Steffen Thiel

Professor, Professor MSO

Curriculum Vitae for Steffen ThielFødt : 4. maj 1961 i Ålborg.Jan. 1987 :Cand. scient. i eksperimentel biologi med specia¬le i cellebio¬logi.Feb. 1987 - Maj 1987:Ophold ved MRC Immunochemistry Unit, Dept. of Biochemistry, OxfordUniversity, UK i prof. K.B.M. Reids laboratorie.Maj 1987 - Jan. 1990 :Kandidatstipendiat ved Institut for Medi¬cinsk Mikrobiologi, OdenseUniversitet.Juni 1988 - Juni 1989 :Ophold ved MRC Immunochemistry Unit, Dept. of Biochemistry, OxfordUniversity, UK i prof. K.B.M. Reids laboratorium.Jan. 1990 - Jan. 1994 :Adjunkt ved Institut for Medi¬cinsk Mikrobiologi, År¬hus Uni¬versitet.Dec. 1991 :Lic. scient.Jan. 1994 –Marts 2010 :Lektor ved Institut for Medi¬cinsk Mikrobiologi og Immun¬ologi, ÅrhusUniversitet.Juni 1996 - Juni 1997:Ophold ved UCSD Cancer Center, Glycobiology Programme, University of Califonia, San Diego, USA i prof. A. Varkis laboratorium.Marts 2010 :Professor MSO ved Institut for Medi¬cinsk Mikrobiologi og Immun¬ologi, Århus Universitet (nu Institut for Biomedicin, Aarhus Universitet). Publikationer i internationale engelsksprogede tidsskrifter:H-factor (januar 2015, web of science): 611.Jensenius, J.C., Thiel, S., Baatrup, G. and Holmskov-Niel¬sen, U. (1985), Human conglutinin-like protein, Bioscience Re¬ports, 5, 901-905.2.Thiel, S., Baatrup, G., Friis-Christiansen, P., Svehag, S-E and Jensenius, J.C. (1987), Characterization of a lectin in human plasma analogous to bovine conglutinin, Scand.J¬. Im¬munol., 26, 461-468.3.Baatrup, G., Thiel, S., Isager, H., Svehag, S-E. and Jense¬nius, J.C. (1987), Demonstration in human plasma of a lectin activity analogous to that of bovine congluti¬nin, Scand.J.Im¬munol., 26, 355-361.4.Thiel, S., and Reid, K.B.M. (1989), Structures and func¬tions associated with the group of mammalian lectins containing collagen-like sequences, FEBS Lett., 250, 78-84.5.Mizuochi, T., Loveless, R.W., Lawson, A.M., Chai, W., Lach¬mann, P.J., Childs, R.A., Thiel, S. and Feizi, T. (1989), A library of oligosaccharide probes (neoglycoli¬pids) from N-glycosylated proteins reveals that conglu¬tinin binds to cer¬tain complex-type as well as high mannose-type oligosac¬charide chains, J.Biol.¬Chem., 264, 13834-13839.6.Childs, R.A., Drickamer, K., Kawasaki, T., Thiel, S., Mizuo¬chi, T. and Feizi, T. (1989), Neoglycolipids as propes of oligosac¬charide recognition by recombinant and natural manno¬se-binding proteins of the rat and man, Biochem.J., 262, 131-138.7.Larkin, M., Childs, R.A., Matthews, T.J., Thiel, S., Mizuo¬chi, T., Lawson, A.M., Savil, J.S., Haslett, C., Diaz, R. and Feizi, T. (1989), Oligosaccharide-mediated interactions of the envelope glycoprotein gp 120 of HIV-1 that are independent of CD4 recognition, AIDS, 3, 793-798.8.Super, M., Thiel, S., Lu, J., Levinsky, R.J. and Turner, M.W. (1989), Association of low levels of mannan-binding protein with a common defect of opsonisation, Lancet,¬ Nov.25, 1236-1239.9.Friis-Christiansen, P., Thiel, S., Svehag, S-E, Dessau, R., Svendsen, P., Andersen, O., Laursen, S.B. and Jense¬nius, J.C. (1990), In vivo and in vitro antibacterial activity of conglu¬tinin, a mammalian plasma lectin, Scand.J.Immu¬nol., 31, 453-460.10.Lu, J., Thiel, S., Wiedemann, H., Timpl, R. and Reid,K.B.M. (1990), Binding of the pentamer/hexamer forms of mannan-bin¬ding protein to zymosan activates the porenzyme C1r2C1s2 complex, of the classical pathway of complement, without involvement of C1q, J.Immunol., 144, 2287-2294.11.Malhotra, R., Thiel, S., Sim, R.B., Reid, K.B.M. (1990), Human leukocyte C1q receptor binds other soluble pro¬teins with collagen domains, J.Exp.Med., 172, 955-959.12.Andersen, O., Laursen, S.B., Svehag, S-E., Holmskov, U., Thiel, S. (1991), Mammalian lectins in defence me¬cha¬nisms against microorganism, Lectin Rewievs, 1, 41.13.Malhotra, R., Haurum, J., Thiel, S., Sim, R.B. (1992), Inter¬action of C1q receptor with lung surfactant protein A, Eur. J. Immunol., 22, 1437-1445.14.Thiel, S., Holmskov, U., Hviid, L., Laursen, S.B., Jense¬nius, J.C. (1992), The concentration of the C-type lectin, mannan-binding protein, in human plasma increa¬ses during an acute phase response, Clin. Exp. Immunol., 90, 31-35.15.Thiel, S. (1992), Mannan-binding protein, a complement ¬activa¬ting animal lectin, Immunopharmacology, 24, 91-99.16.Garred, P., Thiel, S., Madsen, H.O., Ryder, L.P., Jense¬nius, J.C., Svejgård, A. (1992), Gene frequency and partial protein characterization of an allelic variant of mannan-binding protein associated with low serum concentrations, Clin. Exp¬. Immunol., 90, 517-521.17.Garred, P., Madsen, H.O., Kurtzhals, J.A.L., Lamm, L.U., Thiel, S., Hay, A.S., Svejgård, A. (1992), Diallelic poly¬morp¬hism may explain variations of the blood con¬centrations of mannan-binding protein in eskimos, but not in black africans, Immu¬nogenetics, 19, 403-412.18.Garred, P., Michaelsen, T.E., Bjune, G., Thiel, S., Svej¬gård, A. (1993), A low serum concentration of man¬nan-binding protein is not associated with serogroup B or C meningococcal disease, Scand.J.Immunol., 37, 468-470.19.Reid, K.B.M., Thiel, S. (1993), C1q and related molecu¬les in defence, in Kerr, M. and Sim, E. eds., The Na¬tural Immune system - Humoral factors. Oxford: IRL Press, Oxford Univer¬sity Press, chap. 6, 151-175.20.Lu, J., Laursen, S.B., Thiel, S., Jensenius, J., Reid, K.B.M. (1993), The cDNA cloning of conglutinin and identification of liver as a primary site of synthesis of conglutinin in members of the bovidae, Biochem. J., 292, 157-162.21.Haurum, J., Thiel, S., Haagsman, H.P., Laursen, S.B., Larsen, B., Jensenius, J.C. (1993), Studies on the carbohydrate characteristics of human pulmonary surfactant-associated protein A (SP-A). Com¬parison with two other collectins; Man¬nan-binding protein and conglutinin, Biochem. J., 293, 873-878.22.Lu, J., Wiedemann, H., Holmskov, U., Thiel, S., Timpl, R., Reid, K.B.M. (1993), Structural similarity between lung surfac¬tent protein D (SP-D) and cong¬lutinin: two dis¬tinct C-type lectins containing collagen-like sequences, Eur. J. Biochem., 215, 793-799. 23.Garred, P., Brygge, K., Sørensen, C.H., Madsen, H.O., Thiel, S., Svejgaard, A., Mannan-binding protein - Level in plasma and upper-airway secretions and frequency of genotypes in children with recurrence of otitis media, Clin. Exp. Immu¬nol., 94, 99-104.24.Malhotra, R., Haurum, J., Thiel, S., Jensenius, J.C.,, Sim, R.B. (1993), Pollen grains bind to lung alveolar type II cells (A549) via lung surfactant protein A (SP-A), Bioscience Report, 13, 79-90.25.Haurum, J., Thiel, S., Jones, I.M., Fischer, P., Laur¬sen, S.B., Jensenius, J.C. (1993), Complement activation upon binding of mannan-binding protein to HIV envelope glycoproteins, AIDS, 7, 1307-1313.26.Laursen, S.B., Thiel, S., Teisner, B., Holmskov, U., Jense¬nius, J.C. (1994), The bovine serum lectin conglutinin binds liquid phase iC3b, but not C3b or C3c, Immunol., 81, 648-654.27.Holt, P., Holmskov, U., Thiel, S., Teisner, B., Højrup, P., Jensenius, J.C. (1994), Purification and characterization of mannan-binding protein from mouse serum., Scand. J. Immunol., 39, 202-208.28.Malhotra, R., Lopez Bernal, A., Thiel, S., Sim, R.B. (1994), Mannan-binding protein levels in human amniotic fluid during gestation and its interaction with collectin receptor from amnion cells, Immunol., 82, 439-444.29.Madsen, H.O., Garred, P., Kurtzhals, J.A.L., Lamm, L.U., Ryder, L.P., Thiel, S., Svejgaard, A. (1994), A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein, Immunogenetics, 40, 37-44.30.Fischer, P.B., Ellerman-Eriksen, S., Thiel, S., Jensenius, J.C., Mogensen, S.C. (1994), Mannan-binding protein and bovine conglutinin mediate enhancement of herpes simplex virus type 2 infection in mice. Scand. J. Immunol., 39, 