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Institut for Biomedicin

Olav Michael Andersen

Lektor

Olav Michael Andersen
Lektor
Institut for Biomedicin - Forskning og uddannelse, Vest
Ole Worms Allé 3, 1171, 220
8000, Aarhus C
Danmark
E-mail: o.andersen@biokemi.au.dk
Telefon: 87167786
Mobil: 20370740

Uddannelse

2002	Ph.D i molekylær biologi, Aarhus Universitet, Danmark. Titel: "Preferential ligand binding to lipoprotein receptors"
1997	Kandidat i Kemi-Bioteknologi, Aarhus Universitet, Danmark

Karriere indenfor forskning

2013-	Medlem af redaktionen på “Receptors & Clinical Investigation”
2011 -	Lektor, Biomedicin, Health, Aarhus Universitet, Danmark
2008-2011	Adjunkt institut for medicinsk biokemi, Health, Aarhus Universitet
2007-2008	Post.doc., institut for medicinsk biokemi, Health, Aarhus Universitet
2001-2007	Post.doc.,Max-Delbrück-Center for Molecular Medicine, Berlin, Tyskland
1997-2001	PhD studerende, institut for molekylær biologi, fakultetet Sciences, aarhus Universitet
2000	Besøgende forsker på Center for Advanced Research in Biotechnology, National Institute of Standards and Technology, Maryland, USA
1998	EMBO sommerskole, "Ligand-Receptor interactions, Analysis by Integrated Advarnced Methods" , Bologna, Italien
1998	FEBS sommerskole, "New strategies and Methods in Protein research", Urbino, Italien

Priser

BIAcore Science Award 2004, Tyskland

Udvalgte Foredrag

2012	Inviteret taler påInvited speaker at The 32nd Annual Meeting of the Australian Neuroscience Society, guldkysten, Australien: “Identification of amino acids in sorLA that influence APP processing and protects against Alzheimer’s disease”
2010	Taler på den 11th International Conference on Alzheimer’s disease and Related Disorders, Honolulu, USA: “The role of retromer in sorLA-dependent processing of APP”
2009	inviteret taler på The 29th Australian Neuroscience Society Meeting, Canberra, Australien: “The Role of sorLA/LR11 in Amyloid Precursor Protein Metabolism”. Bliver som følge heraf interviewet af Australske medier
2007	Inviteret taler ved seminarer på Biocenteret Københavns Universitet, Danmark: “The role of sorLA/LR11 in APP transport and Alzheimer's disease”.
2006	Foredrag på Wollenberger, MDC-Berlin, Tyskland: ”A desicive role for sorLA in amyloid protein precursor metabolism”
2005	inviteret foredrags holder institut for molekylær biologi,Københavns Universitet, Danmark: “SorLA, a neuronal sorting receptor for amyloid protein precursor”
2005	Taler på det 7th Internationalt møde på ADPD i Sorrento, Italien: “SorLA, a neuronal sorting receptor for amyloid protein precursor”
2004	Indbudt taler hos Biacore, Göttingen, Tyskland: “Differential binding of ligands to the apolipoprotein E receptor 2”
2004	The Butterfly Seminarium, MDC-Berlin, Tyskland: “SorLA, a neuronal sorting receptor for APP”.
2003	The Wollenberger Seminarium, MDC-Berlin, Tyskland. “A novel lipoprotein receptor with a proposed role in APP metabolism”.
2003	Indbudt taler, hos Eli Lilly, Indianapolis, USA: “SorLA - A brain receptor with a proposed role in APP metabolism”.

