Biomarkers in patients with Chronic Obstructive Pulmonary Disease in general practice: A prospective cohort study

Publikation: Forskning - peer reviewKonferenceabstrakt til konference

  • Frans Boch Waldorff
    Frans Boch WaldorffSyddansk UniversitetDanmark
  • Anders Halling
    Anders HallingCenter for Primary Health Care Research, Lund UniversitySverige
  • Loni Kraus Ledderer
  • Mette Reilev
    Mette ReilevSyddansk UniversitetDanmark
  • Heidi Gram
    Heidi GramSyddansk UniversitetDanmark
  • Dorte E Jarbøl
    Dorte E JarbølForskningsenheden for Almen Praksis, Syddansk UniversitetDanmark
  • Jesper Lykkegaard
    Jesper LykkegaardForskningsenheden for Almen PraksisDanmark
  • Jens Soendergaard
    Jens SoendergaardForskningsenheden for Almen Praksis, Syddansk UniversitetDanmark
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a common chronic disease primarily treated in primary care. It is a complex and heterogeneous disease and the trajectory is difficult to predict. The overall aim of this study is to investigate predictors of the trajectory of COPD treated in primary care and to determine the added value of selected biomarkers such as microfibrillar-associated protein 4 (MFAP4) and surfactant protein D (SP-D).
Methods: Prospective cohort study comprising COPD patients. A total of 38 Danish practices were included in the study. Criteria for inclusion were a diagnosis of COPD (ICPC code R95-), age ≥ 40 years, Danish language speaking, no severe psychiatric or cognitive disease and ability to visit the GP surgery. Prevalent as well as incident patients diagnosed with COPD were eligible. Baseline data included a patient questionnaire and validated questionnaires regarding respiration, activity of daily living, depression and fatigue. Further, clinical indicators of the patient’s COPD status were obtained ad well as blood samples for biomarkers. End points will include rates of exacerbations, hospitalizations, deaths and decline in lung function.
Results: We included 634 patients of whom 52% are females. The mean age of the study population is 68.1 years. Additional baseline characteristics and preliminary results will be presented at the congress.
In this study we explore determinants of trajectory for COPD in primary care and the added value of selected biomarkers.
Udgivelsesår15 jun. 2017
Antal sider1
StatusUdgivet - 15 jun. 2017
BegivenhedNordic Congress of General Practice - The Venue – Harpan, Reykjavik, Island
Varighed: 14 jun. 201716 jun. 2017


KonferenceNordic Congress of General Practice
LokationThe Venue – Harpan


  • COPD, biomarker

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