Daniela Grimm


Curriculum Vitae




Professor Daniela Gabriele Grimm, MD

Professorat Space Medicine, Institute of Biomedicine, Pharmacology, Aarhus University, Aarhus, Denmark

Specialist: Clinical Pharmacology and Internal Medicine




Office Addresses:      Institute of Biomedicine/Pharmacology

                                    Aarhus University

                                    Wilhelm Meyers-Allé 4

                                    DK-8000 Aarhus


                                    Tel. +45-87167693

                                    Fax: +45-86128804   


Place of Birth:           Lohr am Main, Bavaria, Germany


Citizenship:                German


Major Research Interests:

  1. 1.     Translational Medicine – Tissue Engineering of artificial vessels and cartilage
  2. 2.     Cardiovascular Pharmacology – Renin-Angiotensin-System, Hypertension
  3. 3.     Angiogenesis – Angiogenesis-Blockade and Cancer
  4. 4.     Cellular Biology  and Space Life Sciences
  • (Tumor Biology): Tumor cells, establishment of thyroid cancer cell lines, characterization, mechanisms of apoptosis
  • Atherosclerosis: Biology of endothelial cells, vascular smooth muscle cells
  • Influence of simulated microgravity on tumor cells and normal cells (fibroblasts, vascular smooth muscle cells, adipocytes, chondrocytes e.c.)
  • Tissue Engineering (multicellular spheroids, tubular structures)
  • Xenograft tumor model of the nude mice


  1. 5.     SPACE RESEARCH

4.1  Parabolic Flight Campaigns

12th DLR Parabolic flight campaign in Bordeaux-Merignac, April 2008: Short-term effects of weightlessness on the transcription behavior of healthy and malignant human cells: Part I http://www.dlr.de/rd/en/desktopdefault.aspx/tabid-4692/7772_read-12040/

13th DLR Parabolic flight campaign in Bordeaux-Merignac, February 2009: Short-term effects of weightlessness on the transcription behavior of healthy and malignant human cells: Part II http://www.dlr.de/rd/desktopdefault.aspx/tabid-5174/8705_read-15615/

14th DLR Parabolic flight campaign in Cologne, September 2009: The effects of nebivolol on endothelial cells during a parabolic flight Part I http://www.dlr.de/rd/desktopdefault.aspx/tabid-5965/9713_read-19388/

16th DLR Parabolic flight campaign in Bordeaux-Merignac, November 2010: The effects of nebivolol on endothelial cells during a parabolic flight Part II http://www.dlr.de/rd/desktopdefault.aspx/tabid-7058/11696_read-27586/

20th DLR Parabolic flight campaign in Bordeaux-Merignac, September 2012: http://www.dlr.de/rd/en/desktopdefault.aspx/tabid-8090/13863_read-35208/admin-1/

4.2 Principal Investigator of Experiment 14 (Thyroid Cancer Cells in Space) of the Shenzhou-8 Flight Mission (PR China), flown in November 2011

4.3 Principal Investigator of the NASA-SPACE X Dragon Cellbox Experiment – Thyroid Cancer Cells in Space, planned start December 9, 2013, Kennedy Space Center, Cape Canaveral, FL, USA.

 4.4 Principal Investigator of the ESA-ISS Mission SPHEROIDS (Endothelial cells in Space), planned start with NASA-SPACE X Dragon, August 8, 2015

4.5 Principal Investigator of the FLUMIAS Texus rocket flight TX52 and TX53 in 2015

4.6 PI of the ESA-CORA-ground based facility projects to investigate the impact of altered gravity on human cells (ESA-CORA-GBF-2010-201; ESA-CORA-GBF-2010-202; ESA-CORA-GBF-2010-203; ESA-CORA-GBF-2011-205; ESA-CORA-GBF-2013-001 and ESA-CORA-GBF-2013-004)


Education:                 1981                       High School diploma, Mozart-Gymnasium Würzburg     

1981 - 1988           Study of Medicine, Faculty of Medicine, University of Würzburg, Germany