Bibliometrisk data

32 peer reviewed publikationer (13 som 1 forfatter og 7 som sidste forfatter 1 kapitet i bog,1 patent

H-index 15 (Scopus; total antal af citater 1000)

Kapitler i bøger

2008	Lipoprotein receptors in Alzheimer’s disease, in “Research Progress in Alzheimer’s Disease and Dementia; Forfatter: Olav M. Andersen and Thomas E. Willnow Forlag: Nova Publishers

Patenter

2008	Modulation of activity of neurotrophins Patent #200601692. Ansøgere: Olav M. Andersen and Anders Nykjær

Udgivelser

20 Years Anniversary for SORLA/SORL1 (1996-2016)

Monti, G. & Andersen, O. M. dec. 2017 I : Receptors and Clinical Investigation. 4, 4, s. 2-10 e1611

Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease

Andersen, O. M., Rudolph, I-M. & Willnow, T. E. 16 sep. 2016 I : Acta Neuropathologica. 132, 5, s. 653–665 9 s.

SorCS2 is required for BDNF-dependent plasticity in the hippocampus

Glerup, S., Bolcho, U., Bøggild, S., Vaegter, C. B., Smith, A. H., Nieto-Gonzalez, J. L., Ovesen, P. L., Pedersen, L. F., Fjorback, A. N., Kjolby, M., Login, H., Holm, M. M., Andersen, O. M., Nyengaard, J. R., Willnow, T. E., Jensen, K., Nykjaer, A. & Jensen, S. M. 2016 I : Molecular Psychiatry.

The A-B-C for SORting APP

Coulson, E. J. & Andersen, O. M. okt. 2015 I : Journal of Neurochemistry. 135, 1, s. 1-3 3 s.

Mutants of Metal Binding Site M1 in APP E2 Show Metal Specific Differences in Binding of Heparin but Not of sorLA

Dienemann, C., Coburger, I., Mehmedbasic, A., Andersen, O. M. & Than, M. E. 10 apr. 2015 I : Biochemistry.

SorLA CR-Domains Protect the Amyloid Precursor Protein against Processing

Mehmedbasic, A., Christensen, S. K., Nilsson, J., Rüetschi, U., Gustafsen, C., Poulsen, A. S. A., Rasmussen, R. W., Fjorback, A. N., Larson, G. & Andersen, O. M. 18 dec. 2014 I : Journal of Biological Chemistry.

New Horizons for Lipoprotein ReceptorsCommunication by β-propellers

Andersen, O. M., Dagil, R. & Kragelund, B. B. okt. 2013 I : Journal of Lipid Research. 54(10), s. 2763- 2774 11 s.

Sorting receptor SORLA - a trafficking path to avoid Alzheimer disease

Willnow, T. E. & Andersen, O. M. 1 jul. 2013 I : Journal of Cell Science. 126, Pt 13, s. 2751-60 10 s.

Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein

Gustafsen, C., Glerup, S., Pallesen, L. T., Olsen, D., Andersen, O. M., Nykjær, A., Madsen, P. & Petersen, C. M. 2013 I : Journal of Neuroscience. 33, 1, s. 64-71 8 s.

SorLA is a molecular link for retromer-dependent sorting of the Amyloid precursor protein

Fjorback, A. W. & Andersen, O. M. 1 nov. 2012 I : Communicative & Integrative Biology. 5, 6, s. 616-9 4 s.

Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing

Fjorback, A. W., Seaman, M., Gustafsen, C., Mehmedbasic, A., Gokool, S., Wu, C., Militz, D., Schmidt, V., Madsen, P., Nyengaard, J. R., E Willnow, T., Christensen, E. I., B Mobley, W., Nykjær, A. & Andersen, O. M. 2012 I : Journal of Neuroscience. 32, 4, s. 1467-1480 14 s.

APP involvement in retinogenesis of mice

Dinet, V., An, N., Ciccotosto, G. D., Bruban, J., Maoui, A., Bellingham, S. A., Hill, A. F., Andersen, O. M., Nykjaer, A., Jonet, L., Cappai, R. & Mascarelli, F. 1 mar. 2011 I : Acta Neuropathologica. 121, 3, s. 351-63 13 s.

The structure of MESD45-184 brings light into the mechanism of LDLR family folding

Köhler, C., Lighthouse, J. K., Werther, T., Andersen, O. M., Diehl, A., Schmieder, P., Du, J., Holdener, B. C. & Oschkinat, H. 2011 I : Structure. 19, 3, s. 337-48 12 s.

