Environmental variation partitioned into separate heritable components

Publikation: Forskning - peer reviewTidsskriftartikel

DOI

  • Michael Ørsted
    Michael ØrstedSection of Biology and Environmental Science, Department of Chemistry and Bioscience, Aalborg UniversityDanmark
  • Palle Duun Rohde
  • Ary A Hoffmann
    Ary A HoffmannSchool of Biosciences, Bio21 Molecular Science and Biotechnology Institute, The University of MelbourneAustralien
  • Peter Sørensen
  • Torsten Nygård Kristensen
Trait variation is normally separated into genetic and environmental components, yet genetic factors also control the expression of environmental variation, encompassing plasticity across environmental gradients and within-environment responses. We defined four components of environmental variation: plasticity across environments, variability in plasticity, variation within environments, and differences in within-environment variation across environments. We assessed these components for cold tolerance across five rearing temperatures using the Drosophila melanogaster Genetic Reference Panel (DGRP). The four components were found to be heritable, and genetically correlated to different extents. By whole genome single marker regression, we detected multiple candidate genes controlling the four components and showed limited overlap in genes affecting them. Using the binary UAS- GAL4 system, we functionally validated the effects of a subset of candidate genes affecting each of the four components of environmental variation and also confirmed the genetic and phenotypic correlations obtained from the DGRP in distinct genetic backgrounds. We delineate selection targets associated with environmental variation and the constraints acting upon them, providing a framework for evolutionary and applied studies on environmental sensitivity. Based on our results we suggest that the traditional quantitative genetic view of environmental variation and genotype-by-environment interactions needs revisiting.
OriginalsprogEngelsk
TidsskriftEvolution
Vol/bind72
Tidsskriftsnummer1
Sider (fra-til)136-152
Antal sider17
ISSN0014-3820
DOI
StatusUdgivet - jan. 2018

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