439-445.31.Green, P.J., Stoll, M.S., Feizi, T., Thiel, S., Prescott, A., McConville, M.J. (1994), Recognition of the major cell surface glycoconjugates of Leishmania parasites by the human mannan-binding protein, Mol. Biochem. Parasitol., 66, 319-328.32.Van Emmerik, L., Kuijper, E., Dankert, J., Thiel, S. (1994), Binding of mannan-binding protein to bacterial pathogens of meningitis, Clin. Exp. Immunol., 97, 411-416.33.Malhotra, R., Haurum, J.S., Thiel, S., Sim, R.B. (1994), Binding of human collectins (SP-A and MBP) to influenza virus, Biochem. J., 304, 455-461.34.Thiel, S., Bjerke, T., Hansen, D., Poulsen, L.K., Schi¬øtz, P.O., Jensenius, J.C. (1995), Ontoge¬ny of human mannan-binding protein, a lectin of the innate immune system, Ped. Aller. Immunol., 6, 20-23.35.Homann, C., Garred, P., Hasselqvist, P., Graudal, N., Thiel, S., Thomsen, Å.C. (1995), Mannan-binding protein and complement dependent opsonization in alcoholic cirrhosis, Liver, 15, 39-44.36.Laursen, S., Hedemand, J.E., Thiel, S., Willis, A.C., Madsen, P.S., Jensenius, J.C. (1995), Collectin in a non-mammalian species: Isolation and characterisation of mannan-binding protein (MBP) from chicken serum, Glycobiol., 5, 553-561.37.Hynsjö, L., Granberg, L., Haurum, J., Thiel, S., Larson, G. (1995), Use of factorial experimental design to delineate the strong calcium and ph dependent changes in binding of human surfactant protein-A to neutral glycoshingolipids: A model for studies of protein-carbohydrate interactions, Anal. Biochem., 225, 305-314.38.Jensen, L.E., Petersen, T.E., Thiel, S., Jensenius, JC (1995), Isolation of a pentraxin-like protein from rainbow trout serum, Dev. Comp. Immunol., 19, 305-314.39.Lyhne, S.N., Andersen, P.L., Koch, C., Jensenius, J.C., Thiel, S. (1995), The level of the serum opsonin, mannan-binding protein in HIV-1 antibody positive patients, Clin. Exp. Immunol., 100, 219-222.40.Madsen, H.O., Garred, P., Thiel, S., Kurtzhals, J.A., Lamm, L., Ryder, L.P., Svejgaard, A. (1995), Interplay between promoter- and structural gene variants control the basal serum concentration of mannan-binding protein J.Immunol., 155, 3013-3020.41.Mårtensson, U., Thiel, S., Jensenius, J.C., Sjöholm, A.G. (1996), Human autoantibodies against C1q: lack of cross-reactivity with the collectins mannan-binding protein, lung surfactant protein A and bovine congluti¬nin, Scand. J. Immunol., 43, 314-320.42.Tan, S.M., Chung, M.C.M., Kon, O.L., Thiel, S., Lee, S.H., Lu, J. (1996), Improvements on the purification of mannan-binding lectin and demonstration of its calcium dependent association with a C1s-like serine protease, Biochem. J., 319, 329-332.43.Franzyk, H., Meldahl, M., Paulsen, H., Thiel, S., Jensenius, J.C., Bock, K. (1996), Glycopeptide mimics of mammalian Man9GlcNAc2. Ligand binding to mannan-binding proteins (MBPs), Bioorg. Medicinal Chem., 4, 1881-1899.44.Jensen, L.E., Thiel, S., Petersen, T.E., Jensenius, J.C. (1997), A rainbow trout lectin with multimeric structure, Comp. Biochem. Physiol., 116, 385-390.45.Thiel, S., Vorup-Jensen, T., Stover, C.M., Schwable, W., Laursen, S.B., Poulsen, K., Willis, A.C., Eggleton, P., Hansen, S., Holmskov, U., Reid, K.B.M., Jensenius, J.C. (1997), A second serine protease associated with mannan-binding lectin that activates complement, Nature, 386, 506-510.46.Prohaska, Z., Thiel, S., Ujhelyi, E., Szlavik, J., Banhegyi, D., Fust, G. (1997), Mannan-binding lectin serum concentrations in HIV-infected patients are influenced by the stage of disease, Immunol. Lett., 58, 171-175.47.Drogari-Apiranthiou, M., Fijn, C.A.P., Thiel, S., Platonov, A., Jensen, L., Dankert, J., Kuijper, E.J. (1997). The effect of mannan-binding lectin on opsonopha¬gocyto¬sis of Neisseria meningitidis, Immunopharm., 38, 93-99.48.Laursen, S.B., Dalgaard, T.S., Thiel, S., Lim, B.L., Jensen, T.V., Juul-Madsen, H.R., Takahashi, A., Hamana, T., Kawakami, M., Jensenius, J.C. (1998). Cloning and sequencing of a cDNA encoding chicken mannan-binding lectin (MBL) and comparision with mammalian analogues, Immunology, 93, 421-430.49.Lanzrein, A-S, Jobst, K.A., Thiel, S., Jensenius, J.C., Perry, V.H., Ezekowitz, R.A.B., Sim, R.B., Sim, E. (1998). Mannan-binding protein in human serum, cerospinal fluid and brain tissue and its role in Alzheimer's disease, NeuroReport, 9, 1491-1495.50.Laursen, S.B., Hedemand, J.E., Nielsen, O.L., Thiel, S., Koch, C., Jensenius, J.C. (1998). Serum levels, ontogeny and heritability of chicken mannan-binding lectin. Immunology, 94, 431-436.51.Valdimarsson, H., Stefansson, S., Vikingsdottir, T., Arason, G.J., Koch, C., Thiel, S., Jensenius, J.C. (1998). Reconstitution of opsonizing activity by infusion of mannan-binding lectin (MBL) to MBL deficient humans, Scand. J. Immunol., 48, 116-123. 52.Vorup-Jensen, T., Jensenius, J.C., Thiel, S. (1998). MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway, Immunobiol., 199, 348-347.53.Christiansen, O.B., Kilpatrick, D.C., Souter, V., Varming, K., Thiel, S., Jensenius, J.C. Mannan-binding lectin deficiency is associated with unexplained recurrent miscarriage (1999). Scand. J. Immunol., 49, 193-196.54.Stover, C.M., Schwaeble, W.J., Lynch, N.J., Thiel, S., Jensenius, J.C., Speicher, M.R. (1999). Assignment of the gene encoding Mannose binding lectin associa¬ted serine protease (MASP-2) to human chromosome 1q36.2-3 by in situ hybridization an somatic cell hybrid analysis , Cytogenetics and Cell Genetics, 84, 148-149.55.Stower, C.M., Thiel, S., Thelen, M., Lynch, N.J., Vorup-Jensen, T., Jensenius, J.C., Schwaeble, W.J. (1999). Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene, J. Immunol., 162, 3481-3490.56.Kuijper, E.J., Fijen, C.A., Dankert, J., Thiel, S. (1999). Mannose-binding lectin and meningococcal disease. Lancet, 354 (9175), 338.57.Stover, C.M., Thiel, S., Lynch, N.J., Schwable, W.J. (1999) The rat and mouse homologues of MASP-2 and MAp19, components of the lectin activation pathway of complement, J. Immunol., 163, 6848-6859. 58.Hansen, S., Thiel, S., Willis, A., Holmskov, U., Jensenius, J.C. (2000) Purification and characterization of two mannan-binding lectins from mouse serum, J. Immunol., 164, 2610-2618.59.Bajtay Z, Jozsi M, Banki Z, Thiel S, Theilens N, Erdei A (2000), Mannan-binding lectin and C1q bind to distinct structures and exert differential effects on macrophages., European J. Immunol., Eur J Immunol , 30(6):1706-13.60.Steffensen, R., Thiel, S., Varming, K., Jersild, C., Jensenius, J.C. (2000), Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers., J Immunol Methods 31;241(1-2):33-42.61.Thiel, S., Petersen, S.V., Vorup-Jensen, T., Matsushita, M., Fujita, T., Stover, C.M., Schwaeble, W.J., Jensenius, J.C. (2000), Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19., J. Immunol., 165(2):878-87.62.Vorup-Jensen T, Petersen SV, Hansen AG, Poulsen K, Schwaeble W, Sim RB, Reid KB, Davis SJ, Thiel S, Jensenius JC (2000), Distinct Pathways of Mannan-Binding Lectin (MBL)- and C1-Complex Autoactivation Revealed by Reconstitution of MBL with Recombinant MBL-Associated Serine Protease-2. J. Immunol., 165(4):2093-2100.63.Matsushita, M., Thiel, S., Jensenius, J.C., Terai, I., Fujita, T. (2000), Proteolytic activities of two types of mannose-binding lectin-associated serine proteases, J. Immunol., 165(5):2637-42.64.Gadjeva, M., Thiel, S., Jensenius, J.C. (2001), The mannan-binding-lectin pathway of the innate immune response. Curr Opin Immunol., 13(1):74-78.65.Vorup-Jensen T, Sørensen, E., Jensen, U.B., Schwaeble W, Kawasaki, T., Ma, Y., Uemura, K., Wakamiya, N., Suzuki, Y., Jensen, T.G., Takahashi, K., Ezekowitz, R.A.B., Thiel, S., Jensenius J.C. (2001) Recombinant expression of human mannan-binding lectin. International Immunopharmacology, 1: 677.687.66.Petersen SV, Thiel S, Jensen L, Vorup-Jensen T, Koch C, Jensenius JC. (2001) Control of the classical and the MBL pathway of complement activation. Mol Immunol. 