Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

DOI

    Santosh Lamichhane, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland. Electronic address: lamichhane17@gmail.com., Partho Sen, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland., Alex M Dickens, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland., Matej Orešič, Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro and Unit of Biostatistics, Institute of Evironmental Medicine, Karolinska Institutet, Stockholm, Sweden.,
  • Hanne Christine Bertram

It is well established that gut microbes and their metabolic products regulate host metabolism. The interactions between the host and its gut microbiota are highly dynamic and complex. In this review we present and discuss the metabolomic strategies to study the gut microbial ecosystem. We highlight the metabolic profiling approaches to study faecal samples aimed at deciphering the metabolic product derived from gut microbiota. We also discuss how metabolomics data can be integrated with metagenomics data derived from gut microbiota and how such approaches may lead to better understanding of the microbial functions. Finally, the emerging approaches of genome-scale metabolic modelling to study microbial co-metabolism and host-microbe interactions are highlighted.

OriginalsprogEngelsk
TidsskriftMethods
ISSN1046-2023
DOI
StatusE-pub ahead of print - 30 apr. 2018

    Forskningsområder

  • Gut microbiota, Microbiome, METABOLOMICS, genome-scale metabolic models, faecal metabolites

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