1989                      M.D., University of Würzburg, Germany

2004                      Specialist in Internal Medicine

2004                      Habilitation, Venia Legendi in Internal Medicine

2007                      Specialist in Clinical Pharmacology

Faculty Appointments:

1989 – 1992           Residency, Institute of Pathology, University of Regensburg (Director: Prof. Dr. F. Hofstädter)

1992 – 1999          Residency and Internship, Scientific Assistant, Department of Internal Medicine II:  Cardiology, Nephrology and Pneumology, Medical Faculty, University of Regensburg, Germany (Director: Prof. Dr. G.A.J. Riegger)

1999-2011             Head of Research Group: Molecular Pharmacology and Tumor Biology, Institute of Clinical Pharmacology and Toxicology CBF/CCM

Charité-Universitätsmedizin Berlin (Director: Prof. Dr. M. Paul)

12/2004-2010        Senior scientific team leader C2, Pharmacology,

since 8/2008 guest scientist in Berlin        

2008-2011             Associate Professor at the Department of Pharmacology, University of Aarhus, Denmark

 since 01.09.2011    Professor for Space Medicine, Institute of Biomedicine


Peer Review for Scientific Journals:

Cardiovascular Research

Cardiovascular Pathology

Journal of Molecular Medicine

European Heart Journal


Journal of Vascular Research

European Journal of Internal Medicine

Clinical and Experimental Hypertension

Clinical and Experimental Pharmacology and Physiology

Journal of Applied Physiology

Basic & Clinical Pharmacology & Toxicology

Journal of Cellular Physiology

Canadian Journal of Physiology and Pharmacology

Life Sciences

Biochimica et Biophysica Acta

Acta Astronautica

Advances in Space Research

Cell Communication and Signaling

Molecular and Cellular Biochemistry

Tissue Engineering

Cellular Physiology and Biochemistry

Growth Hormone & IGF Research

Analytical and Bioanalytical Chemistry

Plos One

Journal of Cellular Biochemistry

Journal of Proteomics

Journal of Proteome Research

The FASEB Journal


The Open Enzyme Inhibition Journal

Parasitology Research

Nature Cancer Reviews

Experimental Cell Research

Journal of Perinatal Medicine


Awards and honors of my research group:

European Society of Cardiology (October 1996 in Baden-Baden): Isoproterenol-induced heart failure: Effects of ACE-Inhibition, Angiotensin II-Type1 receptor antagonism and Beta-receptor blockade

Young Investigator Awards of my working group:

 European Society of Hypertension, Prag 2002:

Kossmehl P,  Grimm D,  Rothermund L,   Paul M,  Kreutz R. ESH Young Investigator Initiative. Blood Pressure and left ventricular effects of endothelin A receptor blockade in experimental salt-sensitive genetic hypertension.

9th European Symposium on Life Sciences Research in Space and 26th Annual International Gravitational Physiology Meeting, 'Life in Space for Life on Earth' ESA) 26. 06-1. 07. 2005, Köln, Germany. Young Researcher Award 2005:

Kossmehl-Zorn S, Grimm D, Schönberger J, Infanger M, Cogoli A, Paul M, Kossmehl P. 13-cis-retinoic acid alters rate of apoptosis and extracellular matrix proteins in thyroid carcinoma cells under cultured microgravity

German Society for High Blood Pressure Research, 29th Scientific Meeting 2005 in Berlin

Young Investigator Award 2005.

Kossmehl P, Wehland M, Kreutz R, Paul M, Grimm D. Mechanisms of apoptosis in ischemia and reperfusion: Influence of the Renin-Angiotensin-System.


Joint meeting of The German and Dutch Pharmacological Societies, 21-22 June 2007, Eigtved’s Pakhus, Copenhagen, Denmark, Scholarship:

Ulbrich C, Faramarzi S, Westphal K, Infanger M, Paul M, Grimm D. Effects of basic fibroblast growth factor under simulated microgravity

 Hypertension 2007: 31. German Society for High Blood Pressure Research in Bochum 22.11. - 24.11.2007

Young Investigator Award 2007:

Faramarzi S, Ulbrich C, Westphal K, Wehland M, Kreutz R, Paul M, Grimm D. Ein neues Ischämie-Reperfusions-Modell: Untersuchung von VEGF und Rezeptor-Tyrosin-Kinasen.


