Pulmonary artery wave propagation and reservoir function in conscious man: impact of pulmonary vascular disease, respiration and dynamic stress tests

Publikation: Forskning - peer reviewTidsskriftartikel

  • Junjing Su
  • Charlotte Manisty
    Charlotte Manisty
  • Ulf Simonsen
  • Luke Howard
    Luke HowardDanmark
  • Kim H Parker
    Kim H Parker
  • Alun D Hughes
    Alun D HughesInstitute of Cardiovascular Science, University College LondonStorbritannien
Detailed haemodynamic analysis may provide novel insights into the pulmonary circulation. Therefore, wave intensity and reservoir-excess pressure analyses were applied in the pulmonary artery to characterize changes in wave propagation and reservoir function during spontaneous respiration and dynamic stress tests. Right heart catheterization was performed using a pressure and Doppler flow sensor tipped guidewire to obtain simultaneous pressure and flow velocity measurements in the pulmonary artery in control subjects and patients with pulmonary arterial hypertension (PAH) at rest. In controls, recordings were also obtained during Valsalva manoeuvre and handgrip exercise. The asymptotic pressure at which the flow through the microcirculation ceases, the reservoir pressure related to arterial compliance and the excess pressure caused by arterial waves increased in PAH patients compared to controls. The systolic and diastolic rate constants also increased, while the diastolic time constant decreased. The forward compression wave energy decreased by ∼8% in controls and ∼6% in PAH patients during expiration compared to inspiration, while the wave speed remained unchanged throughout the respiratory cycle. Wave energy decreased during Valsalva manoeuvre (by ∼45%) and handgrip exercise (by ∼27%) with unaffected wave speed. Moreover, the reservoir and excess pressures decreased during Valsalva manoeuvre but remained unaltered during handgrip exercise. In conclusion, reservoir-excess pressure analysis applied to the pulmonary artery revealed distinctive differences between controls and PAH patients. Variations in the ventricular preload and afterload influence pulmonary arterial wave propagation as demonstrated by changes in wave energy during spontaneous respiration and dynamic stress tests.
OriginalsprogEngelsk
TidsskriftThe Journal of Physiology
Vol/bind595
Tidsskriftsnummer20
Sider (fra-til)6463
Antal sider6.476
ISSN0022-3751
StatusUdgivet - 15 okt. 2017

Se relationer på Aarhus Universitet Citationsformater

ID: 119028546