Adolescent Diet Quality and Cardiovascular Disease Risk Factors and Incident Cardiovascular Disease in Middle-Aged Women

Publikation: Forskning - peer reviewTidsskriftartikel

DOI

  • Christina C Dahm
  • Andrea K Chomistek
    Andrea K ChomistekDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN.
  • Marianne Uhre Jakobsen
  • Kenneth J Mukamal
    Kenneth J MukamalDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
  • A Heather Eliassen
    A Heather EliassenFrom Department of Sports Science and Clinical Biomechanics, Research Unit for Exercise Epidemiology, University of Southern Denmark, Campusvej (K.B., M.R.G., L.Ø., A.G.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (M.K.J.); Department of Medicine, Channing Division of Network Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA (M.K.J.); Department of Cardiology, Aalborg University Hospital, Denmark (K.O.); Department of Public Health, Section for Epidemiology, Aarhus University, Denmark (K.O.); and Danish Cancer Society Research Center, Copenhagen, Denmark (A.T.). agroentved@health.sdu.dk.
  • Howard D Sesso
    Howard D SessoFrom Department of Sports Science and Clinical Biomechanics, Research Unit for Exercise Epidemiology, University of Southern Denmark, Campusvej (K.B., M.R.G., L.Ø., A.G.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (M.K.J.); Department of Medicine, Channing Division of Network Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA (M.K.J.); Department of Cardiology, Aalborg University Hospital, Denmark (K.O.); Department of Public Health, Section for Epidemiology, Aarhus University, Denmark (K.O.); and Danish Cancer Society Research Center, Copenhagen, Denmark (A.T.). agroentved@health.sdu.dk.
  • Kim Overvad
  • Walter C Willett
    Walter C WillettDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
  • Eric B Rimm
    Eric B RimmDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
  • Stephanie E Chiuve
    Stephanie E ChiuveDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

BACKGROUND: Primary prevention of cardiovascular disease (CVD) focuses on treatment of risk factors, including hypercholesterolemia, hypertension, and type 2 diabetes mellitus. We investigated whether a healthy diet in adolescence prevents development of clinical risk factors or incidence of CVD in adulthood.

METHODS AND RESULTS: We examined the time to the first development of ≥1 clinical risk factor (hypercholesterolemia, hypertension, or type 2 diabetes mellitus) or CVD in relation to a high school Alternative Healthy Eating Index (HS-AHEI) within the Nurses' Health Study II. Among those who completed a food frequency questionnaire about their high school diet and adult diet (mean age 42 years), 27 406 women free of clinical risk factors and 42 112 women free of CVD in 1998 were followed to June 2011. Hazard ratios (HRs) and 95% CIs were adjusted for potential confounders in high school and adulthood. We documented 11 542 first diagnoses of clinical risk factors and 423 CVD events. The HS-AHEI was associated with a lower rate of risk factors (HR highest versus lowest quintiles 0.82; 95% CI, 0.77-0.87 [P trend <0.001]), was inversely associated with risk of developing ≥1 clinical risk factor in women with a low, medium, and high AHEI score during adulthood (HR high HS-AHEI/high adult AHEI versus low/low 0.79 [95% CI, 0.74-0.85]), but was not statistically significantly associated with incident CVD.

CONCLUSIONS: A healthy diet during adolescence is associated with lower risk of developing CVD risk factors. As diet tracks throughout life, and adult diet prevents CVD, healthy dietary habits that begin early are important for primordial prevention of CVD.

OriginalsprogEngelsk
TidsskriftJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Vol/bind5
Tidsskriftsnummer12
ISSN2047-9980
DOI
StatusUdgivet - 20 dec. 2016

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