Arne Møller

Pathological gambling: Relation of skin conductance response to dopaminergic neurotransmission and sensation-seeking.

Publikation: ForskningTidsskriftartikel

  • PET-Centret, forskningsafdeling
  • Center for Funktionelt Integrativ Neurovidenskab
Absent Skin Conductance Response (SCR) in pathological gambling (PG) may relate to dopaminergic
mechanisms. We recruited equal numbers of PG subjects and healthy control (HC) subjects, and
then tested the claim that SCR is less conditioned by dopaminergic activity in PG subjects. During
active gambling, SCR differed in PG and HC subjects (Pb0.05), but positron emission tomography
revealed the same dopamine receptor availability. However, highly sensation-seeking (HS) PG
subjects had lower dopamine receptor availability (Pb0.0001) in the baseline, compared to normal
sensation-seeking (NS) PG subjects. We find that HS versus NS controls had the same observation of
significant increase of binding potential (BPND) in high compared to normal sensation seekers. In
both groups, PG and HC, highly sensation-seeking subjects had significant increase of receptor
availability in striatum, compared to normally sensation-seeking subjects, separately (Pb0.05 and
P=0.02, respectively) and together (Pb0.0005). We conclude that SCR is less conditioned by
dopaminergic activity in highly sensation-seeking subjects, regardless of PG status.
OriginalsprogEngelsk
TidsskriftEuropean Neuropsychopharmacology
Vol/bind20
Sider (fra-til)766–775
Antal sider10
ISSN0924-977X
StatusUdgivet - 2010

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