Symposium "Life in Space for Life on Earth", in Angers 22-27 June,

Young Researcher Award 2008

Pietsch J, Ulbrich C, Westphal K, Winkler HDF, Leder A, Egli M, Bauer J, Grimm D. Simulated microgravity and human chondrocytes


Editorial Board Membership

The Open Enzyme Inhibition Journal: since 2/2008

Since 04.2008 European Science Foundation: ESF peer reviewer


Reviewer for national and international funding-boards:

Reviewer      for ESA International AO-Proposals (Peer review since 2005)

Reviewer for Netherlands Organisation for Scientific Research (NWO, the Dutch research council) for funding since 2006

Reviewer for the Swiss National Science Foundation

Reviewer for the Health Research Board Ireland

Reviewer for Sheikh Hamdan Awards for Medical Sciences ( MRG 5), Dubai, United Arab Emirates in 2012


Computer literacy: MS-Office, SPSS, Internet, WinList, Netscape, Sigma Plot,

Harvard Graphics, Isis Draw and others

Memberships in professional and honorary societies: Scientific advisory boards of state, private or industrial organisations:

  • German      Collection of Microorganisms and Cell Cultures (DSMZ Braunschweig,      Germany) until 2007
·       Scientific advisory board member of Immunolab, DLR – German Space Agency, Bonn ·       ESA Topical Team: Advanced Compound Microscopy (from Molecules to Organism Morphology)


Member of national and international science networks (e. g. coordination of EU-Projects):

  • Center of      Space Medicine Berlin
  • ESA-AO      2004-PCP-006: international Project (Belgium, Switzerland, Italy, France,      Netherlands and Germany); Principal Investigator (PI)
  • ESA-CORA-GBF-2004-003:      Switzerland (ETH Zürich) - Germany (BD Munich and Charité University      Medicine Berlin); PI
  • ESA-CORA-GBF-2010-201:      Aarhus University, Denmark, FFE Weber GmBH Munich and SIHATHO GmbH      Biedenkopf - TUBES Project; PI
  • ESA-CORA-GBF-2010-202:      University, Denmark, ETH Zurich, Switzerland and SIHATHO GmbH Biedenkopf – THYROID Project; PI
  • ESA-CORA-GBF-2010-203: University, Denmark, DLR      Cologne, Germany and SIHATHO GmbH Biedenkopf – VIBRATION Project; PI
  • ESA-CORA-GBF-2011-005:      DLR Cologne, Germany, Aarhus University, Denmark, and SIHATHO GmbH Biedenkopf      –  DEVICE COMPARISON Project; PI
  • ESA-CORA-GBF-2013-001:      DLR Cologne, Germany, Aarhus University, Denmark - THYROID 3; PI
  • ESA-CORA-GBF-2013-004:      Lucerne, Switzerland and Aarhus University, Denmark – CARTILAGE; PI



  1. Founder member of the Center of Space Medicine ,      Berlin - ongoing
  2. Hartmannbund Germany (Association of German      Physicians) until 2008
  3. General Medical Council Berlin, Germany until      2008
  4. PAN international
  5. Deutscher      Hochschulverband (Association of German Universities)
  6. Elected representative member of the faculty      council, faculty of medicine, Free University of Berlin until 2003  
  7. until 2007, elected member of commissions      (science, international connections, and others), member of the review      commission for multiple choice questions, representative for pharmacology,      Charité-Universitätsmedizin Berlin
  8. Since 2012 Member of the Space Life Sciences      PhD School Cologne, Germany – Tissue Engineering http://www.dlr.de/me/desktopdefault.aspx/tabid-7891/

 Venia Legendi; Habilitation in Internal Medicine: 28. October 2004

Molecular and structural aspects of the extracellular matrix in cardiovascular diseases

Aarhus, July 1, 2013

Daniela Gabriele Grimm