37(14):803-11.67.Liu H, Jensen L, Hansen S, Petersen SV, Takahashi K, Ezekowitz AB, Hansen FD, Jensenius JC, Thiel S. (2001) Characterization and quantification of mouse mannan-binding lectins (MBL-A and MBL-C) and study of acute phase responses. Scand J Immunol., 53 :489-97.68.Stover C, Endo Y, Takahashi M, Lynch NJ, Constantinescu C, Vorup-Jensen T, Thiel S, Friedl H, Hankeln T, Hall R, Gregory S, Fujita T, Schwaeble W. (2001) The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. Genes Immun., 2 :119-27.69.Thielens, N.M., Cseh, S., Thiel, S., Vorup-Jensen, T., Rossi, V., Jensenius, J.C., Arlaud, G. (2001) Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and –2, MBL-associated protein 19, and MBL. J. Immunol., 166:5068-77.70.Thomas Vorup-Jensen, Uffe B. Jensen, Hong Liu, Toshisuke Kawasaki, Kazuhide Uemura, Steffen Thiel, Frederik Dagnæs-Hansen, Thomas G. Jensen (2001). Tail vein injection of mannan-binding lectin DNA leads to high levels of liver expression of multimeric protein. Mol Ther. 3(6):867-74. 71.Niels Anker Peterslund, Claus Koch, Jens C Jensenius and Steffen Thiel (2001). Association between deficiency of mannose-binding lectin and severe infections after chemotherapy. Lancet, 358, 637-638.72.Mads R. Dahl, Steffen Thiel, Misao Matsushita, Teizo Fujita, Anthony C. Willis, Tove Christensen, Thomas Vorup-Jensen and Jens C. Jensenius (2001). Masp-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity. 15(1):127-3.73. Hansen TK, Thiel S, Dall R, Rosenfalck AM, Trainer P, Flyvbjerg A, Jorgensen JO, Christiansen JS. GH Strongly Affects Serum Concentrations of Mannan-Binding Lectin: Evidence for a New IGF-I Independent Immunomodulatory Effect of GH. J Clin Endocrinol Metab. 2001, 86(11):5383-8.74.Petersen SV, Thiel S, Jensen L, Steffensen R, Jensenius JC. An assay for the mannan-binding lectin pathway of complement activation. J Immunol Methods. 2001, 257(1-2):107-16.75.Steen V. Petersen, Steffen Thiel, Jens C. Jensenius (2001). The mannan-binding lectin pathway of complement activation: biology and disease association, Mol. Immunol., 38, 133-149.76.Celik I, Stover C, Botto M, Thiel S, Tzima S, Kunkel D, Walport M, Lorenz W, Schwaeble W. Role of the classical pathway of complement activation in experimentally induced polymicrobial peritonitis. Infect Immun. 2001, 69, 7304-9.77. Takahashi, K., Gordon, J., Liu, H., Sastry, K.N., Epstein, JE, Motwani, M., Laursen, I., Thiel, S., Jensenius, JC, Carroll, M., Ezekowitz, RAB. 2002. Lack of mannose-binding protein-A enhances survival in a mouse model of acute septic peritonits. Microbes and Infection, 4, 773-784.78.Thiel, S., Møller-Kristensen, M., Jensen, L., Jensenius, J.C., 2002, Assays for the functional activity of the mannan-binding lectin pathway of complement activation, Immunobiology, 205, 446-454.79.Uemura, K., Saka, M., Nakagawa, T., Kawasaki, N., Thiel, S., Jensenius, J.C., Kawasaki, T. 2002. L-MBL is expressed in epithelial cells of mouse small intestine. J Immunol. 169:6945-50.80.Schwable W, Dahl MR, Thiel S, Stiver C, Jensenius JC. 2002. The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes. Immunobiology. 205:455-66.81.Kuraya M, Matsushita M, Endo Y, Thiel S, Fujita T. 2003. Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G. Int Immunol., 15:109-17.82.Sif Kielgast, Steffen Thiel, Tine B. Henriksen, Torbjørn Bjerke, Jørn Olsen, Jens C. Jensenius. 2003. Umbilical cord mannan-binding lectin and infections in early childhood, Scand. J. Immunol., 57:167-72.83.Hansen, T.K., Thiel, S., Wouters, P., Christiansen, J.S., van den Berghe, G. 2003. Intensive insulin therapy exerts anti-inflammatory effects in critically ill patients, and counteracts the adverse effect of low mannose-binding lectin levels, J Clin Endocrinol Metab., 88:1082-8.84.Stover, C.M., Lynch, N.J., Dahl, M.R., Hanson, S., Takahashi, M., Frankenberger, M., Ziegler-Heitbrock, L., Eperon, I., Thiel, S., Schwaeble, W.J. 2003. Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single structural gene, Genes Immun., 4:374-84.85.Holmskov U, Thiel S, Jensenius JC. 2003. Collectins and ficolins: humoral lectins of the innate immune defense, Ann Rev Immunol., 21:547-78.86.Møller-Kristensen M, Thiel S, Hansen A, Jensenius JC. 2003. On the site of C4 deposition upon complement activation via the MBL pathway or the classical pathway, Scand J Immunol., 57:556-561.87.Varga L, Szilagyi K, Lorincz Z, Berrens L, Thiel S, Zavodszky P, Daha MR, Thielens NM, Arlaud GJ, Nagy K, Spath P, Fust G. 2003. Studies on the mechanisms of allergen-induced activation of the classical and lectin pathways of complement. Mol Immunol, 39:839-46.88.Kristian Stengaard-Pedersen, Steffen Thiel, Mihaela Gadjeva, Mette Møller-Kristensen, Rikke Sørensen, Lise T. Jensen, Anders G. Sjöholm, Lars Fugger, Jens C. Jensenius. 2003. Inherited deficiency of mannan-binding lectin-associated serine protease-2, New Eng J Medicine, 349:554-560.89. Troels Krarup Hansen, Steffen Thiel, Søren Tang Knudsen, Claus Højbjerg Gravholt, Jens Sandahl Christiansen, Carl Erik Skibsted Mogensen, Per Løgstrup Poulsen, 2003, Elevated levels of mannan-binding lectin in patients with type 1 diabetes. J Clin Endocrinol Metab., 88:4857-61.90.Mette Møller-Kristensen, Jens Chr. Jensenius, Lisbeth Jensen, Nicole Thielens, Véronique Rossi, Gerard Arlaud, Steffen Thiel, 2003. Levels of mannan-binding lectin-associated serine protease-2 (MASP-2) in healthy individuals J Immunol Methods, 282:159-67.91.Jensenius JC, Jensen PH, McGuire K, Larsen JL, Thiel S Recombinant mannan-binding lectin (MBL) for therapy. Biochem Soc Trans. 2003. 31(Pt 4):763-792.Troels Krarup Hansen, Lise Tarnow, Steffen Thiel, Rudi Steffensen, Hans-HenrikParving and Allan Flyvbjerg. Association between mannose-binding lectin and vascular complications in type 1 diabetes. Diabetis, Diabetes. 2004. 53:1570-6. 93.Gravholdt, C.H., Leth-Larsen, R., Lauridsen, A.L., Thiel, S., Hansen, T.K., Holmskov, U., Naeraa, R.W., Christiansen, J.S. The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndrome. Eur J Endocrinol. 2004. 150:355-62.94.Kristensen IA, Thiel S, Steffensen R, Madhi S, Sorour G, Olsen J. Mannan-binding lectin and RSV lower respiratory tract infection leading to hospitalization in children: a case-control study from Soweto, South Africa. Scand J Immunol. 2004. 60:184-895.Gadjeva M, Takahashi K, Thiel S. Mannan-binding lectin--a soluble pattern recognition molecule. Mol Immunol. 2004, 41(2-3):113-2196.M. Gadjeva, S. R. Paludan, S. Thiel, V. Slavov, M. Ruseva, K. Eriksson, Gun-Britt Löwhagen, K. Takahashi, A. Ezekowitz, J.C. Jensenius. Mannan-binding lectin modulates the response to HSV-2 infection, 2004, Clin Exp Immunol, 138:304-11.97.Henriette Ytting, Jens Christian Jensenius, Ib Jarle Christensen, Steffen Thiel, Hans Jørgen Nielsen. (2004) Increased activity of the mannan-binding lectin (MBL) complement activation pathway in patients with colorectal cancer. Scand J Gastroenterol. 39:674-9.98.Anders Krarup, Steffen Thiel, Annette Hansen, Teizo Fujita, Jens C. Jensenius. (2004) L-ficolin is a pattern recognition molecule specific for acetyl groups. J Biol Chem. 279:47513-9.98.Shi L, Takahashi K, Dundee J, Shahroor-Karni S, Thiel S, Jensenius JC, Gad F, Hamblin MR, Sastry KN, Ezekowitz RA. (2004) Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J Exp Med., 199:1379-90.99.Henriette Ytting, Ib Jarle Christensen, Jens Christian Jensenius, Steffen Thiel, Hans Jørgen Nielsen. (2005) Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer. Cancer Immunology Immunotherapy, 54:265-72.100.Markku Saraheimo, Allan Flyvbjerg, Anna-Maija Teppo, Carol Forsblom, Johan Fagerudd, Kim Pettersson-Fernholm, Troels Krarup Hansen, Steffen Thiel, Pertti Ebeling, Per-Henrik Groop on behalf of the FinnDiane Study Group. (2005). Increased levels of mannan-binding lectin in type 1 diabetic patients with incipient and overt nephropathy. Diabetologia 48:198-202.101.Anders Krarup, Uffe B. Skov Sørensen, Misao Matsushita, Jens C. Jensenius, Steffen Thiel. (2005) Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin and H-ficolin. Infection and immunity. Infect Immun. 