Dental Findings in Patients With Non-Surgical Hypoparathyroidism and Pseudohypoparathyroidism: A Systematic Review

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Background: Dental aberrations have been mentioned in relation to non-surgical
hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP). However, a
systematic review of dental characteristics have not been performed. The present
systematic review describes the dental findings in patients with Ns-HypoPT and PHP.
Methods: Studies on Ns-HypoPT and PHP reporting dental features were eligible.
A systematic literature search was conducted using four bibliographic databases (Web
of Science, Scopus, Pubmed, and Embase) and was limited to studies written in English.
Reviews, meta-analyses and letters were excluded. Both the research and reporting of
results were based on PRISMA (preferred Reporting Items for Systematic Reviews and
Meta-Analysis) guidelines.
Results: Of 88 studies included, nine were cross-sectional, one was a prospective
cohort study, 26 were case series, and 52 were case reports. The most frequently
reported findings in patients with Ns-HypoPT were enamel opacities, enamel hypoplasia,
hypodontia, and eruption disturbances. In patients with PHP, enamel hypoplasia,
eruption disturbance, and deviation of the root morphology were the most frequently
reported findings.
Conclusion: An association between enamel hypoplasia and Ns-HypoPT and PHP is
likely. The results should, however, be interpreted cautiously due to the limited number
of high-quality studies. The present review confirms the need of further well-designed
studies, such as large-scale studies, e.g., multicenter studies, to conclude on the
reported associations between Ns-HypoPT/PHP and enamel hypoplasia.
TidsskriftFrontiers in Physiology
Antal sider15
StatusUdgivet - 2018


  • hypoparathyroidism, pseudohypoparathyroidism, 22q11 deletion syndrome, dental anomalies, enamel

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