Microsomal drug-metabolizing enzymes in the olive baboon (papio anabis).

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskning

  • Herman Autrup
  • Brenda J. Thurlow, Department of Pathology, Medical School, University of Nairobi, Nairobi, Chester Beatty Institute, Institute of Cancer Research, Royal Cancer Hospital, London, KenyaJohnston Wakhisi, Department of Pathology, Medical School, University of Nairobi, Nairobi, KenyaGerald P. Warwick, Department of Pathology, Medical School, University of Nairobi, Nairobi, Chester Beatty Institute, Institute of Cancer Research, Royal Cancer Hospital, London, Kenya
  • Afdeling for Miljø- og Arbejdsmedicin
1.1. The activity of microsomal drug-metabolizing enzymes—azo reductase, nitroreductase, p-hydroxylation, N-demethylation, O-demethylation, NADPH cytochrome c reductase and cytochrome P P-450—in the olive baboon are lower than in other animal species, e.g. mouse, rat, guinea-pig.
2. 2. The level is comparable with the level in man for N-demethylation, azo reductase, O-demethylation and NADPH cytochrome c reductase.
3. 3. The ratio of the activity of the p-hydroxylation as compared with cytochrome P-450 is very similar in baboon and man.
4. 4. Arylsulfatase is localized in the lysosomal fraction and beta-glucuronidase is present more in the lysosomal than in the microsomal fraction.
OriginalsprogEngelsk
TidsskriftComparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology
Vol/bind50
Tidsskriftsnummer3
Sider (fra-til)385-390
Antal sider6
ISSN1096-4959
DOI
StatusUdgivet - 15 mar. 1975

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