73:1052-60.102.Malin Carlsson, Anders G. Sjöholm, Leif Eriksson, Steffen Thiel, Jens C. Jensenius, Mårten Segelmark, Lennart Truedsson Deficiency of the MBL pathway of complement and poor outcome in cystic fibrosis: bacterial colonization may be decisive for a relationship. Clin Exp Immunol. 2005. 139(2):306-13.103.Henriette Ytting, Ib Jarle Christensen, Steffen Thiel, Jens Christian Jensenius, Hans Jørgen Nielsen. (2005) Serum mannan-binding lectin-associated serine protease 2 levels in colorectal cancer: relation to recurrence and mortality.Clin Cancer Res. 11:1441-6.104.Mette Møller-Kristensen, Weidong Wang, Marieta Ruseva, Steffen Thiel, Søren Nielsen, Kazue Takahashi, Lei Shi, Alan Ezekowitz, Jens Chr. Jensenius, Mihaela Gadjeva. (2005) Mannan-binding lectin recognizes structures on ischemic reperfused mouse kidneys and is implicated in tissue injury. Scand. J. Immunol., 61:426-434.105.Madan T, Kaur S, Saxena S, Singh M, Kishore U, Thiel S, Reid KB, Sarma PU. Role of collectins in innate immunity against aspergillosis. Med Mycol. 2005. 43 Suppl 1:S155-63.106.Savneet Kaur, Vijay Kumar Gupta, Ashok Shah, Steffen Thiel, Puranam Usha Sarma, Taruna Madan. Plasma mannan-binding lectin levels and activity are increased in allergic patients. J Allergy Clin Immunol. 2005 116(6):1381-3.107.Hovind P, Hansen TK, Tarnow L, Thiel S, Steffensen R, Flyvbjerg A, Parving HH. Mannose-binding lectin as a predictor of microalbuminuria in type 1 diabetes: an inception cohort study. Diabetes. 2005, 54(5):1523-7.108.Anne Lene Dalkjær Riis, Troels Krarup Hansen, Steffen Thiel, Claus Højbjerg Gravholt, Signe Gjedde, Lars Christian Gormsen, Jens Otto Lunde Jørgensen, Jørgen Weeke and Niels Møller Thyroid hormone increases mannan-binding lectin levels. European Journal of Endocrinology 2005, 153(5):643-9109.Siassi M, Riese J, Steffensen R, Meisner M, Thiel S, Hohenberger W, Schmidt J. Mannan-binding lectin and procalcitonin measurement for prediction of postoperative infection. Crit Care. 2005, 9(5):R483-9.110.Ostergaard J, Hansen TK, Thiel S, Flyvbjerg A Complement activation and diabetic vascular complications. Clin Chim Acta. 2005, 361(1-2):10-9.111.Frederiksen PD, Thiel S, Larsen CB, Jensenius JC M-ficolin, an innate immune defence molecule, binds patterns of acetyl groups and activates complement. Scand J Immunol. 2005 62(5):462-73.112.Sorensen R, Thiel S, Jensenius JC Mannan-binding-lectin-associated serine proteases, characteristics and disease associations. Springer Semin Immunopathol. 2005 27(3):299-319.113.Thiel S, Frederiksen PD, Jensenius JC. Clinical manifestations of mannan-binding lectin deficiency. Mol Immunol. 2006 43(1-2):86-96.114.Kaur S, Gupta VK, Shah A, Thiel S, Sarma PU, Madan T. Elevated levels of mannan-binding lectin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL. Clin Exp Immunol. 2006, 143(3):414-419.115.Moller-Kristensen M, Ip WK, Shi L, Gowda LD, Hamblin MR, Thiel S, Jensenius JC, Ezekowitz RA, Takahashi K. Deficiency of Mannose-Binding Lectin Greatly Increases Susceptibility to Postburn Infection with Pseudomonas aeruginosa. J Immunol. 2006, 176(3):1769-75.116.C. M. Sørensen , T. K. Hansen , R. Steffensen , J. C. Jensenius, S. Thiel. Hormonal regulation of mannan-binding lectin synthesis in hepatocytes. Clinical and Experimental Immunology 2006; 145 (1),173-182.117.Molle I, Steffensen R, Thiel S, Peterslund NA. Chemotherapy-related infections in patients with multiple myeloma: associations with mannan-binding lectin genotypes. Eur J Haematol. 2006. 77(1):19-26.118.Ytting H, Christensen IJ, Basse L, Lykke J, Thiel S, Jensenius JC, Nielsen HJ. Influence of major surgery on the mannan-binding lectin pathway of innate immunity. Clin Exp Immunol. 2006;144(2):239-46.119.Selander B, Martensson U, Weintraub A, Holmstrom E, Matsushita M, Thiel S, Jensenius JC, Truedsson L, Sjoholm AG. Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2. J Clin Invest. 2006 116(5):1425-34120.Hjelmesaeth J, Ueland T, Flyvbjerg A, Bollerslev J, Leivestad T, Jenssen T, Hansen TK, Thiel S, Sagedal S, Roislien J, Hartmann A. Early Posttransplant Serum Osteoprotegerin Levels Predict Long-Term (8-Year) Patient Survival and Cardiovascular Death in Renal Transplant Patients. J Am Soc Nephrol. 2006;17(6):1746-1754.121.Kaur S, Thiel S, Sarma PU, Madan T. Mannan-Binding Lectin in Asthma and Allergy.Curr Allergy Asthma Rep. 2006;6(5):377-83.122. Kenneth A Petersen, Finn Matthiesen, Teit Agger, Leif Kongerslev, Steffen Thiel,Karen Cornelissen, and Mads Axelsen. Phase I Safety, Tolerability, and Pharmacokinetic Study of Recombinant Human Mannan-Binding Lectin. Journal of Clinical Immunology, 2006, 26(5), 465-475.123.Molle I, Peterslund NA, Thiel S, Steffensen R. MBL2 polymorphism and risk of severe infections in multiple myeloma patients receiving high-dose melphalan and autologous stem cell transplantation. Bone Marrow Transplant. 2006, 38(8):555-60.124.Zhang M, Takahashi K, Alicot EM, Vorup-Jensen T, Kessler B, Thiel S, Jensenius JC, Ezekowitz RA, Moore FD, Carroll MC. Activation of the Lectin Pathway by Natural IgM in a Model of Ischemia/Reperfusion Injury. J Immunol. 2006, 177(7):4727-34.125.Troels Krarup Hansen, Mari-Anne Gall, Lise Tarnow, Steffen Thiel, Coen D. Stehouwer, Casper G. Schalkwijk, Hans-Henrik Parving, Allan Flyvbjerg. Mannose-Binding Lectin and Mortality in Type 2 Diabetes. Arch Intern Med. 2006;166:2007-2013.126.Olesen HV, Jensenius JC, Steffensen R, Thiel S, Schiotz PO. The mannan-binding lectin pathway and lung disease in cystic fibrosis--disfunction of mannan-binding lectin-associated serine protease 2 (MASP-2) may be a major modifier. Clin Immunol. 2006, 121(3):324-31.127.Rasmus Gaardskaer Nielsen, Ida Vind, Pia Munkholm, Jens Christian Jensenius,Steffen Thiel, Steffen Husby. Genetic polymorphisms of Mannan-binding lectin (MBL), serum levels of MBL, the MBL-associated serine protease and H-ficolin in patients with Crohn’s disease. Gut, 2007, 56, 311-312128.Tove Christensen, Thor Petersen, Steffen Thiel, Tomasz Brudek, Svend Ellermann-Eriksen, Anné Møller-Larsen. Gene–environment interactions in multiple sclerosis: Innate and adaptive immune responses to human endogenous retrovirus and herpes virus antigens and the lectin complement activation pathway. Journal of Neuroimmunology, 2007;183(1-2):175-88.129.Grith L. Sorensen, Inge Petersen, Steffen Thiel, Mogens Fenger, Kaare Christensen, Kirsten O. Kyvik, Thorkild I. A. Sørensen, Uffe Holmskov and Jens Christian Jensenius. Genetic Influences on Mannan-Binding Lectin (MBL) and Mannan-Binding Lectin Associated Serine Protease-2 (MASP-2) Activity. Genetic Epidemiology, 2007; 31(1):31-41.130.Mette Møller-Kristensen, Michael R. Hamblin, Steffen Thiel, Jens Chr. Jensenius, Kazue Takahashi. Burn injury reveals altered phenotype in mannan-binding lectin deficient mice. J. Invest. Dermatol. 2007. 127(6):1524-31.131.Ming Dong, Sailong Xu, Cristiano L. P. Oliveira, Jan S. Pedersen, SteffenThiel, Flemming Besenbacher, Thomas Vorup-Jensen. Conformational changes in mannan-binding lectin bound to ligand surfaces, J Immunol, 2007, 178(5):3016-22.132.S Thiel, R Steffensen, IJ Christensen, WK Ip, YL Lau, IJM Reason, H Eiberg, M Gadjeva, M Ruseva, and JC Jensenius. Deficiency of mannan-binding lectin associated serine protease-2 (MASP-2) due to missense polymorphisms, Genes and Immunity, 2007, 8(2):154-63.133.SE Degn, S Thiel, JC Jensenius. New perspectives on mannan-binding lectin-mediated complement activation. Immunobiology. 