Identification of a linear epitope in sortilin that partakes in pro-neurotropin binding

Andersen, O. S., Boisguerin, P., Glerup, S., Skeldal, S., Volkmer, R., Wilnow, T. E., Nykjær, A. & Andersen, O. M. 2010 I : Journal of Biological Chemistry. s. 12210-12222 22 s.

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.

Kjølby, M. F., Andersen, O. M., Breiderhoff, T., Fjorback, A. N., Pedersen, K-M., Madsen, P. S., Jansen, P., Heeren, J., Willnow, T. & Nykjær, A. 2010 I : Cell Metabolism. 12, 3, s. 213-223 11 s.

Interaction of the Apolipoprotein E Receptors low-density lipoprotein receptor related protein and sorLA/LR11

Spoelgen, R., Adams, K. W., Koker, M., Thomas, A. V., Andersen, O. M., Hallet, P. J., Bercury, K. K., Joyner, D. F., Deng, M., Stoothoff, W. H., Strickland, D. K., Willnow, T. E. & Hyman, B. T. 2009 I : Journal of Neuroscience. 158, s. 1460-1468 8 s.

Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: Evidence for a proximal role in Alzheimer's disease

Dodson, S. E., Andersen, O. M., Karmali, V., Fritz, J. J., Cheng, D., Peng, J., Levey, A. I., Wilnow, T. E. & Lah, J. J. 2008 I : The Journal of neuroscience : the official journal of the Society for Neuroscience. 28, s. 12877-12886 9 s.

Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependant stimulation of ERK signalling and adult neurogenesis

Rohe, M., Carlo, A. S., Breyhan, H., Sporbert, A., Millitz, D., Schmidt, V., Wozny, C., Harmeier, A., Erdmann, B., Bales, K. R., Wolf, S., Kempermann, G., Paul, S. M., Schmitz, D., Bayer, T. A., Wilnow, T. E. & Andersen, O. M. 2008 I : Journal of Biological Chemistry. J. Biol Chem, 283, s. 14826-14834 8 s.

Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII.

Sarafanov, A. G., Makagonenko, E. M., Andersen, O., Mikhailenko, I. A., Ananyeva, N. M., Khrenov, A. V., Shima, M., Strickland, D. K. & Saenko, E. L. 2007 I : Thromb. Haemost.. 98, s. 1170-1181 12 s.

SorLA/LR11 regulates processing of the amyloid precursor protein via interactions with adaptors GGA and PACS-1.

Schmidt, V., Sporbert, A., Rohe, M., Reimer, T., Rehm, A., Andersen, O. & Wilnow, T. E. 2007 I : Journal of Biological Chemistry. 282, s. 32956-32964 9 s.

The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family.

Köhler, C., Andersen, O., Diehl, A., Krause, G., Schmieder, P. & Oschkinat, H. 2007 I : J. Struct. Funct. Genom.. 7, s. 131-138 8 s.

Binding site structure of one LRP/RAP complex - Implications for common ligand-receptor binding motif.

Jensen, G. A., Andersen, O., Bonvin, A. M., Bjerrum-Bohr, I., Etzerodt, M., Thøgersen, H. C., O'Shea, B., Poulsen, F. M. & Kragelund, B. B. 2006 I : J. Mol. Biol.. 362, s. 700-716 17 s.

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein and β-secretase, BACE.

Spoelgen, R., Peltan, I. D., Thomas, A. V., Koker, M., von Armin, C. A. F., Deng, A., Andersen, O., Willnow, T. E. & Hyman, B. T. 2006 I : The Journal of neuroscience : the official journal of the Society for Neuroscience. 45, 8, s. 2618-2628 11 s.

Molecular Dissection of the Interaction Between Amyloid Precursor Protein and Its Neuronal Trafficking Receptor SorLA/LR11.

Andersen, O., Schmidt, V., Spoelgen, R., Gliemann, J., Behlke, J., Galatis, D., McKinstry, W. J., Parker, M. W., Masters, C. L., Hyman, B. T., Cappai, R. & Wilnow, T. E. 2006 I : Biochemistry. 45, 8, s. 2618-2628 11 s.

