Alcohol consumption and its interaction with adiposity-associated genetic variants in relation to subsequent changes in waist circumference and body weight

Publikation: Forskning - peer reviewTidsskriftartikel

DOI

  • Jeanett F Rohde
    Jeanett F RohdeResearch Unit for Dietary Studies at the Parker Institute, Bispebjerg and Frederiksberg Hospital, the Capital Region, Copenhagen, Nordre Fasanvej 57, entrance 5, ground floor, 2000, Frederiksberg, Denmark.Department of Clinical Epidemiology (Formerly 'Institute of Preventive Medicine'), Bispebjerg and Frederiksberg Hospital, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, first floor, 2000, Frederiksberg, Denmark.Danmark
  • Lars Ängquist
    Lars ÄngquistDepartment of Clinical Epidemiology (Formerly 'Institute of Preventive Medicine'), Bispebjerg and Frederiksberg Hospital, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, first floor, 2000, Frederiksberg, Denmark.Danmark
  • Sofus C Larsen
    Sofus C LarsenDepartment of Clinical Epidemiology (Formerly 'Institute of Preventive Medicine'), Bispebjerg and Frederiksberg Hospital, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, first floor, 2000, Frederiksberg, Denmark.Research Unit for Dietary Studies at the Parker Institute, Bispebjerg and Frederiksberg Hospital, the Capital Region, Copenhagen, Nordre Fasanvej 57, entrance 5, ground floor, 2000, Frederiksberg, Denmark.Danmark
  • Janne S Tolstrup
    Janne S TolstrupNational Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5a, DK-1353 Copenhagen K, Denmark. Electronic address: pvp@niph.dk.Danmark
  • Lise Lotte N Husemoen
    Lise Lotte N HusemoenResearch Centre for Prevention and Health, Capital Region of Denmark, Nordre Ringvej 57, building 84-85, 2600, Glostrup, Denmark.Danmark
  • Allan Linneberg
    Allan LinnebergDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, København N, Denmark.Research Centre for Prevention and Health, Capital Region of Denmark, Nordre Ringvej 57, building 84-85, 2600, Glostrup, Denmark.Glostrup Research Institute, Department of Clinical Experimental Research, Glostrup, DanmarkDanmark
  • Ulla Toft
  • Kim Overvad
  • Jytte Halkjær
    Jytte HalkjærDanish Cancer Society Research Center, Strandboulevarden 49, Copenhagen 2100, Denmark.Danmark
  • Anne Tjønneland
    Anne TjønnelandDanish Cancer Society Research Center, Strandboulevarden 49, Copenhagen 2100, Denmark.Danmark
  • Torben Hansen
  • Oluf Pedersen
    Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research (Section of Metabolic Genetics), and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Alle 20, 2200, Copenhagen N, Denmark.
  • Thorkild I A Sørensen
    Thorkild I A SørensenMRC Integrative Epidemiology Unit, Bristol University, Senate House, Tyndall Avenue, Bristol, BS8 1TH, UK.Department of Clinical Epidemiology (Formerly 'Institute of Preventive Medicine'), Bispebjerg and Frederiksberg Hospital, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, first floor, 2000, Frederiksberg, Denmark.The Novo Nordisk Foundation Center for Basic Metabolic Research (Section of Metabolic Genetics), and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Alle 20, 2200, Copenhagen N, Denmark.Danmark
  • Berit L Heitmann

BACKGROUND: Studies have suggested a link between alcohol intake and adiposity. However, results from longitudinal studies have been inconsistent, and a possible interaction with genetic predisposition to adiposity measures has often not been taken into account.

OBJECTIVE: To examine the association between alcohol intake recorded at baseline and subsequent annual changes in body weight (∆BW), waist circumference (ΔWC) and WC adjusted for BMI (ΔWCBMI), and to test for interaction with genetic predisposition scores based on single nucleotide polymorphisms (SNPs) associated with various forms of adiposity.

METHOD: This study included a total of 7028 adult men and women from MONICA, the Diet, Cancer and Health cohort (DCH), and the Inter99 studies. We combined 50 adiposity-associated SNPs into four scores indicating genetic predisposition to BMI, WC, WHRBMI and all three traits combined. Linear regression was used to examine the association of alcohol intake (drinks of 12 g (g) alcohol/day) with ΔBW, ΔWC, and ΔWCBMI, and to examine possible interactions with SNP-scores. Results from the analyses of the individual cohorts were combined in meta-analyses.

RESULTS: Each additional drink/day was associated with a ΔBW/year of -18.0 g (95% confidence interval (CI): -33.4, -2.6, P = 0.02) and a ΔWC of -0.3 mm/year (-0.5, -0.0, P = 0.03). In analyses of women only, alcohol intake was associated with a higher ΔWCBMI of 0.5 mm/year (0.2, 0.9, P = 0.002) per drink/day. Overall, we found no statistically significant interactions between the four SNP-scores and alcohol intake in relation to changes in adiposity measures. However in analyses of women separately, we found interaction between the complete score of all 50 SNPs and alcohol intake in relation to ΔBW (P for interaction = 0.03). No significant interaction was observed among the men.

CONCLUSION: Alcohol intake was associated with a decrease in BW and WC among men and women, and an increase in WCBMI among women only. We found no strong indication that these associations depend on a genetic predisposition to adiposity.

TRIAL REGISTRATION: Registry: ClinicalTrials.gov Trial number: CT00289237 , Registered: 19 September 2005 retrospectively registered.

OriginalsprogEngelsk
TidsskriftNutrition Journal
Vol/bind16
Tidsskriftsnummer1
Sider (fra-til)51
ISSN1475-2891
DOI
StatusUdgivet - 25 aug. 2017

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