Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

Publikation: Forskning - peer reviewTidsskriftartikel

DOI

  • Peter K Joshi
    Peter K JoshiCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK. peter.joshi@ed.ac.uk.
  • Nicola Pirastu
    Nicola PirastuCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
  • Katherine A Kentistou
    Katherine A KentistouCentre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland.
  • Krista Fischer
    Krista FischerEstonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
  • Edith Hofer
    Edith HoferInstitute of Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, 8036, Austria.
  • Katharina E Schraut
    Katharina E SchrautCentre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland.
  • David W Clark
    David W ClarkCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
  • Teresa Nutile
    Teresa NutileInstitute of Genetics and Biophysics "A. Buzzati-Traverso" - CNR, Naples, 80131, Italy.
  • Catriona L K Barnes
    Catriona L K BarnesCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
  • Paul R H J Timmers
    Paul R H J TimmersCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
  • Xia Shen
    Xia ShenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
  • Ilaria Gandin
    Ilaria GandinInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
  • Aaron F McDaid
    Aaron F McDaid1] Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland. [2] Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.
  • Thomas Folkmann Hansen
    Thomas Folkmann HansenInstitute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen, Roskilde, DK-4000, Denmark.The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Risskov, Denmark ; Department of Biomedicine and Centre for Integrative Sequencing, iSEQ, University of Aarhus, Aarhus C, 8000 Denmark.
  • Scott D Gordon
    Scott D GordonGenetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, QLD, 4006, Australia.
  • Franco Giulianini
    Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
  • Thibaud S Boutin
    Thibaud S BoutinMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
  • Abdel Abdellaoui
    Abdel AbdellaouiNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH), Amsterdam, 1081BT, Netherlands.
  • Wei Zhao
    Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Carolina Medina-Gomez
    Carolina Medina-GomezDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Traci M Bartz
    Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, 98101, USA.
  • Stella Trompet
    Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
  • Leslie A Lange
    Leslie A LangeDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, 80045, USA.
  • Laura Raffield
    Laura RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA.
  • Ashley van der Spek
    Ashley van der SpekDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Tessel E Galesloot
    Tessel E GaleslootDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, 6500 HB, The Netherlands.
  • Petroula Proitsi
    Petroula ProitsiMRC Unit for Lifelong Health & Ageing at UCL, University College London, London, WC1B 5JU, UK.
  • Lisa R Yanek
    Lisa R YanekDepartment of Medicine, GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Lawrence F Bielak
    Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Antony Payton
    Antony PaytonCentre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, The University of Manchester, Manchester, Greater, Manchester, M13 9PL, UK.
  • Federico Murgia
    Federico MurgiaCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, 39100, Italy.
  • Maria Pina Concas
    Maria Pina ConcasInstitute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy, Sassari, 07100, Italy.
  • Ginevra Biino
    Ginevra BiinoInstitute of Molecular Genetics, National Research Council of Italy, Pavia, 27100, Italy.
  • Salman M Tajuddin
    Salman M TajuddinLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, MD, 21224, USA.
  • Ilkka Seppälä
    Ilkka SeppäläDepartment of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
  • Najaf Amin
    Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Eric Boerwinkle
    Eric BoerwinkleHealth Science Center at Houston, UTHealth School of Public Health, University of Texas, Houston, TX, 77030, USA.
  • Anders D Børglum
  • Archie Campbell
    Archie CampbellCentre for Genomic & Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Ellen W Demerath
    Ellen W DemerathDivision of Epidemiology &Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA.
  • Ilja Demuth
    Ilja DemuthInstitute for Medical and Human Genetics, Charité, Universitätsmedizin Berlin, Berlin, 13353, Germany.
  • Jessica D Faul
    Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48014, USA.
  • Ian Ford
    Ian FordRobertson Center for biostatistics, University of Glasgow, Glasgow, G12 8QQ, UK.
  • Alessandro Gialluisi
    Alessandro GialluisiIRCCS Neuromed, Pozzilli (IS), 86077, Italy.
  • Martin Gögele
    Martin GögeleCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, 39100, Italy.
  • MariaElisa Graff
    MariaElisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
  • Aroon Hingorani
    Aroon HingoraniInstitute of Cardiovascular Science, University College London, London, WC1E 6BT, UK.
  • Jouke-Jan Hottenga
    Jouke-Jan HottengaNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH), Amsterdam, 1081BT, Netherlands.
  • David M Hougaard
    David M HougaardCenter for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, 2300, Denmark.
  • Mikko A Hurme
    Mikko A HurmeDepartment of Microbiology and Immunology, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
  • M Arfan Ikram
    M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Marja Jylhä
    Marja JylhäGerontology Research Center, Tampere, Finland, Faculty of Social Sciences, University of Tampere, Tampere, 33104, Finland.
  • Diana Kuh
    Diana KuhMRC Unit for Lifelong Health & Ageing at UCL, University College London, London, WC1B 5JU, UK.
  • Lannie Ligthart
    Lannie LigthartNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH), Amsterdam, 1081BT, Netherlands.
  • Christina M Lill
    Christina M LillGenetic and Molecular Epidemiology Group, Institute of Neurogenetics, University of Lübeck, 23562, Lübeck, Germany.
  • Ulman Lindenberger
    Ulman LindenbergerMax Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, 14195, Germany.
  • Thomas Lumley
