Olav Michael Andersen

Lektor

Olav Michael Andersen
Lektor
Institut for Biomedicin - Forskning og uddannelse, Vest
Ole Worms Allé 3, 1171, 220
8000, Aarhus C
Danmark
E-mail: o.andersen@biokemi.au.dk
Telefon: 87167786
Mobil: 20370740

Uddannelse

2002Ph.D i molekylær biologi, Aarhus Universitet, Danmark. Titel: "Preferential ligand binding to lipoprotein receptors"
1997Kandidat i Kemi-Bioteknologi, Aarhus Universitet, Danmark

Karriere indenfor forskning

2013- Medlem af redaktionen på “Receptors & Clinical Investigation”
2011 -Lektor, Biomedicin, Health, Aarhus Universitet, Danmark
2008-2011Adjunkt institut for medicinsk biokemi, Health, Aarhus Universitet
2007-2008Post.doc., institut for medicinsk biokemi, Health, Aarhus Universitet
2001-2007Post.doc.,Max-Delbrück-Center for Molecular Medicine, Berlin, Tyskland
1997-2001PhD studerende, institut for molekylær biologi, fakultetet Sciences, aarhus Universitet
2000Besøgende forsker på Center for Advanced Research in Biotechnology, National Institute of Standards and Technology, Maryland, USA
1998EMBO sommerskole, "Ligand-Receptor interactions, Analysis by Integrated Advarnced Methods" , Bologna, Italien
1998FEBS sommerskole, "New strategies and Methods in Protein research", Urbino, Italien

Priser

BIAcore Science Award 2004, Tyskland

Udvalgte Foredrag

2012Inviteret taler påInvited speaker at The 32nd Annual Meeting of the Australian Neuroscience Society, guldkysten, Australien: “Identification of amino acids in sorLA that influence APP processing and protects against Alzheimer’s disease”
2010Taler på den 11th International Conference on Alzheimer’s disease and Related Disorders, Honolulu, USA: “The role of retromer in sorLA-dependent processing of APP”
2009inviteret taler på The 29th Australian Neuroscience Society Meeting, Canberra, Australien: “The Role of sorLA/LR11 in Amyloid Precursor Protein Metabolism”. Bliver som følge heraf interviewet af Australske medier
2007Inviteret taler ved seminarer på Biocenteret Københavns Universitet, Danmark: “The role of sorLA/LR11 in APP transport and Alzheimer's disease”.
2006Foredrag på Wollenberger, MDC-Berlin, Tyskland: ”A desicive role for sorLA in amyloid protein precursor metabolism”
2005inviteret foredrags holder institut for molekylær biologi,Københavns Universitet, Danmark: “SorLA, a neuronal sorting receptor for amyloid protein precursor”
2005Taler på det 7th Internationalt møde på ADPD i Sorrento, Italien: “SorLA, a neuronal sorting receptor for amyloid protein precursor”
2004Indbudt taler hos Biacore, Göttingen, Tyskland: “Differential binding of ligands to the apolipoprotein E receptor 2”
2004The Butterfly Seminarium, MDC-Berlin, Tyskland: “SorLA, a neuronal sorting receptor for APP”.
2003The Wollenberger Seminarium, MDC-Berlin, Tyskland. “A novel lipoprotein receptor with a proposed role in APP metabolism”.
2003Indbudt taler, hos Eli Lilly, Indianapolis, USA: “SorLA - A brain receptor with a proposed role in APP metabolism”.

Bibliometrisk data

32 peer reviewed publikationer (13 som 1 forfatter og 7 som sidste forfatter 1 kapitet i bog,1 patent
H-index 15 (Scopus; total antal af citater 1000)

Kapitler i bøger

2008Lipoprotein receptors in Alzheimer’s disease, in “Research Progress in Alzheimer’s Disease and Dementia; Forfatter: Olav M. Andersen and Thomas E. Willnow Forlag: Nova Publishers

Patenter

2008Modulation of activity of neurotrophins Patent #200601692. Ansøgere: Olav M. Andersen and Anders Nykjær

Udgivelser

New Horizons for Lipoprotein ReceptorsCommunication by β-propellers

Andersen, O. M., Dagil, R. & Kragelund, B. B. okt 2013 I : Journal of Lipid Research. 54(10), s. 2763- 2774 11 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Sorting receptor SORLA - a trafficking path to avoid Alzheimer disease

Willnow, T. E. & Andersen, O. M. 1 jul 2013 I : Journal of Cell Science. 126, Pt 13, s. 2751-60 10 s.

Publikation: Forskning - peer reviewTidsskriftartikel

SorLA is a molecular link for retromer-dependent sorting of the Amyloid precursor protein

Fjorback, A. W. & Andersen, O. M. 1 nov 2012 I : Communicative & Integrative Biology. 5, 6, s. 616-9 4 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing

Fjorback, A. W., Seaman, M., Gustafsen, C., Mehmedbasic, A., Gokool, S., Wu, C., Militz, D., Schmidt, V., Madsen, P., Nyengaard, J. R., E Willnow, T., Christensen, E. I., B Mobley, W., Nykjær, A. & Andersen, O. M. 2012 I : Journal of Neuroscience. 32, 4, s. 1467-1480 14 s.