2007;212(4-5):301-11.134.Florence Teillet, Monique Lacroix, Steffen Thiel, Dietmar Weilguny, Teit Agger, Gérard J. Arlaud, Nicole M. Thielens. Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55, J. Immunol., 2007, 178(9):5710-6.135.S. Kaur, V. K. Gupta, S. Thiel, P. U. Sarma, T. Madan. Protective role of mannan-binding lectin in a murine model of invasive pulmonary aspergillosis. Clin. Exp. Immunol., 2007, 148(2):382-9.136.Glerup S, Kloverpris S, Laursen LS, Dagnaes-Hansen F, Thiel S, Conover CA, Oxvig C. Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor. J Biol Chem. 2007 282(3):1769-78.137.Moller-Kristensen M, Thiel S, Sjoholm A, Matsushita M, Jensenius JC Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway. Int. Immunol. 2007, 19(2):141-9.138.Eszter Csomor, Zsuzsa Bajtay, Noémi Sándor, Katalin Kristóf, Gérard J. Arlaud, Steffen Thiel and Anna Erdei. Complement protein C1q induces maturation of human dendritic cells. Mol Immunol. 2007, 44(13):3389-97.139.Ostergaard J, Thiel S, Gadjeva M, Hansen TK, Rasch R, Flyvbjerg A. Mannose-binding lectin deficiency attenuates renal changes in a streptozotocin-induced model of type 1 diabetes in mice. Diabetologia. 2007. 50(7):1541-9.140.Patricia M. L. Ng, Chia M. Lee, Agnes Le Saux, Nguan S. Tan, Jinhua Lu, SteffenThiel, Bow Ho, Jeak L. Ding, C-reactive protein collaborates with plasma lectins toboost immune response against bacteria. EMBO J. 2007. 26(14):3431-40.141.Thiel S. Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Molecular Immunology, 2007, 44(16):3875-88.142.Ytting H, Christensen IJ, Thiel S, Jensenius JC, Svendsen MN, Nielsen L, Lottenburger T, Nielsen HJ. Biological Variation in Circulating Levels of Mannan-Binding Lectin (MBL) and MBL-Associated Serine Protease-2 and the Influence of Age, Gender and Physical Exercise. Scand J Immunol. 2007, 66(4):458-64.143.Hansen S, Schmidt V, Steffensen MA, Jensen PH, Gjerstorff M, Thiel S, Holmskov U. An enzyme-linked immunosorbent assay (ELISA) for quantification of mouse surfactant protein D (SP-D). J Immunol Methods. 2008, 330(1-2):75-85.144.Franz Petry, Vera Jakobi, Swen Wagner, Tesfaye Sisay Tessema, Steffen Thiel and Michael Loos. Binding and activation of human and mouse complement by Cryptosporidium parvum (Apicomplexa) and susceptibility of C1q- and MBL-deficient mice to infection. Molecular Immunology, 2008. 45(12):3392-400.145.Ytting H, Christensen IJ, Thiel S, Jensenius JC, Nielsen HJ. Pre- and postoperative levels in serum of mannan-binding lectin associated serine protease-2 -a prognostic marker in colorectal cancer. Hum Immunol. 2008. 69(7):414-20.146.Held K, Thiel S, Loos M, Petry F. Increased susceptibility of complement factor B/C2 double knockout mice and mannan-binding lectin knockout mice to systemic infection with Candida albicans. Mol Immunol. 2008, 45(15):3934-41.147.Sagedal S, Thiel S, Hansen TK, Mollnes TE, Rollag H, Hartmann A. Impact of the complement lectin pathway on cytomegalovirus disease early after kidney transplantation. Nephrol Dial Transplant. 2008, 23(12):4054-60.148.L. Henckaerts, K. R. Nielsen, R. Steffensen, K. Van Steen, C. Mathieu, A.Giulietti, P. J. Wouters, I. Milants, I. Vanhorebeek, L. Langouche, S, Vermeire, P.Rutgeerts, S. Thiel, A. Wilmer, T. K. Hansen, G. Van den Berghe. Polymorphisms in innate immunity genes predispose to bacteraemia and death in the medical intensive care unit, Crit Care Med. 2009, 37(1):192-201.149.Jing Zhang, Jingyun Koh, Jinhua Lu, Steffen Thiel, Benjamin S. H. Leong, Sunil Sethi, Cynthia Y. X. He, Bow Ho, Jeak L. Ding. Local Inflammation Induces Complement Crosstalk Which Amplifies the Antimicrobial Response. PLoS Pathog, 2009. 5(1): e1000282.150.Thiel S, Kolev M, Degn S, Steffensen R, Hansen AG, Ruseva M, Jensenius JC. Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. J Immunol. 2009, 182:2939-47.151.Thor Petersen, Anné Møller-Larsen, Steffen Thiel, Tomasz Brudek, Troels Krarup Hansen, Tove Christensen. Effects of interferon-beta therapy on innate and adaptive immune responses to human endogenous retrovirus, cytokine production, and the lectin complement activation pathway in multiple sclerosis. J Neuroimmunol, 2009 Oct 30;215(1-2):108-16.152.Ruseva M, Kolev M, Dagnaes-Hansen F, Hansen SB, Takahashi K, Ezekowitz A, Thiel S, Jensenius JC, Gadjeva M. Mannan-binding lectin deficiency modulates the humoral immune response dependent on the genetic environment. Immunology. 2009;127(2):279-88.153.Chen Y, Khanna S, Goodyear CS, Park YB, Raz E, Thiel S, Grönwall C, Vas J, Boyle DL, Corr M, Kono DH, Silverman GJ. Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis. J Immunol. 2009;183:1346-59. 154. Thomas Wittenborn, Steffen Thiel, Lisbeth Jensen, Hans J. Nielsen, Jens C. Jensenius. Characteristics and Biological Variations of M-Ficolin, a Pattern Recognition Molecule, in Plasma. J Innate Immun. 2010;2:167-180.155. Schlapbach LJ, Kessler U, Thiel S, Hansen AG, Nelle M, Ammann RA, Aebi C, Jensenius JC. M-ficolin in the neonatal period: Associations with need for mechanical ventilation and mortality in premature infants with necrotising enterocolitis. Mol Immunol. 2009, 46:2597-603.156. Degn, S. E., Hansen, A. G., Steffensen, R., Jacobsen, C., Jensenius, J. C., Thiel, S. MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. J. Immunol., 2009, 183(11):7371-7378.157. Chaouat G, Petitbarat M, Bulla R, Dubanchet S, Valdivia K, Ledée N, Thiel S, Jensenius JC, Tedesco F. Early regulators in abortion and implications for a preeclampsia model. J Reprod Immunol. 2009, 82:131-40.158. Henić E, Thiel S, Mårdh PA.Mannan-binding lectin in women with a history of recurrent vulvovaginal candidiasis., Eur J Obstet Gynecol Reprod Biol., 2009,148:163-5.159. Schlapbach LJ, Mattmann M, Thiel S, Boillat C, Otth M, Nelle M, Wagner B, Jensenius JC, Aebi C. Differential role of the lectin pathway of complement activation in susceptibility to neonatal sepsis. Clin Infect Dis. 2010;51(2):153-62160. Degn SE, Jensen L, Gál P, Dobó J, Holmvad SH, Jensenius JC, Thiel S. Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system. J Immunol Methods. 2010, 361(1-2):37-50.161. Louise Carstensen Gjelstrup, Thomas Boesen, Tue Wenzel Kragstrup, Annette Jørgensen, Nigel J. Klein, Steffen Thiel, Bent Winding Deleuran, and Thomas Vorup-Jensen Shedding of Large Functionally Active CD11/CD18 Integrin Complexes from Leukocyte Membranes during Synovial Inflammation Distinguishes Three Types of Arthritis through Differential Epitope Exposure. J. Immunol., 2010, 185(7):4154-68.162. Schlapbach LJ, Thiel S, Kessler U, Ammann RA, Aebi C, Jensenius JC. Congenital H-ficolin deficiency in premature infants with severe necrotizing enterocolitis. Gut. 2011, 60(10):1438-9.163. Schlapbach LJ, Thiel S, Aebi C, Hirt A, Leibundgut K, Jensenius JC, Ammann RA. M-ficolin in children with cancer. Immunobiology. 2011, 216(5):633-8.164. Chang WC, White MR, Moyo P, McClear S, Thiel S, Hartshorn KL, Takahashi K. Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection. BMC Immunol. 2010;11(1):64.165. Ytting H, Christensen IJ, Steffensen R, Alsner J, Thiel S, Jensenius JC, Hansen U, Nielsen HJ. Mannan-Binding Lectin (MBL) and MBL-Associated Serine Protease 2 (MASP-2) Genotypes in Colorectal Cancer. Scand J Immunol. 2011, 73(2):122-7.166. Ostergaard JA, Thiel S, Hansen TK, Rasch R, Flyvbjerg A. Comment on: Lin et al. (2010) Immune Cell-Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin. Diabetes. 