Transcutaneous cervical vagal nerve stimulation modulates cardiac vagal tone and tumor necrosis factor-alpha

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • C Brock
  • B Brock
  • Q Aziz, Centre for Neuroscience and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK.,
  • Holger Jon Møller
  • Mogens Pfeiffer Jensen
  • A M Drewes
  • Adam D Farmer, Mech-Sense, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark., Danmark
The vagus nerve is a central component of cholinergic anti-inflammatory pathways. We sought to evaluate the effect of bilateral transcutaneous cervical vagal nerve stimulation (t-VNS) on validated parameters of autonomic tone and cytokines in 20 healthy subjects. 24 hours after t-VNS, there was an increase in cardiac vagal tone and a reduction in tumor necrosis factor-α in comparison to baseline. No change was seen in blood pressure, cardiac sympathetic index or other cytokines. These preliminary data suggest that t-VNS exerts an autonomic and a subtle antitumor necrosis factor-α effect, which warrants further evaluation in larger controlled studies.
OriginalsprogEngelsk
Artikelnummere12999
TidsskriftNeuro-Oncology
Vol/bind29
Tidsskriftsnummer5
Antal sider4
ISSN1522-8517
DOI
StatusUdgivet - maj 2017

    Forskningsområder

  • Autonomic nervous system, Cholinergic anti-inflammatory pathway, Vagal nerve stimulation

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