Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review


    John Kurhanewicz, University of California, Daniel B Vigneron, University of California, Jan Henrik Ardenkjaer-Larsen, Center for Hyperpolarization in Magnetic Resonance, DTU, James A Bankson, Department of Imaging Physics, MD Anderson Medical Center, Houston, TX, USA., Kevin Brindle, Department of Biochemistry, University of Cambridge, StorbritannienCharles H Cunningham, University of Toronto, Sunnybrook Health Sciences Centre, CanadaFerdia A Gallagher, Department of Radiology, University of Cambridge and Addenbrooke’s Hospital, Cambridge, Kayvan R Keshari, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA, Andreas Kjaer, Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.,
  • Christoffer Laustsen
  • David A Mankoff, Department of Radiology, University of Pennsylvania, PA, USA, Matthew E Merritt, Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA., Sarah J Nelson, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, USA., John M Pauly, Department of Electric Engineering, Stanford University, USA., Philips Lee, Functional Metabolism Group, Singapore Biomedical Consortium, Agency for Science, Technology and Research, Singapore., Sabrina Ronen, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, USA., Damian J Tyler, Department of Biomedical Science, University of Oxford, Oxford, UK, StorbritannienSunder S Rajan, Center for Devices and Radiological Health (CDRH), FDA, White Oak, MD, USA., Daniel M Spielman, Departments of Radiology and Electric Engineering, Stanford University, USA., Lawrence Wald, 3 Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Xiaoliang Zhang, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, USA., Craig R Malloy, Advanced Imaging Research Center – Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA, Rahim Rizi, Department of Radiology, University of Pennsylvania, PA, USA

This white paper discusses prospects for advancing hyperpolarization technology to better understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13C magnetic resonance imaging's (MRI's) widespread clinical use, and provide recommendations for overcoming them. Since the publication of the first NIH white paper on hyperpolarized 13C MRI in 2011, preclinical studies involving [1-13C]pyruvate as well a number of other 13C labeled metabolic substrates have demonstrated this technology's capacity to provide unique metabolic information. A dose-ranging study of HP [1-13C]pyruvate in patients with prostate cancer established safety and feasibility of this technique. Additional studies are ongoing in prostate, brain, breast, liver, cervical, and ovarian cancer. Technology for generating and delivering hyperpolarized agents has evolved, and new MR data acquisition sequences and improved MRI hardware have been developed. It will be important to continue investigation and development of existing and new probes in animal models. Improved polarization technology, efficient radiofrequency coils, and reliable pulse sequences are all important objectives to enable exploration of the technology in healthy control subjects and patient populations. It will be critical to determine how HP 13C MRI might fill existing needs in current clinical research and practice, and complement existing metabolic imaging modalities. Financial sponsorship and integration of academia, industry, and government efforts will be important factors in translating the technology for clinical research in oncology. This white paper is intended to provide recommendations with this goal in mind.

Antal sider16
StatusUdgivet - 1 jan. 2019

Bibliografisk note

Copyright © 2018. Published by Elsevier Inc.

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