2011, 60(1):e7-8.167. Sallenbach S, Thiel S, Aebi C, Otth M, Bigler S, Jensenius JC, Schlapbach LJ, Ammann RA. Serum concentrations of lectin-pathway components in healthy neonates, children and adults: mannan-binding lectin (MBL), M-, L-, and H-ficolin, and MBL-associated serine protease-2 (MASP-2). Pediatr Allergy Immunol. 2011, 22(4):424-30.168. Brinkmann CR, Thiel S, Larsen MK, Petersen TE, Jensenius JC, Heegaard CW. Preparation and comparison of cytotoxic complexes formed between oleic acid and either bovine or human α-lactalbumin. J Dairy Sci. 2011, 94(5):2159-70.169. Clemons KV, Martinez M, Axelsen M, Thiel S, Stevens DA. Efficacy of Recombinant Human Mannose Binding Lectin Alone and in Combination with Itraconazole Against Murine Candida albicans vaginitis. Immunol Invest. 2011, 40(6):553-68. 170. Ammitzboll CG, Thiel S, Ellingsen T, Deleuran B, Jorgensen A, Jensenius JC, Stengaard-Pedersen K. Levels of lectin pathway proteins in plasma and synovial fluid of rheumatoid arthritis and osteoarthritis. Rheumatol Int. 2011;32(5):1457-63.171. Brinkmann CR, Heegaard CW, Petersen TE, Jensenius JC, Thiel S. The toxicity of BAMLET is highly dependent on oleic acid and induces killing in cancer cell lines and non-cancer derived primary cells. FEBS J. 2011, 278(11):1955-67.172. Boldt AB, Grisbach C, Steffensen R, Thiel S, Kun JF, Jensenius JC, Messias-Reason IJ. Multiplex sequence-specific polymerase chain reaction reveals new MASP2 haplotypes associated with MASP-2 and MAp19 serum levels. Hum Immunol. 2011 ;72(9):753-60.173. Degn SE, Thiel S, Nielsen O, Hansen AG, Steffensen R, Jensenius JC. MAp19, the alternative splice product of the MASP2 gene. J Immunol Methods. 2011, 373(1-2):89-101.174. Gjelstrup LC, Andersen SH, Petersen SV, Enghild JJ, Blom AM, Vorup-Jensen T, Thiel S. The role of higher-order protein structure in supporting binding by heteroclitic monoclonal antibodies: The monoclonal antibody KIM185 to CD18 also binds C4-binding protein. Mol Immunol. 2011;49(1-2):38-47.175. Bernth-Jensen JM, Møller BK, Jensenius JC, Thiel S. Biological variation of anti-αGal-antibodies studied by a novel Time-Resolved ImmunoFluorometric Assay. J Immunol Methods. 2011, 373(1-2):26-35.176. Degn SE, Andersen SH, Jensen L, Thiel S, Jensenius JC. Assay interference caused by antibodies reacting with rat kappa light-chain in human sera. J Immunol Methods. 2011 30;372(1-2):204-8.177. Kjaer TR, Hansen AG, Sørensen UB, Nielsen O, Thiel S, Jensenius JC. Investigations on the pattern recognition molecule M-ficolin: quantitative aspects of bacterial binding and leukocyte association. J Leukoc Biol. 2011 ;90(3):425-437.178. Ovesen T, Kragelund JR, Jensen JM, Thiel S, Veirum JE. Immunodeficiencies in children with chronic post tympanic otorrhoea. Dan Med Bull. 2011;58(7):A4282179. Degn SE, Jensenius JC, Thiel S. Disease-causing mutations in genes of the complement system. Am J Hum Genet. 2011;88(6):689-705.180. Gjelstrup LC, Kaspersen JD, Behrens MA, Pedersen JS, Thiel S, Kingshott P, Oliveira CL, Thielens NM, Vorup-Jensen T. The role of nanometer-scaled ligand patterns in polyvalent binding by large mannan-binding lectin oligomers. J Immunol. 2012;188(3):1292-306.181. Ameye L, Paesmans M, Thiel S, Jensenius JC, Aoun M. M-ficolin levels are associated with the occurrence of severe infections in patients with haematological cancer undergoing chemotherapy. Clin Exp Immunol. 2012;167(2):303-8.182. Zacho RM, Jensen L, Terp R, Jensenius JC, Thiel S. Studies of the pattern recognition molecule H-ficolin: specificity and purification. J Biol Chem. 2012;287(11):8071-81.183. Mellbin LG, Bjerre M, Thiel S, Hansen TK. Complement Activation and Prognosis in Patients With Type 2 Diabetes and Myocardial Infarction: A report from the DIGAMI 2 trial. Diabetes Care. 2012;35(4):911-7.184. Thiel, S; Jensen, L; Degn, S; Nielsen, H; Gál, P; Dobó, J; Jensenius, J. Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components. Clin Exp Immunol, 2012;169(1):38-48. 185. Ostergaard JA, Bjerre M, Ramachandrarao SP, Sharma K, Nyengaard JR, Hansen TK, Thiel S, Flyvbjerg A. Mannan-binding lectin in diabetic kidney disease: the impact of mouse genetics in a type 1 diabetes model. Exp Diabetes Res. 2012, 2012:678381.186. Petersen T, Møller-Larsen A, Ellermann-Eriksen S, Thiel S, Christensen T. Effects of interferon-beta therapy on elements in the antiviral immune response towards the human herpesviruses EBV, HSV, and VZV, and to the human endogenous retroviruses HERV-H and HERV-W in multiple sclerosis. J Neuroimmunol. 2012 ;249(1-2):105-8.187. Foldager, Leslie; Steffensen, Rudi; Thiel, Steffen; Als, Thomas Damm; Nielsen, Hans Jørgen; Nordentoft, Merete; Mortensen, Preben Bo; Mors, Ole; Jensenius, Jens Christian. MBL and MASP-2 concentrations in serum and MBL2 promoter polymorphisms are associated to schizophrenia. Acta Neuropsychiatrica, 2012, 24(4), 199-207.188. Schlapbach LJ, Kjaer TR, Thiel S, Mattmann M, Nelle M, Wagner BP, Ammann RA, Aebi C, Jensenius JC. M-ficolin concentrations in cord blood are related to circulating phagocytes and to early-onset sepsis. Pediatr Res. 2012;71(4 Pt 1):368-74.189. Schlapbach LJ, Woerner A, Thiel S, Ammann RA, Aebi C, Nelle M, Jensenius JC. Goood agreement between capillary and venous sampling for lectin pathway proteins. Immunobiology. 2013;218(4):465-9190. Reichhardt MP, Loimaranta V, Thiel S, Finne J, Meri S, Jarva H. The salivary scavenger and agglutinin binds MBL and regulates the lectin pathway of complement in solution and on surfaces. Front Immunol. 2012;3:205. doi: 10.3389/fimmu.2012.00205191. Verma A, White M, Vathipadiekal V, Tripathi S, Mbianda J, Ieong M, Qi L, Taubenberger JK, Takahashi K, Jensenius JC, Thiel S, Hartshorn KL. Human H-Ficolin Inhibits Replication of Seasonal and Pandemic Influenza A Viruses. J Immunol. 2012;189(5):2478-87.192. Søren Degn, Lisbeth Jensen, Annette Hansen, Duygu Duman, Mustafa Tekin, Jens C. Jensenius, Steffen Thiel. MASP-1 is crucial for lectin pathway activation in human serum, while neither MASP-1 nor MASP-3 are required for alternative pathway function. J Immunology 2012;189(8):3957-69.193. Boldt AB, Sanchez MI, Stahlke ER, Steffensen R, Thiel S, Jensenius JC, Prevedello FC, Mira MT, Kun JF, Messias-Reason IJ. Susceptibility to Leprosy is Associated with M-ficolin Polymorphisms. J Clin Immunol. 2012, 33(1):210-9.194. Kidmose RT, Laursen NS, Dobó J, Kjaer TR, Sirotkina S, Yatime L, Sottrup-Jensen L, Thiel S, Gál P, Andersen GR. Structural basis for activation of the complement system by component C4 cleavage. Proc Natl Acad Sci U S A. 2012;109(38):15425-30195. Grönwall C, Chen Y, Vas J, Khanna S, Thiel S, Corr M, Kono DH, Silverman GJ.MAPK phosphatase-1 is required for regulatory natural autoantibody-mediated inhibition of TLR responses. Proc Natl Acad Sci U S A. 2012;109(48):19745-50.196. Høyem PH, Bruun JM, Pedersen SB, Thiel S, Richelsen B, Christiansen JS, Hansen TK. The effect of weight loss on serum mannose-binding lectin levels. Clin Dev Immunol. 2012:354894.197. Ammitzbøll CG, Kjær TR, Steffensen R, Stengaard-Pedersen K, Nielsen HJ, Thiel S, Bøgsted M, Jensenius JC. Non-Synonymous Polymorphisms in the FCN1 Gene Determine Ligand-Binding Ability and Serum Levels of M-Ficolin. PLoS One. 2012;7(11):e50585.198. Kjaer TR, Hansen AG, Sørensen UB, Holm AT, Sørensen GL, Jensenius JC, Thiel S. M-ficolin binds selectively to the capsular polysaccharides of Streptococcus pneumoniae serotypes 19B and 19C and of a S. mitis strain. Infect Immun. 2012, 81(2):452-9.199. Takahashi, Kazue; and Thiel, Steffen (2013) Ficolins. In: eLS.John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0021209.pub2200. Thiel, Steffen; and Takahashi, Kazue (2013) Collectins. In: eLS.John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0003659.pub3201. Degn SE, Thiel S, Jensenius JC. Recombinant expression of the autocatalytic complement protease MASP-1 is crucially dependent on co-expression with its inhibitor, C1 inhibitor. Protein Expr Purif. 