Ece Kilic

Ph.d.-studerende

Ece Kilic

Profil

PhD project: Vitamin D fortification with enhanced bioavailability

University: Aarhus University

Department: Department of Food Science

Supervisor: Professor Hanne Christine Bertram

Co-supervisors: Associate professor Trine Kastrup Dalsgaard, Postdoc Ulrik Kræmer Sundekilde

Project supervisor: Professor Hanne Christine Bertram

Project term: 01/08/2017 – 31/07/2020

Master’s degree: MSc. in Food Science and Technology, National University of Singapore

 

BACKGROUND

As being a person who believes food is medicine, I would like to investigate holistically how dietary intervention (this can be either by supplementation or elimination of specific foods from diet) affect metabolic syndrome (increased blood pressure, high blood sugar, abnormal cholesterol or triglyceride levels) and inflammatory diseases (allergy, asthma, autoimmune diseases, inflammatory bowel disease etc.) during my research career. Metabolomics is the approach that I will study the changes of metabolites in biofluids (blood, urine, faeces) over time in nutritional intervention studies.

 

AIM

The aim of my PhD is to i) develop and employ metabolomics as a quantitative tool for post prandial studies focused on mapping the broad metabolic response (covering different metabolite classes) and ii) elucidate if vitamin D supplementation influences metabolism that may be related to insulin sensitivity and other parameters related to metabolic health.

 

RESEARCH OUTLINE

The project is based on acute human meal studies complemented with studies in animal models and in vitro studies. The ability of different milk proteins to stabilize and enhance bioavailability of vitamin D will be elucidated by a combination of in vitro digestion studies and an animal study. In acute human meal studies vitamin D supplementation will be investigated in different food matrices to examine the impact of food matrix on vitamin D uptake and absorption, and metabolomics will be carried out on blood and urine samples to understand potential interactions between the postprandial metabolic response and vitamin D metabolism.

 

PARTNERS OF COLLABORATION

The project is part of a larger interdisciplinary research project with participants from AU-FOOD, AU-Health, iNANO-AU, University of Lleida, Arlafoods amba, Arla Food Ingredients, Rynkeby, and DSM.

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