Publikation: Forskning - peer reviewTidsskriftartikel

APP involvement in retinogenesis of mice

Dinet, V., An, N., Ciccotosto, G. D., Bruban, J., Maoui, A., Bellingham, S. A., Hill, A. F., Andersen, O. M., Nykjaer, A., Jonet, L., Cappai, R. & Mascarelli, F. 1 mar 2011 I : Acta Neuropathologica. 121, 3, s. 351-63 13 s.

Publikation: Forskning - peer reviewTidsskriftartikel

The structure of MESD45-184 brings light into the mechanism of LDLR family folding

Köhler, C., Lighthouse, J. K., Werther, T., Andersen, O. M., Diehl, A., Schmieder, P., Du, J., Holdener, B. C. & Oschkinat, H. 2011 I : Structure. 19, 3, s. 337-48 12 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Identification of a linear epitope in sortilin that partakes in pro-neurotropin binding

Andersen, O. S., Boisguerin, P., Glerup, S., Skeldal, S., Volkmer, R., Wilnow, T. E., Nykjær, A. & Andersen, O. M. 2010 I : Journal of Biological Chemistry. s. 12210-12222 22 s.

Publikation: ForskningTidsskriftartikel

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.

Kjølby, M. F., Andersen, O. M., Breiderhoff, T., Fjorback, A. N., Pedersen, K-M., Madsen, P. S., Jansen, P., Heeren, J., Willnow, T. & Nykjær, A. 2010 I : Cell Metabolism. 12, 3, s. 213-223 11 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Interaction of the Apolipoprotein E Receptors low-density lipoprotein receptor related protein and sorLA/LR11

Spoelgen, R., Adams, K. W., Koker, M., Thomas, A. V., Andersen, O. M., Hallet, P. J., Bercury, K. K., Joyner, D. F., Deng, M., Stoothoff, W. H., Strickland, D. K., Willnow, T. E. & Hyman, B. T. 2009 I : Journal of Neuroscience. 158, s. 1460-1468 8 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: Evidence for a proximal role in Alzheimer's disease

Dodson, S. E., Andersen, O. M., Karmali, V., Fritz, J. J., Cheng, D., Peng, J., Levey, A. I., Wilnow, T. E. & Lah, J. J. 2008 I : The Journal of neuroscience : the official journal of the Society for Neuroscience. 28, s. 12877-12886 9 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependant stimulation of ERK signalling and adult neurogenesis

Rohe, M., Carlo, A. S., Breyhan, H., Sporbert, A., Millitz, D., Schmidt, V., Wozny, C., Harmeier, A., Erdmann, B., Bales, K. R., Wolf, S., Kempermann, G., Paul, S. M., Schmitz, D., Bayer, T. A., Wilnow, T. E. & Andersen, O. M. 2008 I : Journal of Biological Chemistry. J. Biol Chem, 283, s. 14826-14834 8 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII.

Sarafanov, A. G., Makagonenko, E. M., Andersen, O., Mikhailenko, I. A., Ananyeva, N. M., Khrenov, A. V., Shima, M., Strickland, D. K. & Saenko, E. L. 2007 I : Thromb. Haemost.98, s. 1170-1181 12 s.

Publikation: Forskning - peer reviewTidsskriftartikel

SorLA/LR11 regulates processing of the amyloid precursor protein via interactions with adaptors GGA and PACS-1.

Schmidt, V., Sporbert, A., Rohe, M., Reimer, T., Rehm, A., Andersen, O. & Wilnow, T. E. 2007 I : Journal of Biological Chemistry. 282, s. 32956-32964 9 s.

Publikation: Forskning - peer reviewTidsskriftartikel

The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family.

Köhler, C., Andersen, O., Diehl, A., Krause, G., Schmieder, P. & Oschkinat, H. 2007 I : J. Struct. Funct. Genom.7, s. 131-138 8 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Binding site structure of one LRP/RAP complex - Implications for common ligand-receptor binding motif.

Jensen, G. A., Andersen, O., Bonvin, A. M., Bjerrum-Bohr, I., Etzerodt, M., Thøgersen, H. C., O'Shea, B., Poulsen, F. M. & Kragelund, B. B. 2006 I : J. Mol. Biol.362, s. 700-716 17 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein and β-secretase, BACE.

Spoelgen, R., Peltan, I. D., Thomas, A. V., Koker, M., von Armin, C. A. F., Deng, A., Andersen, O., Willnow, T. E. & Hyman, B. T. 2006 I : The Journal of neuroscience : the official journal of the Society for Neuroscience. 45, 8, s. 2618-2628 11 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Molecular Dissection of the Interaction Between Amyloid Precursor Protein and Its Neuronal Trafficking Receptor SorLA/LR11.