2013, 88(2):173-82.202. Egli A, Schäfer J, Osthoff M, Thiel S, Mikkelsen C, Rauch A, Hirsch HH, Bucher HC, Young J, Jensenius JC, Battegay M, Trendelenburg M; the Swiss HIV Cohort Study. Low Levels of Mannan-Binding Lectin or Ficolins Are Not Associated with an Increased Risk of Cytomegalovirus Disease in HIV-Infected Patients. PLoS One. 2013;8(1):e51983.203. Ostergaard JA, Bjerre M, Dagnaes-Hansen F, Hansen TK, Thiel S, Flyvbjerg A. Diabetes-induced changes in mannan-binding lectin levels and complement activation in a mouse model of type 1 diabetes. Scand J Immunol. 2013, 77(3):187-94.204. Brinkmann CR, Jensen L, Dagnaes-Hansen F, Holm IE, Endo Y, Fujita T, Thiel S, Jensenius JC, Degn SE. Mitochondria and the lectin pathway of complement. J Biol Chem. 2013, 288(12):8016-27.205. Brinkmann CR, Thiel S, Otzen DE. Protein:fatty acid complexes: Biochemistry, biophysics and function. FEBS J. 2013. 280(8):1733-49.206. Joseph K, Kulik L, Coughlin B, Kunchithapautham K, Bandyopadhyay M, Thiel S, Thielens NM, Holers VM, Rohrer B. Oxidative Stress Sensitizes RPE Cells to Complement-Mediated Injury in a Natural Antibody-, Lectin Pathway- and Phospholipid Epitope-Dependent Manner. J Biol Chem. 2013, 288(18):12753-65.207. Frauenknecht V, Thiel S, Storm L, Meier N, Arnold M, Schmid JP, Saner H, Schroeder V. Plasma levels of mannan-binding lectin (MBL)-associated serine proteases (MASPs) and MBL-associated protein in cardio- and cerebrovascular diseases. Clin Exp Immunol. 2013;173(1):112-20.208. Response to comment on "mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function". Degn SE, Jensenius JC, Thiel S. J Immunol. 2013;190(6):2477-8.209. Christel Rothe Brinkmann, André Brodkorb, Steffen Thiel and Joseph J. Kehoe. The cytotoxicity of fatty acid/α-lactalbumin complexes depends on the amount and type of fatty acid European Journal of Lipid Science and Technology 2013, , DOI:10.1002/ejlt.201200165210. Degn SE, Thiel S. Humoral pattern-recognition and the complement system. Scand J Immunol. 2013;78(2):181-93211. Kjaer TR, Thiel S, Andersen GR. Toward a structure-based comprehension of the lectin pathway of complement. Mol Immunol. 2013;56(4):413-422212. Boldt AB, Goeldner I, Stahlke ER, Thiel S, Jensenius JC, de Messias-Reason IJ. Leprosy Association with Low MASP-2 Levels Generated by MASP2 Haplotypes and Polymorphisms Flanking MAp19 Exon 5. PLoS One. 2013 Jul 30;8(7):e69054.213. Axelgaard E, Jensen L, Dyrlund TF, Nielsen HJ, Enghild JJ, Thiel S, Jensenius JC.Investigations on collectin liver 1. J Biol Chem. 2013;288(32):23407-20214. Degn SE, Jensen L, Olszowski T, Jensenius JC, Thiel S. Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44. J Immunol. 2013;191(3):1334-45215. Gytz Ammitzbøll C, Steffensen R, Jørgen Nielsen H, Thiel S, Stengaard-Pedersen K, Bøgsted M, Jensenius JC. Polymorphisms in the MASP1 Gene Are Associated with Serum Levels of MASP-1, MASP-3, and MAp44. PLoS One. 2013 Sep 2;8(9):e73317216. Ammitzbøll CG, Thiel S, Jensenius JC, Ellingsen T, Hørslev-Petersen K, Hetland ML, Junker P, Krogh NS, Ostergaard M, Stengaard-Pedersen K. M-ficolin reflects disease activity and predicts remission in early rheumatoid arthritis. Arthritis Rheum. 2013;65(12):3045-50.217. Sandahl TD, Kelsen J, Dige A, Dahlerup JF, Agnholt J, Hvas CL, Thiel S. The lectin pathway of the complement system is downregulated in Crohn's disease patients who respond to anti-TNF-α therapy. J Crohns Colitis. 2013. pii: S1873-9946(13)00396-6218. Ingels C, Vanhorebeek I, Steffensen R, Derese I, Jensen L, Wouters PJ, Hermans G, Thiel S, Van den Berghe G. Lectin pathway of complement activation and relation with clinical complications in critically ill children. Pediatr Res. 2014;75(1-1):99-108.219. Holt CB, Thiel S, Munk K, Ostergaard JA, Bøtker HE, Hansen TK Association between endogenous complement inhibitor and myocardial salvage in patients with myocardial infarction. Eur Heart J Acute Cardiovasc Care. 2014;3(1):3-9220. Megyeri M, Jani PK, Kajdácsi E, Dobó J, Schwaner E, Major B, Rigó J Jr, Závodszky P, Thiel S, Cervenak L, Gál P. Serum MASP-1 in complex with MBL activates endothelial cells. Mol Immunol. 2014;59(1):39-45.221. Foldager L, Köhler O, Steffensen R, Thiel S, Kristensen AS, Jensenius JC, Mors O.Bipolar and panic disorders may be associated with hereditary defects in the innate immune system. J Affect Disord. 2014;164:148-54.222. Degn SE, Jensenius JC, Thiel S. The Pro-Factor D Cleaving Activity of MASP-1/-3 Is Not Required for Alternative Pathway Function. J Immunol. 2014;192(12):5447-8.223. Dwyer M, Shan Q, D'Ortona S, Maurer R, Mitchell R, Olesen H, Thiel S, Huebner J, Gadjeva M. Cystic Fibrosis Sputum DNA Has NETosis Characteristics and Neutrophil Extracellular Trap Release Is Regulated by Macrophage Migration-Inhibitory Factor.J Innate Immun. 2014; 6(6):765-79.224. Ostergaard JA, Thiel S, Hovind P, Holt CB, Parving HH, Flyvbjerg A, Rossing P, Hansen TK. Association of the pattern recognition molecule H-ficolin with incident microalbuminuria in an inception cohort of newly diagnosed type 1 diabetic patients: an 18 year follow-up study. Diabetologia. 2014 Jul 28.225. Sandahl TD, Grønbæk H, Møller HJ, Støy S, Thomsen KL, Dige AK, Agnholt J, Hamilton-Dutoit S, Thiel S, Vilstrup H. Hepatic Macrophage Activation and the LPS Pathway in Patients With Alcoholic Hepatitis: A Prospective Cohort Study. Am J Gastroenterol. 2014; 109(11):1749-56.226. Laursen TL, Sandahl TD, Støy S, Schiødt FV, Lee WM, Vilstrup H, Thiel S, Grønbaek H; US Acute Liver Failure Study Group. Circulating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure. Liver Int. 2014. Liver Int. 2015 Mar;35(3):756-63.227. Kelsen J, Sandahl TD, Storm L, Frings-Meuthen P, Dahlerup JF, Thiel S. Changes in the levels of mannan-binding lectin and ficolins during head-down tilted bed rest. Aviat Space Environ Med. 2014; 85(8):805-11.228. Ostergaard JA, Thiel S, Hovind P, Holt CB, Parving HH, Flyvbjerg A, Rossing P, Hansen TK. Association of the pattern recognition molecule H-ficolin with incident microalbuminuria in an inception cohort of newly diagnosed type 1 diabetic patients: an 18 year follow-up study. Diabetologia. 2014; 57(10):2201-7. 229. Storm L, Christensen IJ, Jensenius JC, Nielsen HJ, Thiel S; the Danish Study Group on Early Detection of Colorectal Cancer. Evaluation of complement proteins as screening markers for colorectal cancer. Cancer Immunol Immunother. 2015; 64(1):41-50.230. Smedbråten YV, Sagedal S, Mjøen G, Hartmann A, Fagerland MW, Rollag H, Mollnes TE, Thiel S. High Ficolin-3 Level at the Time of Transplantation Is an Independent Risk Factor for Graft Loss in Kidney Transplant Recipients. Transplantation. 2015 Apr;99(4):791-6.231. Degn SE, Kjaer TR, Kidmose RT, Jensen L, Hansen AG, Tekin M, Jensenius JC, Andersen GR, Thiel S. Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes. Proc Natl Acad Sci U S A. 2014;111(37):13445-50.232. Banda NK, Mehta G, Kjaer TR, Takahashi M, Schaack J, Morrison TE, Thiel S, Arend WP, Holers VM. Essential role for the lectin pathway in collagen antibody-induced arthritis revealed through use of adenovirus programming complement inhibitor MAp44 expression. J Immunol. 2014;193(5):2455-68.233. Jenny L, Ajjan R, King R, Thiel S, Schroeder V. Plasma Levels of MASP-1 and MASP-2 are Elevated in Type 1 Diabetes and Correlate with Glycaemic Control. Clin Exp Immunol. 2014. doi: 10.1111/cei.12574. [Epub ahead of print]234. Troels R. Kjaer, Le T. M. Le, Jan Skov Pedersen, Bjoern Sander, Monika M. Golas, Jens Christian Jensenius, Gregers R. Andersen and Steffen Thiel. Structural insights into the initiating complex of the lectin pathway of complement activation, Structure, 2015. pii: S0969-2126(14)00407-9.235. Rafael B. Olmos, Soren Hansen, Maiken L. Henriksen, Line Storm, Steffen Thiel, Peter Garred, Lea Munthe-Fog. Genetic variation of COLEC10 and COLEC11 and association with the corresponding serum levels of Collectin liver 1 (CL-L1) and Collectin kidney 1 (CL-K1). 