Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study

Publikation: Forskning - peer reviewTidsskriftartikel

DOI

  • Karina Meidtner
    Karina MeidtnerGerman Center for Diabetes Research (DZD), Düsseldorf, Germany.Tyskland
  • Clara Podmore
    Clara PodmoreMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, U.K.Storbritannien
  • Janine Kröger
    Janine KrögerDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.Tyskland
  • Yvonne T van der Schouw
    Yvonne T van der SchouwUniversity Medical Center Utrecht, Utrecht, The Netherlands.Holland
  • Benedetta Bendinelli
    Benedetta BendinelliCancer Research and Prevention Institute (ISPO), Florence, Italy.Italien
  • Claudia Agnoli
    Claudia AgnoliEpidemiology and Prevention Unit, Milan, Italy.Italien
  • Larraitz Arriola
    Larraitz ArriolaConsorcio Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.Spanien
  • Aurelio Barricarte
    Aurelio BarricarteIdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
  • Heiner Boeing
    Heiner BoeingGerman Institute of Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany.Tyskland
  • Amanda J Cross
    Amanda J CrossDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, U.K.Storbritannien
  • Courtney Dow
    Courtney DowDepartment of Radiation Oncology, Gustave Roussy Cancer Institute, Villejuif, France.Frankrig
  • Kim Ekblom
    Kim EkblomDepartment of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, SwedenSverige
  • Guy Fagherazzi
    Guy FagherazziDepartment of Radiation Oncology, Gustave Roussy Cancer Institute, Villejuif, France.Frankrig
  • Paul W Franks
    Paul W Franks7Occupational and Environmental Medicine,Department of Public Health and Clinical Medicine,Umeå University,Umeå,Sweden.Sverige
  • Marc J Gunter
    Marc J GunterInternational Agency for Research on Cancer, 69008 Lyon, France.Frankrig
  • José María Huerta
    José María HuertaDepartment of Epidemiology, Murcia Regional Health Council, Instituto Murciano de Investigación Biosanitaria-Arrixaca, Murcia, Spain.Spanien
  • Paula Jakszyn
    Paula JakszynBlanquerna Health Sciences Faculty, Universidad Ramon Llull, Barcelona, Spain.Spanien
  • Mazda Jenab
    Mazda JenabInternational Agency for Research on Cancer, 69008 Lyon, France.Frankrig
  • Verena A Katzke
    Verena A KatzkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.Tyskland
  • Timothy J Key
    Timothy J KeyUniversity of Oxford, Oxford, U.K.Storbritannien
  • Kay Tee Khaw
    Kay Tee KhawDepartment of Paediatrics, University of Cambridge, Cambridge, U.K.Storbritannien
  • Tilman Kühn
    Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.Tyskland
  • Cecilie Kyrø
    Cecilie KyrøDanish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.Danmark
  • Francesca Romana Mancini
    Francesca Romana ManciniDepartment of Radiation Oncology, Gustave Roussy Cancer Institute, Villejuif, France.Frankrig
  • Olle Melander
    Olle MelanderDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.Sverige
  • Peter M Nilsson
    Peter M NilssonDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.Sverige
  • Kim Overvad
  • Domenico Palli
    Domenico PalliCancer Research and Prevention Institute (ISPO), Florence, Italy.Italien
  • Salvatore Panico
    Salvatore PanicoDipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Federico II University, Naples, Italy.Italien
  • J Ramón Quirós
    J Ramón QuirósPublic Health Directorate, Asturias, Spain.Spanien
  • Miguel Rodriguez-Barranco
    Miguel Rodriguez-BarrancoEscuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, 18014 Granada, Spain.Spanien
  • Carlotta Sacerdote
    Carlotta SacerdoteCenter for Cancer Prevention, Torino, Italy Human Genetics Foundation (HuGeF), Torino, Italy.Italien
  • Ivonne Sluijs
    Ivonne SluijsUniversity Medical Center Utrecht, Utrecht, The Netherlands.Holland
  • Magdalena Stepien
    Magdalena StepienInternational Agency for Research on Cancer, 69008 Lyon, France.Frankrig
  • Anne Tjonneland
    Anne TjonnelandDanish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.Danmark
  • Rosario Tumino
    Rosario TuminoL'Associazione Iblea per la Ricerca Epidemiologica- Organizazione Non Lucrativa di Utilità Sociale, Ragusa, Italy.Italien
  • Nita G Forouhi
    Nita G ForouhiMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, U.K.Storbritannien
  • Stephen J Sharp
    Stephen J SharpMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, U.K.Storbritannien
  • Claudia Langenberg
    Claudia LangenbergMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, U.K.Storbritannien
  • Matthias B Schulze
    Matthias B SchulzeGerman Center for Diabetes Research (DZD), Düsseldorf, Germany.Tyskland
  • Elio Riboli
    Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, U.K.Storbritannien
  • Nicholas J Wareham
    Nicholas J WarehamMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, U.K.Storbritannien

OBJECTIVE: Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes.

RESEARCH DESIGN AND METHODS: The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression.

RESULTS: Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (β = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (-0.019 [-0.043; 0.006]) or transferrin saturation (0.016 [-0.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6 V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (Padd = 0.16, Pmult = 0.21) but did detect a trend toward a negative interaction in men (Padd = 0.04, Pmult = 0.03).

CONCLUSIONS: We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.

OriginalsprogEngelsk
TidsskriftDiabetes care
Vol/bind41
Tidsskriftsnummer2
Sider (fra-til)277-285
Antal sider9
ISSN0149-5992
DOI
StatusUdgivet - feb. 2018

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