Andersen, O., Schmidt, V., Spoelgen, R., Gliemann, J., Behlke, J., Galatis, D., McKinstry, W. J., Parker, M. W., Masters, C. L., Hyman, B. T., Cappai, R. & Wilnow, T. E. 2006 I : Biochemistry. 45, 8, s. 2618-2628 11 s.

Publikation: Forskning - peer reviewTidsskriftartikel

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer's Disease.

Rogaeva, E., Meng, Y., Lee, J. H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C. T., Cheng, R., Hasegawa, H., Chen, F., Shíbata, N., Lunetta, K. L., Pardossi-Piquard, R., Bohm, C., Wakutani, Y., Cupples, L. A., Kuenco, K. T., Green, R. C., Pinessi, L., Rainero, I., Sorbi, S., Bruni, A., Duara, R., Friedland, R., Inzelberg, R., Hampe, W., Bujo, H., Song, Y., Andersen, O., Wilnow, T. E., Graff-Redford, N., Petersen, R. C., Dickson, D., Der, S. D., Fraser, P. E., Ulms, G., Younkin, S., Mayeux, R., Farrer, L. A. & St George-Hyslop, P. 2006 I : Nat. Genet.39, s. 168-177 10 s.

Publikation: Forskning - peer reviewTidsskriftartikel

LRP2/Megalin is required for patterning of the ventral telencephalon.

Spoelgen, R., Hammes, A., Anzenberger, U., Sechner, D., Andersen, O., Jerchow, B. & Wilnov, T. E. 2005 I : Developement. 132, s. 405-414 9 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Andersen, O., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., Arnim, C. A. V., Breiderhoff, T., Jansen, P., Wu, X., Bales, K. R., Cappai, R., Masters, C. L., Gliemann, J., Mufson, E. J., Hyman, B. T., Paul, S. M., Nykjær, A. & Wilnow, T. E. 2005 I : National Academy of Sciences. Proceedings. s. 13461-13466 5 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Ca2+ binding to complement-type repeat domains 5 and 6 from the low density lipoprotein receptor-related protein.

Andersen, O., Vorum, H., Honoré, B. & Thøgersen, H. C. 2003 I : B M C Biochemistry. 4, 1, s. 7-7 1 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Differential binding of ligands to the Apolipoprotein E Receptor 2.

Andersen, O., Benhayon, D., Curran, T. & Willnov, T. E. 2003 I : Biochemistry. 42, s. 9355-9364 9 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Essential Role of the Apolipoprotein E Receptor-2 in Sperm Development.

Andersen, O., Yeung, C. H., Vorum, H., Wellner, M., Andreassen, T. K., Erdmann, B., Mueller, E. C., Herz, J., Otto, A., Cooper, T. G. & Willnov, T. E. 2003 I : Journal of Biological Chemistry. 278, s. 23989-23995 7 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Analysis of a two-domain binding site for the urokinase-type plasminogen activator - plasminogen activator inhibitor-1 complex in low density lipoprotein receptor-related protein,

Andersen, O., Petersen, H. H., Jacobsen, C., Moestrup, S. K., Etzerodt, M., Andreasen, P. & Thøgersen, H. C. 2001 I : Biochem. J.357, s. 289-296 8 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Dominant thermodynamic role of the third independent receptor binding site in the receptor-associated protein RAP.

Andersen, O., Schwarz, F. P., Eisenstein, E., Jacobsen, C., Moestrup, S. K., Etzerodt, M. & Thøgersen, H. C. 2001 I : Biochemistry. 40, s. 15408-15417 10 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Identification of the minimal functional unit in the low density lipoprotein receptor-related protein for binding the receptor-associated protein (RAP)

Christensen, L. L., Christensen, P. A., Sørensen, E. S., Jacobsen, C., Moestrup, S. K., Etzerodt, M., Thøgersen, H. & Andersen, O. 2000 I : Journal of Biological Chemistry. 275, 28, s. 21017-21024 8 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Specific Binding of a-Macroglobulin to Complement-type Repeat CR4 of the Low Density Lipoprotein Receptor-related Protein.

Andersen, O., Christensen, P. A., Christensen, L. L., Jacobsen, C., Moestrup, S. K., Etzerodt, M. & Thøgersen, H. C. 2000 I : Biochemistry. 39, 35, s. 10627-10633 7 s.

Publikation: Forskning - peer reviewTidsskriftartikel

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Institut for Biomedicin
Aarhus Universitet
Victor Albeck Bygningen
Vennelyst Boulevard 4
8000 Aarhus C
Mail: biomed@au.dk

Stedkode: 4211
EAN-nr.: 5798000418486
VAT/CVR-nr: 31119103

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Aarhus Universitet
Nordre Ringgade 1
8000 Aarhus C

E-mail: au@au.dk
Tlf: 8715 0000
Fax: 8715 0201

CVR-nr: 31119103
EAN-numre: www.au.dk/eannumre

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