Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations: A Nested Case-Control Study

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    Jorrit L Opstelten, Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands., HollandSimon S M Chan, Department of Gastroenterology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom., StorbritannienAndrew R Hart, Department of Gastroenterology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom., StorbritannienFiona D M van Schaik, Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands., HollandPeter D Siersema, Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands., HollandEef G W M Lentjes, Department of Clinical Chemistry and Hematology, University Medical Center, Utrecht, the Netherlands., HollandKay-Tee Khaw, Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom., StorbritannienRobert Luben, Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom., StorbritannienTimothy J Key, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., StorbritannienHeiner Boeing, Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany., TysklandManuela M Bergmann, Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany., Tyskland
  • Kim Overvad
  • Domenico Palli, Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy., ItalienGiovanna Masala, Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy., ItalienAntoine Racine, Department of Gastroenterology, University Hospital of Bicêtre, Assistance Publique - Hôpitaux de Paris, Université Paris-Sud, Le Kremlin Bicêtre, France., FrankrigFranck Carbonnel, Department of Gastroenterology, University Hospital of Bicêtre, Assistance Publique - Hôpitaux de Paris, Université Paris-Sud, Le Kremlin Bicêtre, France., FrankrigMarie-Christine Boutron-Ruault, Center for Research in Epidemiology and Population Health, French Institute of Health and Medical Research (Inserm), Institut Gustave Roussy, Villejuif, France., FrankrigAnne Tjønneland, Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark., DanmarkAnja Olsen, Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark., DanmarkVibeke Andersen, Institute of Regional Health Research-Center Soenderjylland, University of Southern Denmark , Odense DK-5230, Denmark., DanmarkRudolf Kaaks, Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany., TysklandTilman Kühn, Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany., TysklandRosario Tumino, Cancer Registry and Histopathology Unit "Civic - M.P. Arezzo "Hospital ASP Ragusa, Italy., ItalienAntonia Trichopoulou, Hellenic Health Foundation, Athens, Greece., GrækenlandPetra H M Peeters, Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, The School of Public Health, Imperial College, London, United Kingdom., StorbritannienW M Monique Verschuren, Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., HollandBen J M Witteman, Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands., HollandBas Oldenburg, Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands., Holland

Background: A low vitamin D status has been put forward as a potential risk factor for the development of inflammatory bowel disease (IBD). This study investigated the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative colitis (UC).

Methods: Among 359,728 participants of the European Prospective Investigation into Cancer and Nutrition cohort, individuals who developed CD or UC after enrollment were identified. Each case was matched with2 controls by center, gender, age, date of recruitment, and follow-up time. At cohort entry, blood samples were collected and dietary vitamin D intakes were obtained from validated food frequency questionnaires. Serum 25-hydroxyvitamin D levels were measured using liquid chromatography-tandem mass spectrometry. Conditional logistic regression was performed to determine the odds of CD and UC.

Results: Seventy-two participants developed CD and 169 participants developed UC after a median follow-up of 4.7 and 4.1 years, respectively. Compared with the lowest quartile, no associations with the 3 higher quartiles of vitamin D concentrations were observed for CD (p trend = 0.34) or UC (p trend = 0.66). Similarly, no associations were detected when serum vitamin D levels were analyzed as a continuous variable. Dietary vitamin D intakes were not associated with CD (p trend = 0.39) or UC (p trend = 0.83).

Conclusions: Vitamin D status was not associated with the development of CD or UC. This does not suggest a major role for vitamin D deficiency in the etiology of IBD, although larger studies are needed to confirm these findings.

OriginalsprogEngelsk
TidsskriftInflammatory Bowel Diseases
Vol/bind24
Tidsskriftsnummer3
Sider (fra-til)633-640
Antal sider8
ISSN1078-0998
DOI
StatusUdgivet - 15 feb. 2018

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