Chaotic Dynamics Mediates Brain State Transitions, Driven by Changes in Extracellular Ion Concentrations

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  • Rune Rasmussen
  • Mogens H. Jensen, Niels Bohr Institutet, DanmarkMathias L. Heltberg, Niels Bohr Institutet, Danmark
Previous studies have suggested that changes in extracellular ion concentrations initiate the transition from an activity state that characterizes sleep in cortical neurons to states that characterize wakeful- ness. However, because neuronal activity and extra- cellular ion concentrations are interdependent, isolating their unique roles during sleep-wake transitions is not possible in vivo. Here, we extend the Averaged-Neuron model and demonstrate that, although changes in extracellular ion concentrations occur concurrently, decreasing the conductance of calcium-dependent potassium channels initiates the transition from sleep to wakefulness. We find that sleep is governed by stable, self-sustained oscillations in neuronal firing patterns, whereas the quiet awake state and active awake state are both governed by irregular oscillations and chaotic dynamics; transitions between these separable awake states are prompted by ionic changes. Although waking is indicative of a shift from stable to chaotic neuronal firing patterns, we illustrate that the properties of chaotic dynamics ensure that the transition between states is smooth and robust to noise.
OriginalsprogEngelsk
Artikelnummer10.1016/j.cels.2017.11.011
TidsskriftCell Systems
Vol/bind5
Tidsskriftsnummer6
Sider (fra-til)1-13
Antal sider13
ISSN2405-4712
DOI
StatusUdgivet - 13 dec. 2017

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