff, Tilman; Gotthardt, Michael; Lin, Fuyu; Eilers, Andreas; Petersen, Claus M; Lewin, Gary R; Hempstead, Barbara L; Willnow, Thomas E; Nykjaer, Anders.

    In: Nature Neuroscience, Vol. 10, No. 11, 2007, p. 1449-57.

    Publication: Research - peer-reviewJournal article

  78. 2006
  79. Published

    Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin. / Petersen, Helle Heibroch; Andreassen, Thomas K; Breiderhoff, Tilman; Bräsen, Jan Hinrich; Schulz, Herbert; Gross, Volkmar; Gröne, Hermann-Josef; Nykjaer, Anders; Willnow, Thomas E.

    In: Molecular and Cellular Biology, Vol. 26, No. 19, 2006, p. 7236-45.

    Publication: Research - peer-reviewJournal article

  80. Published
  81. Published

    Response: cellular uptake of ex steroid hormones. / Willnow, T. E.; Nykjær, Anders.

    In: Cell, Vol. 124, 2006, p. 456-457.

    Publication: Research - peer-reviewJournal article

  82. Published

    Tumour necrosis factor-α convertase mediates ectodomain shedding of Vps10p-domain receptor family members. / Hermey, Guido; Sjøgaard, Susanne; Petersen, Claus Munck; Nykjær, Anders; Gliemann, Jørgen.

    In: Biochem. J., Vol. 395, No. 2, 2006, p. 285-293.

    Publication: Research - peer-reviewJournal article

  83. Published

    Tumour necrosis factor-alpha convertase mediates ectodomain shedding of Vps10p-domain receptor family members. / Hermey, G.; Sjøgaard, Susanne; Petersen, Claus Munck; Nykjær, Anders; Gliemann, Jørgen.

    In: Biochem. J., 2006.

    Publication: Research - peer-reviewJournal article

  84. 2005
  85. Published

    Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. / Andersen, O. M.; Reiche, J.; Schmidt, V.; Gotthardt, M.; Spoelgen, R.; Behlke, J.; von Arnim, C. A.; Breiderhoff, T.; Jansen, Pernille; Wu, X.; Bales, K. R.; Cappai, R.; Masters, C. L.; Gliemann, Jørgen; Mufson, E. J.; Hyman, B. T.; Paul, S. M.; Nykjær, Anders; Willnow, T. E.

    In: National Academy of Sciences. Proceedings, Vol. 102, No. 38, 2005, p. 13461-13466.

    Publication: Research - peer-reviewJournal article

  86. Published

    Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. / Andersen, Olav; Reiche, J.; Schmidt, V.; Gotthardt, M.; Spoelgen, R.; Behlke, J.; Arnim, C.A. von; Breiderhoff, T.; Jansen, Pernille; Wu, X.; Bales, K.R.; Cappai, R.; Masters, C.L.; Gliemann, Jørgen; Mufson, E.J.; Hyman, B.T.; Paul, S.M.; Nykjær, Anders; Wilnow, T.E.

    In: National Academy of Sciences. Proceedings, 2005, p. 13461-13466.

    Publication: Research - peer-reviewJournal article

  87. Published

    ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. / Teng, H. K.; Teng, K. K.; Lee, R.; Wright, S.; Tevar, S.; Almeida, R. D.; Kermani, P.; Torkin, R.; Chen, Z. Y.; Lee, F. S.; Kraemer, R. T.; Nykjær, Anders; Hempstead, B. L.

    In: Journal of Neuroscience, Vol. 25, 2005, p. 5455-5463.

    Publication: Research - peer-reviewJournal article

  88. Published

    p75NTR – To live or let die. / Nykjær, Anders; Willnow, T.E.; Pedersen, Jens Claus Munck.

    In: Curr. Opin. Neurobiol., Vol. 15, 2005, p. 49-57.

    Publication: ResearchReview

  89. Published

    Role of endocytosis in cellular uptake of sex steroids. / Hammes, A.; Andreassen, Thomas Kjærgaard; Spoelgen, R.; Raila, J.; Huebner, N.; Schulz, H.; Metzger, J.; Schweigert, F. J.; Luppa, P. B.; Nykjær, Anders; Willnow, T. E.

    In: Cell, Vol. 122, 2005, p. 751-762.