2015 Plos One, Feb 24;10(2):e0114883.236. Østergaard JA, Thiel S, Lajer M, Steffensen R, Parving HH, Flyvbjerg A, Rossing P, Tarnow L, Hansen TK. Increased All-Cause Mortality in Patients With Type 1 Diabetes and High-Expression Mannan-Binding Lectin Genotypes: A 12-Year Follow-up Study.Diabetes Care. 2015 Jul 15. pii: dc150851. [Epub ahead of print]237. Troldborg A, Thiel S, Jensen L, Hansen S, Laska MJ, Deleuran B, Jensenius JC, Stengaard-Pedersen K CL-L1 and CL-K1 and other complement associated pattern recognition molecules in systemic lupus erythematosus. Clin Exp Immunol. 2015 Jul 7. doi: 10.1111/cei.12678.238. Petri C, Thiel S, Jensenius JC, Herlin T. Investigation of Complement-activating Pattern Recognition Molecules and Associated Enzymes as Possible Inflammatory Markers in Oligoarticular and Systemic Juvenile Idiopathic Arthritis. J Rheumatol. 2015 Jul;42(7):1252-8. 239. Troldborg A, Thiel S, Laska MJ, Deleuran B, Jensenius JC, Stengaard-Pedersen K. Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus. J Rheumatol. 2015 Jun;42(6):948-51. doi: 10.3899/jrheum.141163. Epub 2015 Apr 15. Book chapters:Mihaela Gadjeva, Steffen Thiel and Jens C. Jensenius. Assays for Mannan Binding Lectin Pathway. Current protocols in Immunology. 2004, Wiley, Chapter 13:Unit 13.6.Mihaela Gadjeva, Steffen Thiel. Evaluation of the Lectin Pathway of Complement Activation. Manual of Molecular and Clinical Laboratory Immunology, 7th edition. Edited by Barbara Detrick, May, 2006.Steffen Thiel, Mihaela Gadjeva. Humoral Pattern Recognition Molecules: Mannan-Binding Lectin and Ficolins. Chapter 6, in; “TARGET PATTERN RECOGNITION IN INNATE IMMUNITY”, Edited by Uday Kishore: Landes Bioscience, Advances in Experimental Medicine and Biology, Vol. 653, 2009.Mette Møller-Kristensen, Steffen Thiel, Jens Chr. Jensenius, MBL polymorphisms and infectious diseases, in “Animal lectins: A functional view”, CRC Press, Taylor and Francis Group, 303-332, 2009.Kjaer TR, Thiel S. Assay for estimation of the functional activity of the mannan-binding lectin pathway of the complement system. Methods Mol Biol. 2014;1100:131-9Patenter og patentansøgninger.Jensenius, J.C. and Thiel, S. "MASP-2, a complement-fixing enzyme and uses for it". U.S. SERIAL NO. 09/054,218 (09/874,198 og 09/874,238). Filing date USA, 04/02/98. 4 Figs. 96 claims, 66 pages. PCT/DK01/00499 (WO 02/06460Thomas Vorup Jensen, Steffen Thiel and Jens C. Jensenius: "Recombinant human mannan-binding lectin. DK- PA 1999 00668. Filing date DK, 14.05.99. 52 pgs.,5 Fig. 59 claims. PCY/DK00/00246; USA 09/568,143.Jens Christian Jensenius, Steffen Thiel: "MASP-3: an MBL-associated serine protease and uses for it". DK- PA 1999 01721. Filing date Dec. 02, 1999; PCT/DK 00/00659 (WO 01/40451), USA 10/148,671; 76 pgs., 10 figs; 10 pgs sequences, 68 claims.Jens Christian Jensenius and Steffen Thiel: "Novel indications of mannan-binding lectin (MBL) in the treatment of immuno-compromized individuals". Danish patent application PA1999 01508. Filing date 20/10 1999; US app. no.09/568,142; PTC/DK00/00246. 29 pgs., 2 figs, 47 claims. US 2007/0197428 A1Steffen Thiel, Jens Christian Jensenius, Lars Fugger and Kristian Stengaard-Pedersen: "Method for determining predisposition to manifestation of immune system related diseases" (MASP-2 mutation). DK PA 2002 01867, PA 2002 01892, PA 2003 00742, May 15 2003; 63 pgs, 4 figs, 10 pgs sequences, 44 claims.Mette Møller-Kristensen, Steffen Thiel and Jens Christian Jensenius: "Antibodies to MASP-2", app. May 12, 2003, PA 2003 00716.Greta van der Berghe, Steffen Thiel, Troels Hansen. Methods and preparations for curing critically ill patients. US2006122102. 2006-06-08. US2009/0181882 A1Steffen Thiel, Søren Degn, Jens Jensenius: HOMEOSTATIC MULTIDOMAIN PROTEIN, AND USES FOR IT. US 2012/0122107 A1SARMA PURANAM USHA, GUPTA TARUNA MADAN, KAUR SAVNEET, THIEL STEFFEN (DK). PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF INVASIVE PULMONARY ASPERGILLOSIS. WO2006067807. 2006-06-29. EP 1833502 (A1)Indications of mannan-binding lectin (MBL) in the treatment of immunocompromised individuals. Patent number: 6562784. US 6,362,784 B1. May 13, 2003 Andre aktiviteter:Undervisningsaktivitet:Underviser ved kursus i medicinsk mikrobiologi og immunologi for 2.dels medicinstu¬derende, Århus Universitet.Underviser ved Ph.D. kursus (Immunology), Eötvös Loránd University, Budapest, Ungarn, ved Ph.D. kursus (Glycobiology Course), Københavns Universitet, og ved Ph.D. kursus (Molekylær Immunologi), Århus Universitet.Organisator og ledende underviser af kurset ”Aspekter af erhvervet og medfødt immunforsvar” (C-modul) og kurset ”Immunologi” (B-modul) ved Aarhus Universitet, Naturvidenskabelig Fakultet. Administrative aktiviteter:Medlem af bestyrelsen siden 1994 ved Institut for Medicinsk Mikrobiologi og Immunologi, Århus Universitet. Stedfortræder for institutleder fra 1998.Sikkerhedschef for Bartholinbygningen, Århus Universitet fra 1998-2001.Formand for Immunologisk Selskab, Danmark, fra 2007.Member of editorial board of Immunobiology og Scandinavian Journal of Immunology og referee på artikler fra andre tidskrifter.Board member of European Complement Network, fra 2013.Bedømmer af ansøgninger til Biotechnology and Biological Science Research Council, UK, og Cancer Research Fund, UK.Bedømmer af adjunkt og lektorstillinger ved Københavns Universitet, Syddansk Universitet og Århus Universitet og professorstillinger ved Københavns Universitet.Mødeaktiviteter:Aktivt deltagende med abstracts og foredrag ved en række møder og kon¬ferencer i årerne fra 1986 til nu.Chairman ved "Fourth European Meeting on Complement in Human Disease", Leiden, Holland, 1992, ved "IVth International workshop on C1 and collectins", Mainz, Tyskland, 1997, ved ”11th International Congress of Immunology”, Stockholm, 2001, ved “36. Annual Meeting of the German Society of Immunology”, Kiel, 2005, ved "VIth International workshop on C1 and collectins", Seeheim, Tyskland, 2006, ved 37th Scandinavian Society for Immunology Meeting, Turku, Finland, 2007 og ved 2nd European Congress of Immunology, Berlin, 2009.Foredragsholder i 2014 ved: Innate Immunity Summit, London (10-12. November) og ved XXV International Complement Workshop, Rio de Janeiro (September 14-18).Medorganisator af "Scandinavian Society for Immunology, XXIVth annual meeting and IX summer school", Århus, Maj 1993. Præsident for "Scandinavian Society for Immunology, 35th annual meeting and 21th summer school", Århus, juni 2004. Organisator af “Danish Immunological Society, Annual Meeting 2006”, Århus, maj 2006.Censoraktivitet:Censor ved eksaminer i Immunologi for 2.dels biokemi og biologi stu¬derende ved Københavns Universitet. Censor ved eksaminer i Immunologi for 2.dels cellebiologi studerende ved Odense Universitet. Censor ved eksaminer i Biokemi for 2. dels biokemi/biologi/bioteknologi studerende ved Århus UniversitetCensor for cand. scient. specialer fra Odense Universitet og fra Aarhus Universitet.Censor for PhD afhandlinger ved Syddansk Universitet, Københavns Universitet og Aarhus Universitet og medicinsk doktorafhandling fra Aarhus Universitet.Censor for doktorafhandlinger fra Oxford Universitet, England, fra Reykjavik Universitet, Island og fra National University of Singapore, Singapore.Erhversrettet virksomhed:Stifter af Biotekvirksomhederne NatImmune A/S og Helion Biotech A/S. Tilknyttet som bestyrelsesmedlem i perioder i begge selskaber.Priser:Modtager Hanstedgaardsfondens pris januar 2013.