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer's Disease.

Rogaeva, E., Meng, Y., Lee, J. H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C. T., Cheng, R., Hasegawa, H., Chen, F., Shíbata, N., Lunetta, K. L., Pardossi-Piquard, R., Bohm, C., Wakutani, Y., Cupples, L. A., Kuenco, K. T., Green, R. C., Pinessi, L., Rainero, I., Sorbi, S., Bruni, A., Duara, R., Friedland, R., Inzelberg, R., Hampe, W., Bujo, H., Song, Y., Andersen, O., Wilnow, T. E., Graff-Redford, N., Petersen, R. C., Dickson, D., Der, S. D., Fraser, P. E., Ulms, G., Younkin, S., Mayeux, R., Farrer, L. A. & St George-Hyslop, P. 2006 I : Nat. Genet.. 39, s. 168-177 10 s.

LRP2/Megalin is required for patterning of the ventral telencephalon.

Spoelgen, R., Hammes, A., Anzenberger, U., Sechner, D., Andersen, O., Jerchow, B. & Wilnov, T. E. 2005 I : Developement. 132, s. 405-414 9 s.

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Andersen, O., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., Arnim, C. A. V., Breiderhoff, T., Jansen, P., Wu, X., Bales, K. R., Cappai, R., Masters, C. L., Gliemann, J., Mufson, E. J., Hyman, B. T., Paul, S. M., Nykjær, A. & Wilnow, T. E. 2005 I : Proceedings of the National Academy of Sciences of the United States of America. s. 13461-13466 5 s.

Ca²⁺ binding to complement-type repeat domains 5 and 6 from the low density lipoprotein receptor-related protein.

Andersen, O., Vorum, H., Honoré, B. & Thøgersen, H. C. 2003 I : B M C Biochemistry. 4, 1, s. 7-7 1 s.

Differential binding of ligands to the Apolipoprotein E Receptor 2.

Andersen, O., Benhayon, D., Curran, T. & Willnov, T. E. 2003 I : Biochemistry. 42, s. 9355-9364 9 s.

Essential Role of the Apolipoprotein E Receptor-2 in Sperm Development.

Andersen, O., Yeung, C. H., Vorum, H., Wellner, M., Andreassen, T. K., Erdmann, B., Mueller, E. C., Herz, J., Otto, A., Cooper, T. G. & Willnov, T. E. 2003 I : Journal of Biological Chemistry. 278, s. 23989-23995 7 s.

Analysis of a two-domain binding site for the urokinase-type plasminogen activator - plasminogen activator inhibitor-1 complex in low density lipoprotein receptor-related protein,

Andersen, O., Petersen, H. H., Jacobsen, C., Moestrup, S. K., Etzerodt, M., Andreasen, P. & Thøgersen, H. C. 2001 I : Biochem. J.. 357, s. 289-296 8 s.

Dominant thermodynamic role of the third independent receptor binding site in the receptor-associated protein RAP.

Andersen, O., Schwarz, F. P., Eisenstein, E., Jacobsen, C., Moestrup, S. K., Etzerodt, M. & Thøgersen, H. C. 2001 I : Biochemistry. 40, s. 15408-15417 10 s.

Identification of the minimal functional unit in the low density lipoprotein receptor-related protein for binding the receptor-associated protein (RAP)

Christensen, L. L., Christensen, P. A., Sørensen, E. S., Jacobsen, C., Moestrup, S. K., Etzerodt, M., Thøgersen, H. & Andersen, O. 2000 I : Journal of Biological Chemistry. 275, 28, s. 21017-21024 8 s.

Specific Binding of a-Macroglobulin to Complement-type Repeat CR4 of the Low Density Lipoprotein Receptor-related Protein.

Andersen, O., Christensen, P. A., Christensen, L. L., Jacobsen, C., Moestrup, S. K., Etzerodt, M. & Thøgersen, H. C. 2000 I : Biochemistry. 39, 35, s. 10627-10633 7 s.