    Publication: Research - peer-reviewJournal article

  90. Published

    Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. / Chen, Z. Y.; Ieraci, A.; Teng, H. K.; Dall, H.; Meng, C. X.; Herrera, D. G.; Nykjær, Anders; Hempstead, B. L.; Lee, F. S.

    In: Journal of Neuroscience, Vol. 25, 2005, p. 6155-6166.

    Publication: Research - peer-reviewJournal article

  91. 2004
  92. Published

    Endocytic Pathways for 25-(OH) Vitamin D3. / Willnow, T.E.; Nykjær, Anders.

    In: Elsevier Academic Press, 2004, p. 153-166.

    Publication: ResearchReview

  93. Published

    Functional organization of the sortilin Vps10p domain. / Westergaard, U.B.; Sørensen, Esben Skipper; Hermey, G.; Nielsen, Morten Schallburg; Nykjær, Anders; Kirkegaard, Kirstine; Jacobsen, Christian; Gliemann, Jørgen; Madsen, Peder Søndergaard; Pedersen, Jens Claus Munck.

    In: Journal of Biological Chemistry, Vol. 279, 2004, p. 50221-50229.

    Publication: Research - peer-reviewJournal article

  94. Published

    Sortilin is essential for proNGF-induced neuronal cell death. / Nykjær, Anders; Lee, R.; Teng, K.K.; Jansen, Pernille; Madsen, Peder Søndergaard; Nielsen, Morten Schallburg; Jacobsen, Christian; Kliemannel, M.; Schwarz, E.; Willnow, T.E.; Hempstead, B.L.; Pedersen, Jens Claus Munck.

    In: Nature, Vol. 427, 2004, p. 843-848.

    Publication: Research - peer-reviewJournal article

  95. Published

    The mosaic receptor sorLA/LR11 binds components of the plasminogen activating system and PDGF-BB similarity to low density lipoprotein receptor-related protein (LRP1) but mediates slow internalization of bound. / Gliemann, J.; Hermey, G.; Nykjær, Anders; Petersen, C.M.; Jacobsen, C.; Andreasen, Peter.

    In: Biochem. J., Vol. 381, 2004, p. 203-212.

    Publication: Research - peer-reviewJournal article

  96. Published
  97. 2003
  98. Published

    From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia. / Muller, D.; Nykjær, Anders; Willnow, T.E.

    In: Ann Med, No. 35, 2003, p. 290-299.

    Publication: ResearchReview

  99. Published

    Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. / Leheste, J.R.; Melsen, F.; Wellner, M.; Jansen, Pernille; Schlichting, U.; Renner-Muller, I.; Andreassen, T.T.; Wolf, E.; Bachmann, S.; Nykjær, Anders; Willnow, T.E.

    In: F A S E B Journal, No. 17, 2003, p. 247-249.

    Publication: ResearchJournal article

  100. 2002
  101. Published

    Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism. / Hilpert, J.; Wogensen, L.; Thykjaer, T.; Wellner, M.; Schlichting, U.; Ørntoft, Torben Falck; Bachmann, S.; Nykjær, Anders; Willnow, T.E.

    In: Kidney International, Vol. 62, No. 5, 2002, p. 1672-1681.

    Publication: ResearchJournal article

  102. Published

    Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3. / Willnow, T.E.; Nykjær, Anders.

    In: Curr Opin Lipidol, Vol. 13, No. 3, 2002, p. 255-260.

    Publication: ResearchReview

  103. Published

    The low-density lipoprotein receptor gene family: a cellular Swiss army knife? / Nykjær, Anders; Willnow, T.E.

    In: Trends Cell Biol., Vol. 12, No. 6, 2002, p. 273-280.

    Publication: ResearchReview

  104. 2001
  105. Published

    A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney. / Burmeister, R.; Boe, I.M.; Nykjær, Anders; Jacobsen, Christian; Moestrup, Søren Kragh; Verroust, P.; Christensen, Erik Ilsø; Lund, J.; Willnow, T.E.

    In: Journal of Biological Chemistry, Vol. 276, 2001, p. 13295-13301.

    Publication: Research - peer-reviewJournal article

  106. Published

    Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3). / Nykjær, Anders; Fyfe, J.C.; Kozyraki, R.; Leheste, J.R.; Jacobsen, Christian; Nielsen, Morten Schallburg; Verroust, P.J.; Aminoff, M.; de la Chapelle, A.; Moestrup, Søren Kragh; Ray, R.; Gliemann, Jørgen; Willnow, T.E.; Christensen, Erik Ilsø.