    Thomas LumleyDepartment of Statistics, University of Auckland, Auckland, 1010, New Zealand.
  • Reedik Mägi
    Reedik MägiEstonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
  • Pedro Marques-Vidal
    Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, 1011, Switzerland.
  • Sarah E Medland
    Sarah E MedlandGenetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, QLD, 4006, Australia.
  • Lili Milani
    Lili MilaniEstonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
  • Reka Nagy
    Reka NagyMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
  • William E R Ollier
    William E R OllierDivision of Population Health, Health Services Research & Primary Care, School of Health Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, Greater Manchester, M13 9PL, UK.
  • Patricia A Peyser
    Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Peter P Pramstaller
    Peter P PramstallerCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, 39100, Italy.
  • Paul M Ridker
    Paul M RidkerTH Chan School of Public Health, Harvard Medical School, Boston, MA, 02115, USA.
  • Fernando Rivadeneira
    Fernando RivadeneiraDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Daniela Ruggiero
    Daniela RuggieroInstitute of Genetics and Biophysics "A. Buzzati-Traverso" - CNR, Naples, 80131, Italy.
  • Yasaman Saba
    Yasaman SabaAustrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8010, Austria.
  • Reinhold Schmidt
    Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
  • Helena Schmidt
    Helena SchmidtAustrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8010, Austria.
  • P Eline Slagboom
    P Eline SlagboomSection of Molecular Epidemiology, Department of medical statistics, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
  • Blair H Smith
    Blair H SmithDivision of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
  • Jennifer A Smith
    Jennifer A SmithSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48014, USA.
  • Nona Sotoodehnia
    Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, 98101, USA.
  • Elisabeth Steinhagen-Thiessen
    Elisabeth Steinhagen-ThiessenCharité Research Group on Geriatrics, Charité, Universitätsmedizin Berlin, Berlin, 13347, Germany.
  • Frank J A van Rooij
    Frank J A van RooijDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • André L Verbeek
    André L VerbeekDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, 6500 HB, The Netherlands.
  • Sita H Vermeulen
    Sita H VermeulenDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, 6500 HB, The Netherlands.
  • Peter Vollenweider
    Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, 1011, Switzerland.
  • Yunpeng Wang
    Yunpeng WangNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, 0450, Norway.
  • Thomas Werge
    Thomas WergeThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Risskov, Denmark ; Department of Biomedicine and Centre for Integrative Sequencing, iSEQ, University of Aarhus, Aarhus C, 8000 Denmark.
  • John B Whitfield
    John B WhitfieldGenetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, QLD, 4006, Australia.
  • Alan B Zonderman
    Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, MD, 21224, USA.
  • Terho Lehtimäki
    Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
  • Michele K Evans
    Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, MD, 21224, USA.
  • Mario Pirastu
    Mario PirastuInstitute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy, Sassari, 07100, Italy.
  • Christian Fuchsberger
    Christian FuchsbergerCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, 39100, Italy.
  • Lars Bertram
    Lars BertramNeuroepidemiology and Ageing Research Group, School of Public Health, Imperial College, London, W6 8RP, UK.
  • Neil Pendleton
    Neil PendletonDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, Greater Manchester, M13 9PL, UK.
  • Sharon L R Kardia
    Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Marina Ciullo
    Marina CiulloIRCCS Neuromed, Pozzilli (IS), 86077, Italy.
  • Diane M Becker
    Diane M BeckerDepartment of Medicine, GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Andrew Wong
    Andrew WongMRC Unit for Lifelong Health & Ageing at UCL, University College London, London, WC1B 5JU, UK.
  • Bruce M Psaty
    Bruce M PsatyKaiser Permanente Washington Health Research Institute, Seattle, WA, 98101, USA.
  • Cornelia M van Duijn
    Cornelia M van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • James G Wilson
    James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
  • J Wouter Jukema
    J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
  • Lambertus Kiemeney
    Lambertus KiemeneyDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, 6500 HB, The Netherlands.
  • André G Uitterlinden
    André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Nora Franceschini
    Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
  • Kari E North
    Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
  • David R Weir
    David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48014, USA.
  • Andres Metspalu
    Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
  • Dorret I Boomsma
    Dorret I BoomsmaNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH), Amsterdam, 1081BT, Netherlands.
  • Caroline Hayward
    Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
  • Daniel Chasman
    Daniel ChasmanTH Chan School of Public Health, Harvard Medical School, Boston, MA, 02115, USA.
  • Nicholas G Martin
    Nicholas G MartinGenetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, QLD, 4006, Australia.
  • Naveed Sattar
    Naveed SattarBHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TD, UK.
  • Harry Campbell
    Harry CampbellCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
  • Tōnu Esko
    Tōnu Esko1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Finland. [2] Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA. [4] Psychiatric &Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
  • Zoltán Kutalik
    Zoltán Kutalik1] Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland. [2] Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.
  • James F Wilson
    James F WilsonMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
OriginalsprogEngelsk
TidsskriftNature Communications
Vol/bind8
Tidsskriftsnummer1
Sider (fra-til)910
ISSN2041-1723
DOI
StatusUdgivet - 13 okt. 2017

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