Chocolate intake and risk of clinically apparent atrial fibrillation: the Danish Diet, Cancer, and Health Study

Publikation: Forskning - peer reviewTidsskriftartikel


  • Elizabeth Mostofsky
    Elizabeth MostofskyDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.USA
  • Martin Berg Johansen
    Martin Berg JohansenDepartment of Cardiology, Aalborg University Hospital, Aalborg, Aalborg, Denmark.Unit for Clinical Biostatistics and Bioinformatics, Aalborg University Hospital, Aalborg, Denmark.
  • Anne Tjønneland
    Anne TjønnelandInstitute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.Danmark
  • Harpreet S Chahal
    Harpreet S ChahalDepartment of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.Canada
  • Murray A Mittleman
    Murray A MittlemanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.USA
  • Kim Overvad

OBJECTIVE: To evaluate the association between chocolate intake and incident clinically apparent atrial fibrillation or flutter (AF).

METHODS: The Danish Diet, Cancer, and Health Study is a large population-based prospective cohort study. The present study is based on 55 502 participants (26 400 men and 29 102 women) aged 50-64 years who had provided information on chocolate intake at baseline. Incident cases of AF were ascertained by linkage with nationwide registries.

RESULTS: During a median of 13.5 years there were 3346 cases of AF. Compared with chocolate intake less than once per month, the rate of AF was lower for people consuming 1-3 servings/month (hazard ratio (HR) 0.90, 95% confidence interval (CI) 0.82 to 0.98), 1 serving/week (HR 0.83, 95% CI 0.74 to 0.92), 2-6 servings/week (HR 0.80, 95% CI 0.71 to 0.91) and ≥1 servings/day (HR 0.84, 95% CI 0.65 to 1.09; p-linear trend <0.0001), with similar results for men and women.

CONCLUSIONS: Accumulating evidence indicates that moderate chocolate intake may be inversely associated with AF risk, although residual confounding cannot be ruled out.

Sider (fra-til)1163-1167
Antal sider5
StatusUdgivet - aug. 2017

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