Fibre intake and the development of inflammatory bowel disease: A European prospective multi-centre cohort study (EPIC-IBD)

Publikation: Forskning - peer reviewTidsskriftartikel

DOI

  • Vibeke Andersen
    Vibeke AndersenFocused Research Unit for Molecular Diagnostic and Clinical Research, IRS-Center Soenderjylland, Laboratory Center, Hospital of Southern Jutland, Aabenraa, Denmark.Institute of Regional Health Research-Center Soenderjylland, University of Southern Denmark , Odense DK-5230, Denmark.3 Institute of Molecular Medicine, University of Southern Denmark, Denmark.
  • Simon Chan
    Simon ChanDepartment of Medicine, Norwich Medical School University of East Anglia, Norwich, UK; Norfolk & Norwich University Hospitals NHS Trust, Norwich, UK.Storbritannien
  • Robert Luben
    Robert LubenStrangeways Research Laboratory, Institute of Public Health, University of Cambridge, Cambridge, UK.Storbritannien
  • Kay-Tee Khaw
    Kay-Tee KhawStrangeways Research Laboratory, Institute of Public Health, University of Cambridge, Cambridge, UK.Storbritannien
  • Anja Olsen
    Anja OlsenDanish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.Danmark
  • Anne Tjonneland
    Anne TjonnelandDanish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.Danmark
  • R Kaaks
    R KaaksDivision of Clinical Epidemiology, DKFZ-German Cancer Research Centre, Heidelberg, Germany.Tyskland
  • Olof Grip
    Olof GripDepartment of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, Malmö, Sweden.Sverige
  • M M Bergmann
    M M BergmannDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.Tyskland
  • H Boeing
    H BoeingDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.Tyskland
  • Johan Hultdin
    Johan HultdinDepartment of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, SwedenSverige
  • Pontus Karling
    Pontus Karling7Occupational and Environmental Medicine,Department of Public Health and Clinical Medicine,Umeå University,Umeå,Sweden.Sverige
  • Kim Overvad
  • Bas Oldenburg
    Bas OldenburgDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands.Holland
  • Jorrit Opstelten
    Jorrit OpsteltenDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands.Holland
  • Marie-Christine Boutron-Ruault
    Marie-Christine Boutron-RuaultUniversité Paris Sud, UMRS 1018, F-94805, Villejuif , France Frankrig
  • Franck Carbonnel
    Franck CarbonnelDepartment of Gastroenterology, Bicetre University Hospital, Assistance Publique des Hopitaux, France.Frankrig
  • Antoine Racine
    Antoine RacineDepartment of Gastroenterology, Bicetre University Hospital, Assistance Publique des Hopitaux, France.Frankrig
  • Timothy Key
    Timothy KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.Storbritannien
  • Giovanna Masala
    Giovanna MasalaCancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.Italien
  • Domenico Palli
    Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.Italien
  • R Tumino
    R TuminoCancer Registry and Histopathology Department, 'Civic - M.P.Arezzo' Hospital, Italy.Italien
  • A Trichopoulou
    A TrichopoulouWHO Collaborating Centre for Food and Nutrition Polices, Greece.Grækenland
  • Elio Riboli
    Elio RiboliDivision of Epidemiology, Imperial College London, London, UK.Storbritannien
  • Andrew Hart
    Andrew HartDepartment of Medicine, Norwich Medical School University of East Anglia, Norwich, UK; Norfolk & Norwich University Hospitals NHS Trust, Norwich, UK.Storbritannien

Background and Aims: Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between fibre intake and the development of Crohn's disease [CD] and ulcerative colitis [UC] in a large European population.

Methods: In total, 401326 participants, aged 20-80 years, were recruited in eight countries in Europe between 1991 and 1998. At baseline, fibre intake [total fibres, fibres from fruit, vegetables and cereals] was recorded using food frequency questionnaires. The cohort was monitored for the development of inflammatory bowel disease. Each case was matched with four controls and odds ratios [ORs] for the exposures were calculated using conditional logistic regression. Sensitivity analyses according to smoking status were computed.

Results: In total, 104 and 221 participants developed incident CD and UC, respectively. For both CD and UC, there were no statistically significant associations with either quartiles, or trends across quartiles, for total fibre or any of the individual sources. The associations were not affected by adjusting for smoking and energy intake. Stratification according to smoking status showed null findings apart from an inverse association with cereal fibre and CD in non-smokers [Quartile 4 vs 1 OR = 0.12, 95% confidence interval = 0.02-0.75, p = 0.023, OR trend across quartiles = 0.50, 95% confidence interval = 0.29-0.86, p = 0.017].

Conclusion: The results do not support the hypothesis that dietary fibre is involved in the aetiology of UC, although future work should investigate whether there may be a protective effect of specific types of fibre according to smoking status in CD.

OriginalsprogEngelsk
TidsskriftJournal of Crohn's & colitis
Vol/bind12
Tidsskriftsnummer2
Sider (fra-til)129-136
Antal sider8
ISSN1873-9946
DOI
StatusUdgivet - 24 jan. 2018

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