Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)

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    Kai Triebner, Department of Clinical Science, University of Bergen, Jonas Lies veg 87, 5021 Bergen, Norway; Core Facility for Metabolomics, University of Bergen, Jonas Lies veg 87, 5021, Bergen, Norway. Electronic address: kai.triebner@uib.no., NorgeSimone Accordini, Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Institute of Biology II, Strada Le Grazie 8, 37134 Verona, Italy., ItalienLucia Calciano, Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Institute of Biology II, Strada Le Grazie 8, 37134 Verona, Italy., ItalienAne Johannessen, Department of Occupational Medicine, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway; Centre for International Health, University of Bergen, Jekteviksbakken 31, 5009 Bergen Bergen, Norway., NorgeBryndís Benediktsdóttir, Faculty of Medicine, University of Iceland, Reykjavik, Iceland., IslandErsilia Bifulco, Department of Clinical Science, University of Bergen, Jonas Lies veg 87, 5021 Bergen, Norway; Core Facility for Metabolomics, University of Bergen, Jonas Lies veg 87, 5021, Bergen, Norway., NorgePascal Demoly, Department of Pulmonology - Division of Allergy, University Hospital of Montpellier, University Montpellier, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier, France; Sorbonne University, French National Institute of Health and Medical Research, Pierre Louis Institute of Epidemiology and Public Health, 56 Boulevard Vincent-Auriol, 75646 Paris, France., FrankrigShyamali C Dharmage, Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, 207 Bouverie Street, 3052 Carlton, Australia., AustralienKarl A Franklin, Department of Surgical and Perioperative Sciences, Surgery, Umea University, Koksvagen 11, 90185 Umea, Sweden., SverigeJudith Garcia-Aymerich, ISGlobal, Doctor Aiguader 88, 08003 Barcelona, Spain; University Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain; CIBER Epidemiology and Public Health, Doctor Aiguader 88, 08003 Barcelona, Spain., SpanienJosé Antonio Gullón Blanco, Pneumology Department University Hospital San Agustín, Camino Heros 4, 33410, Avilés, Spain., SpanienJoachim Heinrich, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilian University Munich, Ziemssenstrasse 1, 80336 Munich, Germany., TysklandMathias Holm, Department of Occupational and Environmental Medicine, University of Gothenburg, Medicinaregatan 16A, 41390 Gothenburg, Sweden., SverigeDebbie Jarvis, National Heart and Lung Institute, 1b Manresa Road SW3 6LR, Imperial College, London, United Kingdom., StorbritannienRain Jõgi, Department of Lung Medicine, Tartu University Hospital, Lung Clinic, Riia 167, Tartu 51014, Estonia., EstlandEva Lindberg, Department of Medical Sciences, Respiratory, allergy and sleep research, Uppsala University, Akademiska sjukhuset Ing. 40, Uppsala, Sweden., SverigeJesús Martínez-Moratalla, Pulmonology Service, Albacete University Hospital Complex, Health Service of Castilla - La Mancha, Albacete, Spain; Faculty of Medicine of Albacete, Castilla-La Mancha University, Albacete, Spain., SpanienNerea Muniozguren Agirre, Unit of Epidemiology and Public Health, Department of Health, Basque Government, Alameda Rekalde 39A, 48008 Bilbao, Spain., SpanienIsabelle Pin, Department of Pediatrics, University Hospital Grenoble Alpes, French National Institute of Health and Medical Research, Institute for Advanced Biosciences, University Grenoble Alpes, CS 10217, 38043 Grenoble cedex 9, France., FrankrigNicole Probst-Hensch, Swiss Tropical and Public Health Institute, Socinstrasse 58, 4002 Basel, Switzerland; Department of Public Health, University of Basel, Petersplatz 1, 4001 Basel, Switzerland., SchweizChantal Raherison, U1219, Bordeaux Population Health Research, Bordeaux University, 146 rue Leo Saignat, 33076 Bordeaux, France., FrankrigJosé Luis Sánchez-Ramos, Department of Nursing, University of Huelva, Avenida Tres de Marzo, s/n 21071, Huelva, Spain., Spanien
  • Vivi Schlünssen
  • Cecilie Svanes, Department of Occupational Medicine, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway; Centre for International Health, University of Bergen, Jekteviksbakken 31, 5009 Bergen Bergen, Norway., NorgeSteinar Hustad, Department of Clinical Science, University of Bergen, Jonas Lies veg 87, 5021 Bergen, Norway; Core Facility for Metabolomics, University of Bergen, Jonas Lies veg 87, 5021, Bergen, Norway., NorgeBénédicte Leynaert, 31 Team of Epidemiology, French National Institute of Health and Medical Research (INSERM), UMR1152, Paris, France., FrankrigFrancisco Gómez Real, Department of Clinical Science, University of Bergen, Jonas Lies veg 87, 5021 Bergen, Norway; Department of Gynecology and Obstetrics, Haukeland University Hospital, Jonas Lies veg 65, 5021 Bergen, Norway., Norge

OBJECTIVES: Menopause involves hypoestrogenism, which is associated with numerous detrimental effects, including on respiratory health. Hormone replacement therapy (HRT) is often used to improve symptoms of menopause. The effects of HRT on lung function decline, hence lung ageing, have not yet been investigated despite the recognized effects of HRT on other health outcomes.

STUDY DESIGN: The population-based multi-centre European Community Respiratory Health Survey provided complete data for 275 oral HRT users at two time points, who were matched with 383 nonusers and analysed with a two-level linear mixed effects regression model.

MAIN OUTCOME MEASURES: We studied whether HRT use was associated with the annual decline in forced vital capacity (FVC) and forced expiratory volume in one second (FEV1).

RESULTS: Lung function of women using oral HRT for more than five years declined less rapidly than that of nonusers. The adjusted difference in FVC decline was 5.6 mL/y (95%CI: 1.8 to 9.3, p = 0.01) for women who had taken HRT for six to ten years and 8.9 mL/y (3.5 to 14.2, p = 0.003) for those who had taken it for more than ten years. The adjusted difference in FEV1 decline was 4.4 mL/y (0.9 to 8.0, p = 0.02) with treatment from six to ten years and 5.3 mL/y (0.4 to 10.2, p = 0.048) with treatment for over ten years.

CONCLUSIONS: In this longitudinal population-based study, the decline in lung function was less rapid in women who used HRT, following a dose-response pattern, and consistent when adjusting for potential confounding factors. This may signify that female sex hormones are of importance for lung ageing.

OriginalsprogEngelsk
TidsskriftMaturitas
Vol/bind120
Sider (fra-til)29-34
Antal sider6
ISSN0378-5122
DOI
StatusUdgivet - feb. 2019

Bibliografisk note

Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

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