    In: National Academy of Sciences. Proceedings, Vol. 98, 2001, p. 13895-13900.

    Publication: Research - peer-reviewJournal article

  107. Published

    Efficient eukaryotic expression system for authentic human sex hormone-binding globulin. / Hilpert, J.; Vorum, Henrik; Burmeister, R.; Spoelgen, R.; Grishkovskaya, I.; Misselwitz, R.; Nykjær, Anders; Willnow, T.E.

    In: Biochem. J., Vol. 360, 2001, p. 609-615.

    Publication: ResearchJournal article

  108. Published
  109. 1999
  110. Published

    An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3 . / Nykjær, Anders; Dragun, D.; Walther, D.; Vorum, Henrik; Christian, Christian; Herz, J.; Melsen, F.; Christensen, Erik Ilsø; Willnow, T.E.

    In: Gekkan Saibo, Vol. 96, 1999, p. 507-515.

    Publication: Research - peer-reviewJournal article

  111. Published

    An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. / Nykjaer, A; Dragun, D; Walther, D; Vorum, H; Jacobsen, C; Herz, J; Melsen, F; Christensen, E I; Willnow, T E.

    In: Cell, Vol. 96, No. 4, 1999, p. 507-15.

    Publication: Research - peer-reviewJournal article

  112. Published

    Evidence for an essential role of megalin in transepithelial transport of retinol. / Christensen, Erik Ilsø; Moskaug, J.Ø.; Vorum, Henrik; Jacobsen, Christian; Gundersen, T.E.; Nykjær, Anders; Blomhoff, R.; Willnow, T.E.; Moestrup, Søren Kragh.

    In: American Society of Nephrology. Journal, Vol. 10, 1999, p. 685-695.

    Publication: Research - peer-reviewJournal article

  113. Published

    Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development. / Hermans-Borgmeyer, I; Hermey, G; Nykjaer, A; Schaller, C.

    In: Brain Research, Vol. 65, No. 2, 1999, p. 216-9.

    Publication: Research - peer-reviewJournal article

  114. Published

    Lipoprotein receptors: new roles for ancient proteins. / Willnow, T E; Nykjaer, A; Herz, J.

    In: Nature Cell Biology, Vol. 1, No. 6, 1999, p. E157-62.

    Publication: Research - peer-reviewJournal article

  115. Published

    Megalin antagonizes activation of the parathyroid hormone receptor. / Hilpert, J; Nykjær, Anders; Jacobsen, Christian; Wallukat, G; Nielsen, Rikke; Moestrup, Søren Kragh; Haller, H; Luft, F.C.; Christensen, Erik Ilsø; Willnow, T.E.

    In: Journal of Biological Chemistry, Vol. 274, 1999, p. 5620-5625.

    Publication: Research - peer-reviewJournal article

  116. Published

    Megalin knockout mice as an animal model of low molecular weight proteinuria. / Leheste, J.-R.; Rolinski, B.; Vorum, Henrik; Hilpert, J.; Nykjær, Anders; Jacobsen, Christian; Aucouturier, P.; Moskaug, J.Ø.; Otto, A.; Christensen, Erik Ilsø; Willnow, T.E.

    In: American Journal of Pathology, Vol. 155, 1999, p. 1361-1370.

    Publication: Research - peer-reviewJournal article

  117. 1998
  118. Published

    The 275 kDa cation-independent mannose-6-phosphate receptor targets the urokinase receptor to lysosomes via a novel binding interaction. / Nykjær, Anders; Christensen, Erik Ilsø; Vorum, Henrik; Hager, Henrik; Petersen, Claus Munck; Røigaard, H.; Min, H.Y.; Vilhardt, F.; Møller, L.B.; Kornfeld, S.; Gliemann, Jørgen.

    In: J. Cell. Biol., Vol. 141, 1998, p. 815-828.

    Publication: Research - peer-reviewJournal article

  119. Published

    Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex. / Hermans-Borgmeyer, I; Hampe, W; Schinke, B; Methner, A; Nykjaer, A; Süsens, U; Fenger, U; Herbarth, B; Schaller, H C.

    In: Mechanisms of Development, Vol. 70, No. 1-2, 1998, p. 65-76.

    Publication: Research - peer-reviewJournal article

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